Ingestible salt grabber

• US 9,314,523 B2
• Filed: 09/21/2010
• Issued: 04/19/2016
• Est. Priority Date: 09/21/2010
• Status: Active Grant

• Current Assignee: Elwha LLC (Intellectual Ventures LLC)
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Kindsvogel, Wayne R., McKnight, Gary L., Wood, Lowell L. Jr.
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): YOUNG, MICAH PAUL
• Application Number:
  US12/924,212
• Publication Number:
  US 20120070380A1
• Time in Patent Office: 2,037 Days
• Field of Search: 424464-489, 604/890.1
• US Class Current: 1/1
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00

Abstract

Disclosed herein include embodiments related to compositions, devices, computer systems, computer-implemented methods, and computer program products associated with an ingestible salt grabber.

Claims

1. A composition, comprising:

a housing with at least one electronic identification device;

the housing containing at least one ingestible ion exchange resin, and one or more thermoswitchable membrane controllable ports with supraparamagnetic iron oxide nanoparticles embedded therein and configured to heat upon exposure of an alternating magnetic field.

2. The composition of claim 1, wherein the at least one housing further includes at least one coating.

3. The composition of claim 2, wherein the at least one housing includes at least one of a permeable coating, or a semi-permeable coating.

4. The composition of claim 3, wherein the at least one housing is semi-permeable for one or more ions.

5. The composition of claim 4, wherein the one or more ions include at least one of sodium, potassium, ammonium, magnesium, iron, lithium, or calcium.

6. The composition of claim 4, wherein the at least one housing is semi-permeable for sodium.

7. The composition of claim 3, wherein the at least one housing is semi-permeable based at least in part on size exclusion.

8. The composition of claim 3, wherein the at least one housing is semi-permeable for one or more locations of a gastro-intestinal tract.

9. The composition of claim 3, wherein the one or more controllable ports are configured to be regulated by at least one of pH, ion level, temperature, light, magnetic field, electrical field, or chemical concentration.

10. The composition of claim 2, wherein the housing is biodegradable and configured to degrade or increase in permeability based at least in part on one or more of external command, schedule, location, or response to one or more sensors.

11. The composition of claim 2, wherein the housing includes at least one of a carbohydrate, protein, or lipid.

12. The composition of claim 2, wherein the housing includes a starch.

13. The composition of claim 2, wherein the housing includes at least one polymer.

14. The composition of claim 1, wherein the resin is configured to selectively bind at least one of sodium, potassium, ammonium, magnesium, iron, lithium, calcium, or phosphates thereof.

15. The composition of claim 1, wherein the porosity of the at least one ingestible resin includes pores of about 0 to about 500 Angstroms in diameter or any value therebetween.

16. The composition of claim 1, wherein the affinity of the at last one ingestible resin for a particular ion is configured to change depending on the location in the gastro-intestinal tract.

17. The composition of claim 1, wherein the affinity of the at least one ingestible resin for a particular ion is configured to change depending on at least one of pH, ion level, temperature, light, or chemical concentration.

18. The composition of claim 1, wherein the affinity of the at least one ingestible resin for a particular ion is configured to change depending on the type of other ions present.

19. The composition of claim 1, wherein the one or more controllable ports are configured to be controlled to at least one of open, close, or modulate permeability of the at least one housing.

20. The composition of claim 1, wherein the one or more controllable ports are configured to be controlled based in part on at least one of external command, schedule, location, or response to one or more sensors.

21. The composition of claim 20, wherein the one or more sensors are configured to detect at least one of pH, ion level, temperature, light, or chemical concentration.

22. The composition of claim 1, wherein the composition includes at least one surface molecule configured to adhere to at least one location of a gastro-intestinal tract.

23. The composition of claim 1, wherein the composition is formulated to be ingested just prior to, during, or just subsequent to food intake.

24. The composition of claim 1, wherein the composition is formulated to be ingested by a subject.

25. The composition of claim 1, wherein the ion exchange resin includes an anion exchange resin.

26. The composition of claim 1, wherein the ion exchange resin includes a cation exchange resin.

27. The composition of claim 1, wherein the at least one ion exchange resin includes at least two ion exchange resins.

28. The composition of claim 27, wherein the at least one ion exchange resin includes at least one of each an anion exchange resin and a cation exchange resin.

29. The composition of claim 1, wherein the housing includes at least a portion of a microchip or nanochip.

30. The composition of claim 1, wherein the at least one ingestible resin is in the form of at least one of bead, powder, or fiber.

31. The composition of claim 1, further including at least one pharmaceutical vehicle or excipient.

32. The composition of claim 1, wherein the at least one ingestible resin includes at least one silicate.

33. The composition of claim 32, wherein the at least one ingestible resin includes zeolite.

34. The composition of claim 1, wherein the housing is at least one of biodegradable, biocompatible, or non-toxic.

35. The composition of claim 1, wherein the one or more controllable ports include at least one hydrogel.

36. The composition of claim 35, wherein the hydrogel includes at least one ferrogel.

37. The composition of claim 1, wherein the housing has controllable permeability.

38. The composition of claim 1, wherein the housing includes one or more coatings.

39. The composition of claim 38, wherein at least one of the coatings has higher permeability for a target ion than a competing ion.

40. The composition of claim 1, wherein the housing includes an enclosure containing the at least one ingestible resin.