System and method for determining target stimulation volumes

• US 9,310,985 B2
• Filed: 03/27/2012
• Issued: 04/12/2016
• Est. Priority Date: 05/15/2008
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Blum, David Arthur, Kokones, Scott, Moffitt, Michael A., Barnhorst, Jordan, Carlton, Keith
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): PHAM, MINH DUC GIA
• Application Number:
  US13/431,258
• Publication Number:
  US 20120330374A1
• Time in Patent Office: 1,477 Days
• Field of Search: 607/45
• US Class Current: 1/1
• CPC Class Codes: A61B 34/25 User interfaces for surgical systems
• CPC Class Codes: A61N 1/36128 Control systems
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means
• CPC Class Codes: F04C 2270/041 Controlled or regulated
• CPC Class Codes: G06F 18/22 Matching criteria, e.g. proximity measures
• CPC Class Codes: G06F 3/04815 Interaction with a metaphor-based environment or interaction object displayed as three-dimensional, e.g. changing the user viewpoint with respect to the environment or object
• CPC Class Codes: G06F 3/04845 for image manipulation, e.g. dragging, rotation, expansion or change of colour
• CPC Class Codes: G06T 11/003 Reconstruction from projections, e.g. tomography
• CPC Class Codes: G06T 11/60 Editing figures and text; Combining figures or text
• CPC Class Codes: G06T 15/005 General purpose rendering architectures
• CPC Class Codes: G06T 15/08 Volume rendering
• CPC Class Codes: G06T 19/00 Manipulating 3D models or images for computer graphics
• CPC Class Codes: G06T 19/003 Navigation within 3D models or images
• CPC Class Codes: G06T 2200/04 involving 3D image data
• CPC Class Codes: G06T 2200/24 involving graphical user interfaces [GUIs]
• CPC Class Codes: G06T 2207/10064 Fluorescence image
• CPC Class Codes: G06T 2207/10072 Tomographic images
• CPC Class Codes: G06T 2207/10081 Computed x-ray tomography [CT]
• CPC Class Codes: G06T 2207/10088 Magnetic resonance imaging [MRI]
• CPC Class Codes: G06T 2207/10092 Diffusion tensor magnetic resonance imaging [DTI]
• CPC Class Codes: G06T 2207/30016 : Brain
• CPC Class Codes: G06T 2219/028 : Multiple view windows (top-side-front-sagittal-orthogonal)
• CPC Class Codes: G06T 3/40 : Scaling of whole images or parts thereof, e.g. expanding or contracting
• CPC Class Codes: G06T 3/4038 : Image mosaicing, e.g. composing plane images from plane sub-images
• CPC Class Codes: G06T 7/0012 : Biomedical image inspection
• CPC Class Codes: G06T 7/30 : Determination of transform parameters for the alignment of images, i.e. image registration
• CPC Class Codes: G06T 7/33 : using feature-based methods
• CPC Class Codes: G06T 7/38 : Registration of image sequences
• CPC Class Codes: G16H 20/40 : relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• CPC Class Codes: G16H 30/20 : for handling medical images, e.g. DICOM, HL7 or PACS
• CPC Class Codes: G16H 30/40 : for processing medical images, e.g. editing

Abstract

A system and method may include determining a target stimulation volume based on modifying a patient population image for which an efficacious volume had been determined. A system and method for suggesting stimulation devices may include determining which stimulation device is capable of producing an output volume of activation that most closely matches the target volume. A system and method for facilitating selection of stimulation parameters may include graphically identifying a maximum volume in which tissue is stimulatable by an implanted stimulation device. A system and method may pre-compute volumes of activation that result from a predetermined modification of programming settings. A system and method may transmit stimulation programming settings from a stimulation programming module to a stimulation generating device.

Claims

1. A computer-implemented method for determining a stimulation volume for a subject patient, the method comprising:

associating, by a computer processor, anatomical features in a first image, corresponding to an anatomical region of the subject patient, with corresponding anatomical features in a second image, corresponding to an anatomical region of at least one selected patient from a patient population, wherein a stimulation volume has been predetermined for the at least one selected patient; and

warping, by the processor, a combination of the second image and the stimulation volume predetermined for the at least one selected patient so that the anatomical features in the second image of the combination match the anatomical features in the first image, the warped combination thereby providing for the subject patient one of a target stimulation volume, defined by an outline of a region targeted to be activated by a stimulation, and a side effect stimulation volume, defined by an outline of a region, activation of which by a stimulation is estimated to cause a side effect.

2. The method of claim 1, wherein the at least one selected patient is selected based on at least one clinical similarity with the subject patient.

3. The method of claim 2, wherein the at least one similarity includes a similarity between at least a portion of the first image and at least a corresponding portion of the second image.

4. The method of claim 1, wherein the second image is a composite image of anatomical regions of a plurality of selected patients from the patient population.

5. The method of claim 4, wherein the anatomical region of the at least one selected patient is a composite anatomical region corresponding to the plurality of selected patients.

6. The method of claim 1, further comprising:

repeating the steps of warping to thereby provide the target stimulation volume responsive to a detected modification of the predetermined stimulation volume.

7. The method of claim 6, wherein the predetermined stimulation volume is modified in response to a recorded behavioral response of the at least one selected patient resulting from a stimulation treatment.

8. A computer-implemented method for determining a stimulation volume for a subject patient, the method comprising:

associating, by a computer processor, anatomical features in a first image, corresponding to an anatomical region of the subject patient, with corresponding anatomical features in a second image, corresponding to an anatomical region of at least one selected patient from a patient population, wherein a stimulation volume has been predetermined for the at least one selected patient;

modifying, by the processor, the second image so that spatial relationships of the anatomical features in the second image match spatial relationships of the anatomical features in the first image;

modifying a spatial relationship of the stimulation volume to the second image based on the modification to the second image to generate a new spatial relationship; and

determining for the subject patient one of a target stimulation volume, defined by an outline of a region targeted to be activated by a stimulation, and a side effect stimulation volume, defined by an outline of a region, activation of which by a stimulation is estimated to cause a side effect, by applying the new spatial relationship to the modified second image.