Microneedle devices and production thereof
First Claim
1. A device for transport of molecules or energy across or into a biological barrier, comprising:
- a plurality of microneedles, wherein each microneedle formed of a first molding material, wherein the first molding material comprises a mixture of a) a polymer first material and b) a second material comprising rigid particles dispersed therein, wherein the first molding material is micromolded into the plurality of microneedles.
3 Assignments
0 Petitions
Accused Products
Abstract
Microneedle devices and methods of manufacture are provided for transport of molecules or energy across or into biological barriers, such as skin. The device can comprise one or more microneedles formed of a first material and a second material, wherein the second material is dispersed throughout the first material or forms a portion of the microneedle. The first material preferably is a polymer. The second material can be pore forming agents, structural components, biosensor, or molecules for release, such as drug. The device also can comprise a substrate and a plurality of microneedles extending from the substrate, wherein the microneedles have a beveled or tapered tip portion, a longitudinally extending exterior channel, or both. Methods of making these devices include providing a mold having a plurality of microdepressions which define the surface of a microneedle; filling the microdepressions with a first molding material; and molding the material, thereby forming microneedles.
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Citations
36 Claims
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1. A device for transport of molecules or energy across or into a biological barrier, comprising:
a plurality of microneedles, wherein each microneedle formed of a first molding material, wherein the first molding material comprises a mixture of a) a polymer first material and b) a second material comprising rigid particles dispersed therein, wherein the first molding material is micromolded into the plurality of microneedles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A device for transport of molecules or energy across or into a biological barrier, comprising;
a plurality of microneedles, each microneedle formed of a polymer first material and a second material, wherein the second material comprises rigid particles that are dispersed throughout at least a portion of the polymer and wherein the first material and second material are disposed in a layered relationship with respect to each other, and wherein the first material and second material are disposed in an alternating horizontal layer configuration with respect to each other. - View Dependent Claims (21, 22, 23, 24, 25, 26)
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27. A device for transport of molecules or energy across or into a biological barrier comprising;
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a plurality of microneedles, each microneedle formed of a first molding material, wherein the first molding material comprises a mixture of a) a polymer first material and b) a second material, comprising rigid particles dispersed therein; and a substrate from which the plurality of microneedles extend. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36)
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Specification