Pharmaceutical composition for administration to nails
First Claim
1. A method for the treatment of a disease or condition affecting a nail, comprising administering to the nail a topical pharmaceutical composition comprisingan effective amount of an active ingredient which is (i) an immunosuppressant selected from the group consisting of tacrolimus, sirolimus, everolimus, pimecrolimus, ridaforolimus, temsirolimus, zotarolimus, and ciclosporin A, or (ii) an antifungal agent selected from the group consisting of clotrimazole, ketoconazole, miconazole, terbinafine, naftifine, butenafine, ciclopiroxolamine and amorolfine, anda semifluorinated alkane according to formula
RFRH
or
RFRHRFwherein:
- RF is a perfluorinated hydrocarbon segment with 20 or less carbon atoms, and RH is a non-fluorinated hydrocarbon segment with 3 to 20 carbon atoms.
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Accused Products
Abstract
The invention provides semi-solid or liquid pharmaceutical compositions for topical administration to a finger- or toenail of a human. The compositions are useful for the delivery of active ingredients deep into the nail. Various active ingredients may be incorporated, such as antifungal agents, anti-infectives, anti-inflammatory agents, immunosuppressants, local anesthetics, and retinoids.
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Citations
13 Claims
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1. A method for the treatment of a disease or condition affecting a nail, comprising administering to the nail a topical pharmaceutical composition comprising
an effective amount of an active ingredient which is (i) an immunosuppressant selected from the group consisting of tacrolimus, sirolimus, everolimus, pimecrolimus, ridaforolimus, temsirolimus, zotarolimus, and ciclosporin A, or (ii) an antifungal agent selected from the group consisting of clotrimazole, ketoconazole, miconazole, terbinafine, naftifine, butenafine, ciclopiroxolamine and amorolfine, and a semifluorinated alkane according to formula
RFRH
or
RFRHRFwherein: - RF is a perfluorinated hydrocarbon segment with 20 or less carbon atoms, and RH is a non-fluorinated hydrocarbon segment with 3 to 20 carbon atoms.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
Specification