Aptamers that bind CD271

• US 9,303,263 B2
• Filed: 02/28/2014
• Issued: 04/05/2016
• Est. Priority Date: 03/01/2013
• Status: Active Grant

• Current Assignee: Vivonics Inc.
• Original Assignee: Vivonics Inc.
• Inventors: Gilman, Vladimir Leo
• Primary Examiner(s): McGarry, Sean
• Application Number:
  US14/382,681
• Publication Number:
  US 20150376619A1
• Time in Patent Office: 767 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 31/711 Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• CPC Class Codes: A61L 2300/258 Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2430/00 Materials or treatment for tissue regeneration
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C12N 15/115 Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
• CPC Class Codes: C12N 2310/16 Aptamers
• CPC Class Codes: C12N 2320/30 Special therapeutic applications

Abstract

The invention generally relates to aptamers that bind CD271. In certain aspects, the invention provides an isolated nucleic acid ligand that binds to CD271, in which the nucleic acid ligand includes the nucleotide sequence of SEQ ID NO: 1 or the nucleotide sequence of SEQ ID NO: 2.

Claims

1. An implantable medical product, the product comprising:

a scaffold composed of a biocompatible material; and

a plurality of nucleic acid ligands that binds to CD271, wherein the nucleic acid ligands comprise the nucleotide sequence of SEQ ID NO;

1 or the nucleotide sequence of SEQ ID NO;

2.

2. The product according to claim 1, wherein the scaffold is porous.

3. The product according to claim 2, wherein the ligands are coupled to an external surface of the scaffold.

4. The product according to claim 2, wherein the ligands are coupled to an internal surface of the scaffold.

5. The product according to claim 2, wherein the ligands are coupled to both an external surface and an internal surface of the scaffold.

6. The product according to claim 1, wherein the scaffold is bioresorbable.