Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
First Claim
1. A composition suitable for use against an infectious pathogen comprising:
- an immunogenic amount of an infectious pathogen or biological toxin antigen preparation of interest; and
an adjuvant of heterologous extracellular matrix, wherein the immunogenic amount of the infectious pathogen or biological toxin antigen preparation of interest in the presence of the adjuvant is less than the immunogenic amount of the infectious pathogen or biological toxin antigen preparation of interest that elicits a detectable protective response in the absence of the adjuvant, wherein the infectious pathogen antigen preparation of interest comprises an inactivated preparation of the infectious pathogen antigen of interest or toxic products thereof.
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Accused Products
Abstract
Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.
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Citations
16 Claims
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1. A composition suitable for use against an infectious pathogen comprising:
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an immunogenic amount of an infectious pathogen or biological toxin antigen preparation of interest; and an adjuvant of heterologous extracellular matrix, wherein the immunogenic amount of the infectious pathogen or biological toxin antigen preparation of interest in the presence of the adjuvant is less than the immunogenic amount of the infectious pathogen or biological toxin antigen preparation of interest that elicits a detectable protective response in the absence of the adjuvant, wherein the infectious pathogen antigen preparation of interest comprises an inactivated preparation of the infectious pathogen antigen of interest or toxic products thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification