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Apparatus for thermal cycling

  • US 9,316,586 B2
  • Filed: 03/09/2012
  • Issued: 04/19/2016
  • Est. Priority Date: 05/17/2006
  • Status: Active Grant
First Claim
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1. A thermal cycler apparatus comprising:

  • a heat sink;

    a heating component in thermal contact with the heat sink, the heating component having a top surface;

    a closed bather sealing in a liquid composition, the closed bather having a top surface and a bottom surface, the top surface of the closed barrier having a plurality of wells configured to receive a plurality of sample vessels, wherein the wells extend into the liquid composition, and the bottom surface of the closed barrier being positioned in between the top surface of the closed barrier and the top surface of the heating component, the bottom surface of the closed barrier being in thermal contact with the top surface of the heating component; and

    a control assembly in communication with the heating component, the control assembly configured to cycle the temperature of samples in the plurality of sample vessels for nucleic acid amplification.

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