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Protein formulation

  • US 9,308,257 B2
  • Filed: 11/26/2008
  • Issued: 04/12/2016
  • Est. Priority Date: 11/28/2007
  • Status: Active Grant
First Claim
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1. A liquid pharmaceutical formulation comprising between about 25 μ

  • g/ml and about 250 μ

    g/ml of a single chain bispecific antibody comprising a first and a second binding domain, wherein the first binding domain specifically binds CD3 T cell surface antigen; and

    wherein the formulation comprises between about 5 mM and about 125 mM citrate, between about 100 mM and about 300 mM lysine, between about 10% and about 20% trehalose, and between about 0.01% and about 1% Polysorbate 80, and has a pH of between 5.0 and about 8.0.

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