Electro-osmotic pumps, systems, methods, and compositions

• US 9,314,567 B2
• Filed: 03/09/2011
• Issued: 04/19/2016
• Est. Priority Date: 03/09/2010
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Shin, Woonsup, Heller, Adam, Nagarale, Rajaram
• Primary Examiner(s): Dieterle, Jennifer
• Application Number:
  US13/583,583
• Publication Number:
  US 20130041353A1
• Time in Patent Office: 1,868 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: F04B 19/006 Micropumps F04B43/043 and F04B43/095 take precedence
• CPC Class Codes: Y10T 29/49236 Fluid pump or compressor making

Abstract

The present disclosure relates, according to some embodiments, to compositions, methods, devices, and systems for delivering a composition (e.g., a fluid composition) to a subject. For example, the present disclosure relates to non-gassing, direct current (DC), electro-osmotic pumps in some embodiments. A pump may comprise an anode (e.g., a porous silver/silver oxide anode), a cathode (e.g., a porous silver/silver oxide cathode), and a membrane (e.g., a porous ceramic membrane) positioned at least partially between the anode and the cathode in some embodiments. A pump system may comprise an electro-osmotic pump, a reservoir comprising a pump fluid chamber in fluid communication with the electro-osmotic pump and a delivery fluid chamber in fluid communication with the electro-osmotic pump; a controller assembly in electrical communication with the anode and the cathode; and a cannula and/or a needle in fluid communication with the delivery fluid chamber. A pump fluid may comprise water and/or a delivery fluid may comprise a drug, in some embodiments.

Claims

1. A direct current electro-osmotic pump comprising:

a porous, platinum-free, carbon-based cathode;

a porous, platinum-free carbon anode; and

a porous ceramic membrane between the cathode and the anode having a first surface and a second surface opposite the first surface,

wherein the porous ceramic membrane comprises vitreous ceramic spheres from about 0.1 μ

m to about 10 μ

m in diameter selected from the group consisting of uncoated silica spheres, spheres comprising oxides of silicon and phosphorus, spheres comprising oxides of silicon and boron, and combinations thereof,

wherein at least a part of the first surface of the membrane is in physical contact with the anode,

and at least a part of the second surface is in physical contact with the cathode, and

wherein the pump is configured to operate at a potential difference (V) between the anode and the cathode of V≦

3 volts without producing bubbles visible to a naked eye.

2. A direct current electro-osmotic pump according to claim 1, wherein

the potential difference (V) between the anode and the cathode is 0.1 volts<

V≦

3 volts at about 25°

C.; and

the electro-osmotic pump is configured to operate with a flow rate per cm² of liquid-contacted area of at least 10 μ

L min<sup>−

1</sup> cm<sup>−

2</sup>.

3. A direct current electro-osmotic pump according to claim 2, wherein the potential difference (V) between the anode and the cathode is 0.1 volts<

V≦

2 volts at about 25°

C.

4. A direct current electro-osmotic pump according to claim 2, wherein the electro-osmotic pump is configured to coulometrically monitor a volume of a pumped solution.

5. A direct current electro-osmotic pump according to claim 1, wherein the porous ceramic membrane is from about 0.1 mm to about 3 mm thick and/or from about 1 mm to about 30 mm wide.

6. A direct current electro-osmotic pump according to claim 1, wherein the anode further comprises an electrically conducting polymer, the cathode further comprises the electrically conducting polymer, or both the anode and cathode further comprise the electrically conducting polymer.

7. A direct current electro-osmotic pump according to claim 6, wherein the electrically conducting polymer is selected from polyaniline and substituted polyaniline.

8. A direct current electro-osmotic pump according to claim 1, wherein the porous anode further comprises an anodic reactant and a cathodic reactant, the porous cathode further comprises the anodic reactant and the cathodic reactant, or both the porous anode and the porous cathode further comprises the anodic reactant and the cathodic reactant.

9. A direct current electro-osmotic pump according to claim 1, wherein the porous ceramic membrane has an outside diameter of 8 mm.