Closure device with rapidly eroding anchor

• US 9,314,230 B2
• Filed: 08/22/2014
• Issued: 04/19/2016
• Est. Priority Date: 01/09/2009
• Status: Active Grant

• Current Assignee: Abbott Vascular Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Vascular Incorporated (Abbott Laboratories Incorporated)
• Inventors: Roorda, Wouter E., Voss, Laveille K., McCrystle, Kelly J., Osman, Karim S.
• Primary Examiner(s): Templeton, Christopher L
• Application Number:
  US14/466,576
• Publication Number:
  US 20140364903A1
• Time in Patent Office: 606 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/0061 Implements located only on one side of the opening
• CPC Class Codes: A61B 2017/00623 Introducing or retrieving devices therefor
• CPC Class Codes: A61B 2017/00637 for sealing trocar wounds through abdominal wall
• CPC Class Codes: A61B 2017/00654 entirely comprised between the two sides of the opening
• CPC Class Codes: A61B 2017/00659 located only on one side of the opening
• CPC Class Codes: A61B 2017/00663 the implement being a suture
• CPC Class Codes: A61B 2017/00668 the implement being a tack or a staple
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

An anchor for use with a closure device includes a body being configured to move from a pre-deployed state to a deployed state. In the pre-deployed state, the body has a first width aspect relative to a direction of deployment and a second width aspect in the deployed state relative to the direction of deployment, the second width aspect being greater than the first width aspect and the body being formed from a rapidly eroding material configured to erode through dissolution within a body lumen.

Claims

1. A closure device for sealing an intravascular puncture site located in a wall in a blood vessel, the blood vessel defining a body lumen having a blood stream, the closure device comprising:

a closure element made of biocompatible, hemostatic material;

an anchor; and

a tether extending through the anchor and the closure element,

wherein the anchor comprises a body being configured to move from a pre-deployed state to a deployed state, wherein in the pre-deployed state the body has a first width aspect relative to a direction of deployment, and a second width aspect in the deployed state relative to the direction of deployment, the second width aspect being greater than the first width aspect,

wherein the body is formed from a rapidly eroding material configured to erode through dissolution within a body lumen, the rapidly eroding material being a solid solution based on a sugar alcohol solvent and a solute,

wherein the anchor initially has sufficient structural integrity to deploy through the puncture site and function as an anchor during placement of the closure element, and

wherein the anchor erodes or dissolves more rapidly than the closure element so that, once the anchor is placed in the body lumen, it rapidly erodes or dissolves in the blood stream and leaves behind the closure element.

2. The closure device of claim 1, wherein the body is configured to erode in less than twelve hours.

3. The closure device of claim 1, wherein the body is configured to erode in less than one hour.

4. The closure device of claim 1, wherein the body includes a major axis and wherein the body is configured to rotate in response to a force applied parallel to the major axis.

5. The closure device of claim 1, wherein the sugar alcohol includes mannitol, sorbitol, or isomalt.

6. The closure device of claim 1, wherein the body further includes at least one polymeric component.

7. The closure device of claim 6, wherein the at least one polymeric component includes at least one of poly-vinylpyrrolidone, poly-ethyleneglycol, hydroxyethyl starch, polysaccharide, dextran or dextran sulfate.

8. The closure device of claim 1, wherein the rapidly eroding material includes a plurality of pores.

9. The closure device of claim 8, wherein at least one of the plurality of pores includes at least one beneficial agent.

10. The closure device of claim 1, wherein the anchor includes at least one of poly-vinyl pyrrolidone, hyaluronic acid, dextran, hydrogel, heparin, and benzalkonium heparin.

11. The closure device of claim 1, wherein the anchor is formed using a freeze-drying process.

12. The closure device of claim 1, wherein the solid solution is a solid solution of hydroxyethyl starch in mannitol-sorbitol.

13. The closure device of claim 1, wherein the body includes an eyelet extending through the body.