UNA duplex oligomers for therapeutics
First Claim
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1. An oligomer comprising one or more 2′
- -3′
-seco-nucleomonomers and one or more natural or non-natural nucleotide monomers, wherein the oligomer is a duplex having first and second strands, and wherein the 2′
-3′
-seco-nucleomonomers are monomer D
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Abstract
This invention provides UNA oligomers for therapeutics that can be used to modulate or reduce gene expression. The UNA oligomers can be composed of one or more 2′-3′-seco-nucleomonomers and one or more natural or non-natural nucleotide monomers, and can be a duplex having first and second strands. Embodiments include UNA oligomers with phosphorothioate or boranophosphate intermonomer linkages. The UNA oligomers can provide reduced off target effects while modulating gene expression.
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Citations
20 Claims
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1. An oligomer comprising one or more 2′
- -3′
-seco-nucleomonomers and one or more natural or non-natural nucleotide monomers, wherein the oligomer is a duplex having first and second strands, and wherein the 2′
-3′
-seco-nucleomonomers are monomer D - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- -3′
Specification