Multimodal automated sensory testing system

• US 9,307,906 B2
• Filed: 10/01/2010
• Issued: 04/12/2016
• Est. Priority Date: 10/02/2009
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Harte, Steven E., Kruger, Grant H., Clauw, Daniel
• Primary Examiner(s): Dvorak, Linda
• Assistant Examiner(s): LLOYD, EMILY M
• Application Number:
  US12/896,331
• Publication Number:
  US 20110082384A1
• Time in Patent Office: 2,020 Days
• Field of Search: 600/553, 600/557
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0053 by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
• CPC Class Codes: A61B 5/4824 Touch or pain perception evaluation A61B5/4821 takes precedence
• CPC Class Codes: A61B 5/4827 assessing touch sensitivity, e.g. for evaluation of pain threshold

Abstract

A computer-controlled sensory testing system is disclosed that can be used to further pain research and aid in the clinical diagnosis and treatment of pain syndromes. The system includes actuators to deliver pressure/deformation (strain), auditory, olfactory, and other stimuli to a subject. The system includes software to control the delivery of the stimuli. The system is further operable to receive feedback regarding the stimuli received.

Claims

1. A stimulator system for sensory testing of a subject by stimulating a portion of the subject and receiving feedback from the subject, comprising:

a housing member having;

a stimulation site having a surface within the housing member, the surface configured to be accessible through an aperture in the housing member, wherein the aperture is configured to allow the portion of the subject to access a passage in the housing member to position the portion of the subject on the surface;

a transducer member associated with a drive system, wherein the transducer member is moveable by the drive system at least towards the surface of the stimulation site through a drive aperture in the housing member, wherein the transducer member is positioned to at least apply pressure on at least the portion of the subject and bias the portion of the subject against the surface of the stimulation site;

a power source coupled to the drive system;

a controller operably coupled to the drive system;

a communication system coupled to the controller; and

an input system for sending at least a user input signal including the feedback from the subject to the controller of a rating by the subject regarding at least the pressure applied on at least the portion of the subject by the transducer member.

2. The stimulator system of claim 1, further comprising:

a display located on the housing member or remote from the housing member.

3. The stimulator system of claim 1, further comprising:

a central processor operable to communicate with the controller on the housing member;

wherein the central processor is operable to send a pressure stimulation signal via the communication system to automatically apply pressure to the portion of the subject according to a pre-determined procedure and the central processor is configured to receive subject feedback based on the automatically applied pressure.

4. The stimulator system of claim 3, further comprising:

a memory system configured to store software incorporating the pre-determined procedure which includes at least one of rate and duration of application of force, peak force, incremental or continuous force application, inter-stimulus interval, or patient response scales.

5. The stimulator system of claim 3, further comprising:

in addition to the transducer member, at least one of an auditory stimulator, an appendage stimulator, a chew stimulator, an olfactory stimulator, and a visual stimulator;

wherein the least one of the auditory stimulator, the appendage stimulator, the chew stimulator, the olfactory stimulator, and the visual stimulator is operable to receive a further stimulation signal from the central processor to stimulate the subject in addition to or alternatively to the transducer member.

6. The stimulator system of claim 1, wherein the drive system comprises:

an electric motor configured to be powered by the power source housed within the housing member; and

a rack and pinion assembly configured to convert rotational movement of the electric motor to linear movement;

wherein the transducer member is associated with the rack and pinion assembly.

7. The stimulator system of claim 1, wherein the communication system is configured to at least one of send or receive signals wirelessly.

8. The stimulator system of claim 1,

wherein the stimulation site is configured to be accessible through the aperture and passage in the housing member by the portion of the subject when grasped by a hand of the subject.

9. A method of operating a sensory stimulation system and receiving a feedback from a subject regarding sensory stimulation, comprising:

accessing and executing a stored program by at least one processor to transmit a stimulation signal to a stimulator system to apply a stimulus including a pressure to the subject based on instructions of the stored program;

initiating operation of the stimulator system;

operating the stimulator system, after the initiation of the stimulator system, automatically and based on the executed program and the stimulation signal transmitted to the stimulator system to apply a stimulus to the subject;

receiving the feedback from the subject regarding the applied stimulus including pressure based on operation of the stimulator system regarding the applied stimulus, wherein the feedback from the subject includes a rating regarding the applied stimulus including pressure;

receiving a feedback from the stimulator system regarding the applied stimulus;

analyzing at least one of (i) the received feedback from the subject regarding the applied stimulus including pressure or (ii) the received feedback from the stimulator system;

placing at least one digit of a hand of the subject on a digit placement site within a housing member; and

applying the stimulus including the pressure to the at least one digit of the subject, including;

moving a transducer member with a drive system, at least towards the digit placement site through a drive aperture in the housing member, wherein the transducer member is positioned to apply the pressure on at least a portion of the at least one digit and biasing the at least one digit against the digit placement site;

receiving the stimulation signal with a receiver of the stimulator system from the at least one processor based on the executed instructions; and

operating the drive system with a drive system controller based on the received stimulation signal.

10. The method of claim 9, further comprising:

providing a wireless communication system coupled to the stimulator system receiver to allow the stimulator system receiver to be configured to wirelessly receive the stimulation signal; and

executing instructions with the drive system controller based on the received stimulation signal to move the transducer member according to the stimulation signal.

11. The method of claim 10, further comprising:

inputting the feedback from the subject in response to the movement of the transducer member including the rating regarding the applied pressure.

12. The method of claim 11, wherein inputting the feedback from the subject includes inputting the time of the onset of pain.

13. The method of claim 10, further comprising:

sensing a force that is applied to the at least one digit with the transducer member;

sensing a strain resulting from deformation at a stimulation site; and

sending at least one of (i) a force signal based on the sensed force to the at least one processor or (ii) a strain signal based on the sensed strain to the at least one processor;

wherein applying the stimulus includes biasing the at least one digit against the digit placement site further includes biasing the at least one digit against a surface within the housing member.

14. The method of claim 13, further comprising:

providing at least a first processor of the at least one processor in the housing member; and

providing a user input system located on a surface of the housing member for inputting the feedback from the subject.

15. The method of claim 13, further comprising:

wherein sensing the strain is used for a feedback control of at least one of a force, a position, and a speed of the transducer member of the stimulator system;

wherein the drive system controller is configured to incorporate linearized calibration curves to ensure accurate and repeatable application of the stimulus to the subject based at least on the stimulation signal.

16. The method of claim 9, further comprising:

driving the transducer member with the drive system; and

applying the stimulus with driving the transducer member to the at least one digit;

wherein the stimulus is applied automatically according to the executed program.

17. The method of claim 9,

wherein applying the stimulus to the subject with the stimulator system further includes at least one of an auditory stimulus, a visual stimulus, and an olfactory stimulus.

18. The method of claim 9, further comprising:

monitoring strain at a stimulation location as a result of applying the stimulus that includes a pressure stimulus to the stimulation location of the subject;

wherein receiving feedback from the stimulator system regarding the applied stimulus includes monitoring an applied stress and monitoring the strain;

wherein receiving feedback from the subject based on operation of the stimulator system regarding the applied stimulus includes receiving a perceived stimulus response from the subject including a rating over time indicating at least an increasing or a decreasing pain; and

analyzing the received feedback from the stimulator system and the received feedback from the subject by executing instructions with the provided at least one processor to provide a report based on a test including applying the stimulus.

19. The method of claim 18, wherein initiating operation of the stimulator system includes using an on button located on a hand piece of the stimulator system;

wherein operating the stimulator system commences at least one preconfigured testing algorithm;

wherein receiving feedback from the subject is entering directly with the hand piece via a control panel or one or more buttons located directly on the hand piece without additional input devices.

20. The method of claim 18, wherein initiating operation of the stimulator system is performed by the subject;

wherein operating the stimulator system further includes a custom configured testing algorithm and an in real-time monitor testing progress or analyzing results in real-time.

21. The method of claim 9, wherein the rating regarding the applied pressure includes at least one of a time of an onset of pain, a rating over time of increasing or decreasing pain, or combinations thereof.

22. The method of claim 9, wherein analyzing the at least one received feedback includes displaying a value of the at least one feedback or a diagnosis based on the at least one received feedback.

23. A pressure stimulator system for sensory testing at least a digit of a human user and a feedback system from the human user, comprising:

a housing member configured to be held in a single hand of the human user while the digit is placed against a digit placement surface, wherein the housing member has an aperture through an exterior wall of the housing member configured to allow access to the digit placement surface by the digit of the single hand within the housing member;

a drive system operable to be powered with a power source, wherein both the drive system and the power source are within the housing member;

a transducer member coupled to the drive system, wherein the transducer member is moveable by the drive system at least towards the digit placement surface through a drive aperture in an internal wall of the housing member, wherein the transducer member is configured to apply pressure on at least a portion of the digit of the human user and bias the digit against the digit placement surface to apply a pressure to the digit with the transducer member;

a local controller to control the drive system; and

an input system for inputting a human user signal from the human user to relate a perception of the human user based on the applied pressure on at least the portion of the digit of the human user.

24. The pressure stimulator system of claim 23, further comprising:

a central processor and a central processor wireless communication system; and

a local controller wireless communication system;

wherein the central processor is configured to send or receive a signal from the local controller with the central processor wireless communication system and the local controller wireless communication system.

25. The pressure stimulator system of claim 24, further comprising:

a sensor to sense the amount of pressure or deformation applied to the digit;

wherein the signal is a stimulation signal regarding the sensed amount of pressure or deformation.

26. The pressure stimulator system of claim 25, wherein the drive system includes an electric motor and the power source is a battery;

wherein the electric motor drives a rack and pinion assembly that is configured to drive the transducer member.

27. The pressure stimulator system of claim 24, wherein the signal includes at least a first signal and a second signal;

wherein the first signal is a test procedure signal communicating a test procedure to the local controller for operating the drive system; and

wherein the second signal is the human user input signal, wherein the second signal is operable to indicate at least one of an onset of pain in the human user or a rating of a pain over a time;

wherein at least one of the central processor or the local controller is configured to execute instructions to analyze a relationship of the test procedure signal and the human user input signal based on an applied stimulus with the transducer member.