Natural combination hormone replacement formulations and therapies
DCFirst Claim
1. A pharmaceutical formulation for administering estradiol and progesterone to a mammal in need thereof, comprisingsolubilized estradiol,solubilized progesterone,suspended progesterone, andan oil,wherein each of the solubilized estradiol, the solubilized progesterone, and the suspended progesterone is present in the oil, andwherein the oil comprises medium chain fatty acid esters of glycerol, polyethylene glycol, or propylene glycol, or mixtures thereof, wherein the medium chain fatty acid esters are predominantly esters of C6 to C12 fatty acids.
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Abstract
Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
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Citations
14 Claims
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1. A pharmaceutical formulation for administering estradiol and progesterone to a mammal in need thereof, comprising
solubilized estradiol, solubilized progesterone, suspended progesterone, and an oil, wherein each of the solubilized estradiol, the solubilized progesterone, and the suspended progesterone is present in the oil, and wherein the oil comprises medium chain fatty acid esters of glycerol, polyethylene glycol, or propylene glycol, or mixtures thereof, wherein the medium chain fatty acid esters are predominantly esters of C6 to C12 fatty acids.
Specification