Polymer derivatives comprising an acetal or ketal branching point

• US 9,308,273 B2
• Filed: 10/03/2013
• Issued: 04/12/2016
• Est. Priority Date: 05/03/2004
• Status: Active Grant

• Current Assignee: Nektar Therapeutics
• Original Assignee: Nektar Therapeutics
• Inventors: McManus, Samuel P., Kozlowski, Antoni
• Primary Examiner(s): Tran, Susan
• Assistant Examiner(s): CRAIGO, WILLIAM A
• Application Number:
  US14/045,489
• Publication Number:
  US 20140039167A1
• Time in Patent Office: 922 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: C08G 65/322 containing hydrogen
• CPC Class Codes: C08G 65/329 with organic compounds
• CPC Class Codes: C08G 65/331 containing oxygen cyclic ether compounds C08G65/26
• CPC Class Codes: C08G 65/33306 acyclic
• CPC Class Codes: C08G 65/33337 cyclic
• CPC Class Codes: C08G 65/3348 containing nitrogen in addition to sulfur
• CPC Class Codes: C08L 2203/02 for biomedical use

Abstract

The invention conjugates that can be prepared by contacting a polymer comprising an acetal or ketal branching point with a pharmacologically active agent under conditions suitable to form a covalent attachment between the polymer and the pharmacologically active agent.

Claims

1. A conjugate prepared by a polymer with a pharmacologically active agent under conditions suitable to form a covalent attachment between the polymer and the pharmacologically active agent, wherein the polymer is selected from the group consisting of

2. The conjugate of claim 1, wherein the pharmacologically active agent is selected from the group consisting of peptides, polypeptides and proteins.