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Method and system for automating sample preparation for microfluidic cryo TEM

  • US 9,312,095 B2
  • Filed: 03/24/2011
  • Issued: 04/12/2016
  • Est. Priority Date: 03/24/2010
  • Status: Active Grant
First Claim
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1. A method of preparing a cryogenic transmission electron microscopy sample grid, comprising:

  • providing a sample carrier grid having nanoscale sample openings;

    forming a fluid droplet at the end of a first capillary;

    bringing said droplet into contact with a top surface of said carrier grid thereby depositing said droplet onto said top surface; and

    bringing a second capillary onto contact with said droplet to withdraw a portion of the fluid from said droplet to form a microfluidic sample on said top surface,wherein said steps of forming a fluid droplet, bringing the droplet into contact with a top surface and bringing a second capillary into contact with the droplet are controlled using a computer.

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