Methods of performing dialysis using an electrodeionization system

• US 9,308,308 B2
• Filed: 10/03/2014
• Issued: 04/12/2016
• Est. Priority Date: 03/06/2009
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc., Millipore Corporation (Merck & Co., Inc.)
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc., Millipore Corporation (Merck & Co., Inc.)
• Inventors: Ding, Yuanpang Samuel, Lo, Ying-Cheng, Miller, Joshua James, Rohde, Justin, Karoor, Sujatha, Dupont, Stephane
• Primary Examiner(s): Kim, John
• Application Number:
  US14/506,018
• Publication Number:
  US 20150021268A1
• Time in Patent Office: 557 Days
• US Class Current: 1/1
• CPC Class Codes: A61M 1/1674 using UV radiation sources for sterilising the dialysate
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 2202/0014 removed from the body
• CPC Class Codes: B01D 61/243 Dialysis
• CPC Class Codes: B01D 61/44 Ion-selective electrodialysis
• CPC Class Codes: B01D 61/58 Multistep processes

Abstract

Systems and methods for hemodialysis or peritoneal dialysis having integrated electrodeionization capabilities are provided. In an embodiment, the dialysis system includes a carbon source, a urease source and an electrodeionization unit. The carbon source and urease source can be in the form of removable cartridges.

Claims

1. A method of performing peritoneal dialysis comprising:

passing a spent dialysis fluid from an individual through a dialyzer, a carbon source, a urease source and an electrodeionization unit to produce a clean dialysis fluid, the dialyzer comprising an ion-rejection membrane selected from the group consisting of a first ion-rejection membrane that allows the passage of negatively charged ions and non-ionic species but restricts the passage of positively charged ions, and a second ion-rejection membrane that allows the passage of positively charged ions and non-ionic species but restricts the passage of negatively charged ions; and

returning the clean dialysis fluid to the individual.

2. The method of claim 1, which includes passing the clean dialysis fluid through an ion exchange unit before the clean dialysis fluid returns to the patient.

3. The method of claim 1, which includes adding at least one dialysis component to the clean dialysis fluid before the clean dialysis fluid returns to the individual.

4. The method of claim 1, which includes passing the clean dialysis fluid through a filter before the clean dialysis fluid returns to the patient.

5. The method of claim 1, which includes passing the clean dialysis fluid through an ultraviolet bactericidal light before the clean dialysis fluid returns to the patient.

6. A method of performing dialysis comprising:

passing a spent dialysis fluid through a dialysis compartment of a dialyzer comprising an ion-rejection membrane that allows the passage of negatively charged ions and non-ionic species but restricts the passage of positively charged ions, the ion-rejection membrane separating the dialysis compartment from a dialysate compartment of the dialyzer;

passing used dialysis fluid generated from the dialysate compartment of the dialyzer through a carbon source, a urease source and an electrodeionization unit to produce a clean dialysis fluid;

adding a source of negative ions to the clean dialysis fluid; and

passing the clean dialysis fluid through the dialysate compartment of the dialyzer.

7. A method of performing dialysis comprising:

passing a spent dialysis fluid through a dialysis compartment of a dialyzer comprising an ion-rejection membrane that allows the passage of positively charged ions and non-ionic species but restricts the passage of negatively charged ions, the ion-rejection membrane separating the dialysis compartment from a dialysate compartment of the dialyzer;

passing used dialysis fluid generated from the dialysate compartment of the dialyzer through a carbon source, a urease source and an electrodeionization unit to produce a clean dialysis fluid;

adding a source of positive ions to the clean dialysis fluid; and

passing the clean dialysis fluid through the dialysate compartment of the dialyzer.