Simple sugar concentration sensor and method

• US 9,320,463 B2
• Filed: 08/10/2015
• Issued: 04/26/2016
• Est. Priority Date: 10/16/2012
• Status: Active Grant

• Current Assignee: K Sciences Gp, LLC
• Original Assignee: K Sciences Gp, LLC
• Inventors: Korman, Valentin
• Primary Examiner(s): Punnoose, Roy M
• Application Number:
  US14/822,524
• Publication Number:
  US 20150342507A1
• Time in Patent Office: 260 Days
• Field of Search: 356/39, 356/364
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0443 Modular apparatus
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/6815 Ear
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 2201/062 LED's
• CPC Class Codes: G01N 2201/0683 Brewster plate; polarisation controlling elements

Abstract

A glucose sensor comprising an optical energy source having an emitter with an emission pattern; a first polarizer intersecting the emission pattern; a second polarizer spaced a distance from the first polarizer and intersecting the emission pattern, the second polarizer rotated relative to the first polarizer by a first rotational amount Θ; a first optical detector intersecting the emission pattern; a second optical detector positioned proximal to the second polarizer, the first polarizer and the second polarizer being positioned between the optical energy source and the second optical detector, the second optical detector intersecting the emission pattern; a compensating circuit coupled to the second optical detector; and a subtractor circuit coupled to the compensating circuit and the first optical detector.

Claims

1. A noninvasive apparatus for measuring glucose, the apparatus comprising:

a housing having at least a first region and a second region, the first region and the second region separated by a space;

an energy source emitting an optical signal, the energy source positioned in the first region of the housing;

a first optical polarizing unit for polarizing at least a portion of the optical signal to provide a first polarized energy, the first optical polarizing unit positioned in the first region of the housing;

a second optical polarizing unit for polarizing at least a portion of the first polarized energy to provide a second polarized energy, the second optical polarizing unit positioned in the second region of the housing;

a first optical detection unit for detecting at least some of the first polarized energy, the first optical detection unit positioned in the second region of the housing, the first optical detection unit having an output;

a second optical detection unit for detecting at least some of the second polarized energy, the second optical detection unit positioned in the second region of the housing, the second optical detection unit having an output; and

a circuit interfaced with and receiving the outputs of the first and second optical detection units, the circuit determining a glucose concentration.

2. The noninvasive apparatus of claim 1, wherein the circuit comprises a compensator for boosting at least a portion of output from the second optical detection unit.

3. The noninvasive apparatus of claim 1, wherein the circuit comprises a subtractor for reducing at least a portion of output from the first optical detection unit.

4. The noninvasive apparatus of claim 1, wherein the optical signal is in a near infrared frequency range.

5. The noninvasive apparatus of claim 1, wherein the second optical polarizing unit is rotated with respect to the first optical polarizing unit, the rotation being a multiple of about 45 degrees.

6. The noninvasive apparatus of claim 1, wherein the second optical polarizing unit is rotated with respect to the first optical polarizing unit, the rotation being any rotation degree between and including 35 and 55 degrees.

7. The noninvasive apparatus of claim 1, wherein the second optical polarizing unit is rotated with respect to the first optical polarizing unit, the rotation being any rotation degree between and including forty and fifty degrees.

8. The noninvasive apparatus of claim 1, wherein any of the first and second optical polarizing units is a polarizing film.

9. The noninvasive apparatus of claim 1, wherein any of the first and second optical polarizing units is a polarizing wire grid.

10. The noninvasive apparatus of claim 1, wherein any of the first and second optical polarizing units is a holographic wire grid.

11. The noninvasive apparatus of claim 1, wherein the first optical polarizing unit is between the energy source and the first optical detection unit.

12. The noninvasive apparatus of claim 1, wherein the second optical polarizing unit is between the energy source and the second optical detection unit.

13. The noninvasive apparatus of claim 1, wherein the second optical polarizing unit is spaced a distance from the first optical polarizing unit, and is proximal to said second optical detection unit.

14. The noninvasive apparatus of claim 1, wherein at least a portion of the first optical polarizing unit is between the energy source and the second optical polarizing unit.

15. The noninvasive apparatus of claim 1, wherein a difference in output from the first optical detection unit and output from the second optical detection provides a value for measuring glucose from fluid contained in the space.

16. The noninvasive apparatus of claim 1, wherein the optical signal is unmodulated.

17. The noninvasive apparatus of claim 1, wherein the energy source is an LED.