Expandable tissue thickness compensator

• US 9,301,753 B2
• Filed: 03/28/2012
• Issued: 04/05/2016
• Est. Priority Date: 09/30/2010
• Status: Active Grant

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: Ethicon Endo-Surgery LLC (Johnson & Johnson)
• Inventors: Aldridge, Jeffrey L., Yang, Chunlin, Scheib, Charles J., Widenhouse, Christopher W., Weisenburgh, William B. II, Stammen, John L., Ransick, Mark H., Mutchler, Stephanie A., Knight, Gary W.
• Primary Examiner(s): Lopez, Michelle
• Application Number:
  US13/433,098
• Publication Number:
  US 20120241491A1
• Time in Patent Office: 1,469 Days
• Field of Search: 227/175.1, 227/176.1, 606/151
• US Class Current: 1/1
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/0643 with separate closing member, e.g. for interlocking with staple
• CPC Class Codes: A61B 17/0644 penetrating the tissue, deformable to closed position
• CPC Class Codes: A61B 17/068 Surgical staplers , e.g. containing multiple staples or clampsstaplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105; for performing anastomosis A61B17/115; staplers in general B25C5/00
• CPC Class Codes: A61B 17/0682 for applying U-shaped staples or clamps, e.g. without a forming anvil
• CPC Class Codes: A61B 17/072 for applying a row of staples in a single action , e.g. the staples being applied simultaneously
• CPC Class Codes: A61B 17/07207 the staples being applied sequentially
• CPC Class Codes: A61B 17/07292 Reinforcements for staple line, e.g. pledgets
• CPC Class Codes: A61B 17/105 Wound clamp magazines for packaging sharps A61B50/3001
• CPC Class Codes: A61B 17/1155 Circular staplers comprising a plurality of staples
• CPC Class Codes: A61B 17/2909 Handles
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/00314 Separate linked members
• CPC Class Codes: A61B 2017/00327 with actuating members moving in opposite directions
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/0053 Loading magazines or sutures into applying tools
• CPC Class Codes: A61B 2017/00561 creating a vacuum
• CPC Class Codes: A61B 2017/00818 Treatment of the gastro-intestinal system
• CPC Class Codes: A61B 2017/00862 elastic or resilient for sutures A61B2017/0618
• CPC Class Codes: A61B 2017/00884 enhancing wound closure
• CPC Class Codes: A61B 2017/00889 : antimicrobial, disinfectant
• CPC Class Codes: A61B 2017/00893 : pharmaceutically effective
• CPC Class Codes: A61B 2017/00898 : expandable upon contact with fluid
• CPC Class Codes: A61B 2017/00938 : hydrophobic
• CPC Class Codes: A61B 2017/00942 : hydrophilic
• CPC Class Codes: A61B 2017/0641 : having at least three legs as part of one single body
• CPC Class Codes: A61B 2017/07228 : Arrangement of the staples
• CPC Class Codes: A61B 2017/07235 : containing different staples, e.g. staples of different shapes, sizes or materials
• CPC Class Codes: A61B 2017/07242 : achieving different staple heights during the same shot, e.g. using an anvil anvil having different heights or staples of different sizes
• CPC Class Codes: A61B 2017/07264 : characterised by its staple forming cavities, e.g. geometry or material
• CPC Class Codes: A61B 2017/07271 : characterised by its cartridge
• CPC Class Codes: A61B 2017/07278 : characterised by its sled or its staple holder
• CPC Class Codes: A61B 2017/07285 : characterised by its cutter
• CPC Class Codes: A61B 2017/2908 : Multiple segments connected by articulations
• CPC Class Codes: A61B 2017/2919 : details of linkages or pivot points
• CPC Class Codes: A61B 2017/2923 : Toothed members, e.g. rack and pinion
• CPC Class Codes: A61B 2017/2927 : the angular position of the head being adjustable with respect to the shaft
• CPC Class Codes: A61B 2017/2933 : camming or guiding means
• CPC Class Codes: A61B 2017/2936 : Pins in guiding slots
• CPC Class Codes: A61B 2017/2937 : with flexible part
• CPC Class Codes: A61B 2017/320052 : Guides for cutting instruments by marking A61B2090/395
• CPC Class Codes: A61B 2090/0807 : Indication means

Abstract

A tissue thickness compensator may generally comprise a biocompatible material, a first component, and a second component, wherein the first component and second component form a reaction product to expand the tissue thickness compensator. The first component may comprise a first hydrogel precursor, the second component may comprise a second hydrogel precursor, and the reaction product may comprise a hydrogel. The reaction product may be formed in vivo and/or in situ by contacting the first component and the second component. The first component and/or second component may be encapsulated and configured to release the components when ruptured. The reaction product may comprise a fluid-swellable composition. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.

Claims

1. An article selected from an anvil of a stapling apparatus and a staple cartridge for a stapling apparatus, the article comprising:

a tissue thickness compensator comprising;

an outer layer comprising polyglycolic acid, polylactic acid, polydioxanone, polyhydroxyalkanoate, poliglecaprone, polycaprolactone, and combinations thereof; and

an inner layer comprising oxidized regenerated cellulose, a first encapsulated component comprising a first hydrogel precursor, and a second encapsulated component comprising a second hydrogel precursor;

wherein the first hydrogel precursor and second hydrogel precursor form a hydrogel to expand the tissue thickness compensator when the first encapsulated component and second encapsulated component are ruptured.

2. An article selected from an anvil of a stapling apparatus and a staple cartridge for a stapling apparatus, the article comprising:

a tissue thickness compensator comprising;

a biocompatible material;

a first component; and

a second component;

wherein the first component and second component form a reaction product to expand the tissue thickness compensator, and wherein the first component comprises a hydrophilic material embedded in the biocompatible material and the second component is a bodily fluid.

3. An article selected from an anvil of a stapling apparatus and a staple cartridge for a stapling apparatus, the article comprising:

a tissue thickness compensator comprising;

a biocompatible material;

a first component; and

a second component;

wherein the first component and second component form a reaction product to expand the tissue thickness compensator, wherein the tissue thickness compensator comprises a first encapsulated component comprising the first component and a second encapsulated component comprising the second component, and wherein the first encapsulated component is configured to release the first component when the first encapsulated component is ruptured, and the second encapsulated component is configured to release the second component when the second encapsulated component is ruptured.

4. An article selected from an anvil of a stapling apparatus and a staple cartridge for a stapling apparatus, the article comprising:

a tissue thickness compensator comprising;

a biocompatible material;

a first component; and

a second component;

wherein the first component and second component form a reaction product to expand the tissue thickness compensator, and wherein the reaction product is formed in situ by contacting the first component and the second component.

5. An article selected from an anvil of a stapling apparatus and a staple cartridge for a stapling apparatus, the article comprising:

a tissue thickness compensator comprising;

a biocompatible material;

a first component; and

a second component;

wherein the first component and second component form a reaction product to expand the tissue thickness compensator, and wherein the first component comprises a first hydrogel precursor, the second component comprises a second hydrogel precursor, and the reaction product comprises a hydrogel.