Ocular disorder treatment implants with multiple opening

• US 9,301,875 B2
• Filed: 03/18/2005
• Issued: 04/05/2016
• Est. Priority Date: 04/08/2002
• Status: Active Grant

• Current Assignee: Glaukos Corporation
• Original Assignee: Glaukos Corporation
• Inventors: Tu, Hosheng, Artof, Jason, Haffner, David Steven, Smedley, Gregory T., Niksch, Barbara A.
• Primary Examiner(s): Tyson, Melanie
• Application Number:
  US11/084,314
• Publication Number:
  US 20050271704A1
• Time in Patent Office: 4,036 Days
• Field of Search: 604/8, 604/9, 604/27, 604/264, 604/268, 606/108, 606/107, 623/4.1
• US Class Current: 1/1
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61M 27/006 Cerebrospinal drainage; Accessories therefor, e.g. valves

Abstract

Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm'"'"'s canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm'"'"'s canal as well as preventing the walls of Schlemm'"'"'s canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.

Claims

1. An implant for treating an ocular disorder, the implant comprising:

an inlet portion configured to be positioned in an anterior chamber of an eye;

an outlet portion in fluid communication with the inlet portion, the outlet portion configured to be positioned at least partially in Schlemm'"'"'s canal of the eye;

an intermediate portion disposed between the inlet and outlet portions, the intermediate portion having a longitudinal axis passing therethrough;

wherein the outlet portion comprises a bulbous portion having at least two patent outlet openings along a surface of said bulbous portion, said outlet openings being in fluid communication with said outlet and inlet portions;

wherein a transverse dimension of said bulbous portion increases from a distal end of said bulbous portion towards a proximal end of said bulbous portion;

wherein the proximal end of the bulbous portion comprises a substantially flat surface extending from the intermediate portion and lying substantially perpendicularly to the longitudinal axis of the intermediate portion; and

wherein the two outlet openings are disposed so as to direct fluid flow in opposite directions of Schlemm'"'"'s canal.

2. The implant of claim 1, wherein said surface is curvilinear.

3. The implant of claim 1, wherein said surface is polyhedral.

4. The implant of claim 1, wherein said bulbous portion has a shape that comprises at least part of a sphere.

5. The implant of claim 1, wherein said bulbous portion has a shape that comprises at least part of an ellipsoid.

6. The implant of claim 1, wherein said bulbous portion is substantially hemispherical in shape.

7. The implant of claim 1, wherein at least a portion of the implant comprises a conical configuration.

8. The implant of claim 1, wherein said bulbous portion comprises a conical or frusto-conical configuration.

9. The implant of claim 1, wherein a long axis of the inlet portion defines a flow path for fluid flowing from the anterior chamber and said substantially flat surface is arranged substantially symmetrically about said long axis.

10. The implant of claim 1, wherein a long axis of the inlet portion defines a flow path for fluid flowing from the anterior chamber and said substantially flat surface generally circumscribes said long axis.

11. The implant of claim 1, wherein a long axis of the inlet portion defines a flow path for fluid flowing from the anterior chamber and an outer-most periphery of said substantially flat surface is substantially equidistantly spaced from said long axis.

12. The implant of claim 1, wherein a long axis of the inlet portion defines a flow path for fluid flowing from the anterior chamber and said surface of said bulbous portion generally circumscribes said long axis.

13. The implant of claim 12, wherein said surface of said bulbous portion comprises a tapered surface between said proximal and distal ends, and wherein respective outlet orifices of said outlet openings are skewed relative to said long axis.

14. The implant of claim 1, wherein at least one of said patent outlet openings is generally circular in shape.

15. The implant of claim 1, wherein at least one of said patent outlet openings has a longitudinal dimension and a transverse dimension that are comparable in size.

16. The implant of claim 1, wherein said implant is shaped substantially in the form of a mushroom with said inlet portion comprising a portion of a stem of the mushroom and said bulbous portion comprising at least a portion of a head of the mushroom.

17. The implant of claim 1, wherein said implant further comprises an anchor extending distally relative to said outlet portion.

18. An implant for treating an ocular disorder, the implant comprising:

an inlet portion configured to be positioned in an anterior chamber of an eye;

an outlet portion in fluid communication with the inlet portion, the outlet portion configured to be positioned at least partially in a physiologic outflow pathway of the eye; and

an intermediate portion disposed between the inlet and outlet portions, the intermediate portion having a longitudinal axis passing therethrough;

wherein the outlet portion comprises a bulbous portion having at least two patent outlet openings along a surface of said bulbous portion, said outlet openings being in fluid communication with said outlet and inlet portions;

wherein a transverse dimension of said bulbous portion increases from a distal end of said bulbous portion towards a proximal end of said bulbous portion;

wherein the proximal end of the bulbous portion comprises a substantially flat surface extending from the intermediate portion and lying substantially perpendicularly to the longitudinal axis of the intermediate portion; and

wherein the two outlet openings are disposed so as to direct fluid flow in opposite directions of Schlemm'"'"'s canal.

19. The implant of claim 18, wherein the bulbous portion has a shape that comprises at least part of an ellipsoid.

20. The implant of claim 18, wherein the bulbous portion comprises a conical or frusto-conical configuration.

21. The implant of claim 18, wherein the substantially flat surface is arranged substantially symmetrically around the longitudinal axis.

22. The implant of claim 18, wherein at least one of said patent outlet openings is generally circular in shape.

23. The implant of claim 18, wherein at least one of said patent outlet openings has a longitudinal dimension and a transverse dimension that are comparable in size.