Analyte signal processing device and methods

• US 9,314,195 B2
• Filed: 08/31/2010
• Issued: 04/19/2016
• Est. Priority Date: 08/31/2009
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Fennell, Martin J.
• Primary Examiner(s): Lau, Tung S
• Application Number:
  US12/873,294
• Publication Number:
  US 20110060530A1
• Time in Patent Office: 2,058 Days
• Field of Search: 702/19
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0209 adapted for power saving
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/7228 Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal modulation H03C
• CPC Class Codes: G01N 15/01 specially adapted for biological cells, e.g. blood cells investigating sedimentation of particle suspensions in blood G01N15/05
• CPC Class Codes: G01N 15/0606 by collecting particles on a support
• CPC Class Codes: G01N 15/0656 using electric, e.g. electrostatic methods or magnetic methods by investigating individual particles G01N15/1031, G01N15/12

Abstract

Methods, devices, and systems are provided that include an analyte sensor interface electronics for receiving a plurality of analyte related signals from an analyte sensor over a measurement time period, and a data processing component operatively coupled to the analyte sensor interface electronics for processing the received plurality of analyte related signals, the data processing component including a signal filtering component to filter the received plurality of analyte related signals, and a signal conversion component operatively coupled to the signal filtering component to convert the received filtered plurality of analyte related signals to determine an analyte level associated with a monitored analyte level during the measurement time period.

Claims

1. A signal processing device used for processing analyte related signals, comprising:

analyte sensor interface electronics for receiving a plurality of analyte related signals from an analyte sensor over a measurement time period; and

a data processing component operatively coupled to the analyte sensor interface electronics for processing the received plurality of analyte related signals, the data processing component including;

a signal filtering component to filter the received plurality of analyte related signals; and

a signal conversion component operatively coupled to the signal filtering component to convert the received filtered plurality of analyte related signals to determine an analyte level associated with a monitored analyte level during the measurement time period;

wherein the signal conversion component includes a clock to generate a plurality of clock signals; and

further

wherein the signal conversion component synchronizes each of the received filtered plurality of analyte related signals to a corresponding one of the generated plurality of clock signals to generate a frequency data stream based on the received filtered plurality of analyte related signals, where the frequency data stream is accumulated over the measurement time period to filter out one or more signal artifacts, the measurement time period establishing a maximum signal resolution as a function of analog to digital conversion time to obtain a higher signal resolution.

2. The device of claim 1, wherein at least a portion of the one or more analyte sensor interface electronics or the data processing components includes an application specific integrated circuit.

3. The device of claim 1, wherein each pulse in the frequency data stream is associated with a respective one of the generated plurality of clock signals.

4. The device of claim 1, wherein the signal conversion component includes a sigma delta modulation unit.

5. The device of claim 1, including a communication component to transmit data associated with the determined analyte level over a communication connection.

6. The device of claim 1, wherein the analyte sensor includes a glucose sensor.

7. The device of claim 1, wherein the analyte sensor comprises a plurality of electrodes including a working electrode comprising an analyte-responsive enzyme bonded to a polymer disposed on the working electrode.

8. The device of claim 1, wherein the analyte sensor comprises a plurality of electrodes including a working electrode comprising a mediator bonded to a polymer disposed on the working electrode.

9. The device of claim 1, wherein the received filtered plurality of analyte related signals are analog voltage signals.

10. The device of claim 1, wherein the accumulated frequency data stream is averaged over the measurement time period.

11. The device of claim 5, wherein the communication component includes an RF transmitter.

12. The device of claim 5, wherein the communication connection includes one or more of a wired communication link or a wireless communication link.

13. The device of claim 6, wherein the glucose sensor includes at least one working electrode in signal communication with the analyte sensor interface electronics.

14. The device of claim 7, wherein the analyte-responsive enzyme is chemically bonded to the polymer.

15. The device of claim 7, wherein the working electrode further comprises a mediator.

16. The device of claim 8, wherein the mediator is chemically bonded to the polymer.

17. The device of claim 13, wherein the working electrode of the sensor comprises one of carbon or gold.

18. The device of claim 15, wherein the mediator is crosslinked with the polymer.