Non-invasive systems, devices, and methods for selective brain cooling
First Claim
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1. A method for cooling the brain, comprising:
- directing a non-nebulized free flowing fluid through a plurality of catheters into the aerodigestive tract of a patient such that at least a portion of the free flowing fluid is in direct contact with tissue of the aerodigestive tract and where the free flowing fluid cools blood flowing between the aortic arch and the brain;
actively removing the free flowing fluid from the aerodigestive tract of the patient through at least one of the plurality of catheters; and
recirculating at least a portion of the free flowing fluid through a heat exchanger and the aerodigestive tract where the volume of free flowing fluid directed to the aerodigestive tract is substantially equal to the volume of free flowing fluid that is actively removed from the aerodigestive tract through the plurality of catheters until reaching a brain to body core temperature gradient of at least 3°
C.
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Abstract
Methods, systems, and devices are disclosed for providing selective and non-selective cooling and warming of a patient. Multiple embodiments of devices are disclosed for performing rapid induction and maintenance of therapeutic hypothermia either in a hospital setting or in the field so that hypothermic treatment can be quickly instituted before significant tissue damage occurs. Methods are also disclosed for targeting brain cooling by irrigating the upper airway, aerodigestive tract, and/or more generalized cooling by irrigating the esophagus and/or stomach.
219 Citations
35 Claims
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1. A method for cooling the brain, comprising:
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directing a non-nebulized free flowing fluid through a plurality of catheters into the aerodigestive tract of a patient such that at least a portion of the free flowing fluid is in direct contact with tissue of the aerodigestive tract and where the free flowing fluid cools blood flowing between the aortic arch and the brain; actively removing the free flowing fluid from the aerodigestive tract of the patient through at least one of the plurality of catheters; and recirculating at least a portion of the free flowing fluid through a heat exchanger and the aerodigestive tract where the volume of free flowing fluid directed to the aerodigestive tract is substantially equal to the volume of free flowing fluid that is actively removed from the aerodigestive tract through the plurality of catheters until reaching a brain to body core temperature gradient of at least 3°
C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for cooling the spinal column, comprising:
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directing a non-nebulized free flowing fluid through a plurality of catheters into the aerodigestive tract of a patient such that at least a portion of the free flowing fluid is in direct contact with tissue of the aerodigestive tract and where the free flowing fluid cools blood flowing between the aortic arch and the brain; actively removing the free flowing fluid from the aerodigestive tract of the patient; and recirculating at least a portion of the free flowing fluid through a heat exchanger and the aerodigestive tract where the volume of free flowing fluid that is directed to the aerodigestive tract is substantially equal to the volume of free flowing fluid that is actively removed from the aerodigestive tract until reaching a spinal column to body core temperature gradient of at least 3°
C.
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21. An apparatus for cooling the brain, the apparatus comprising:
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a first catheter configured to direct a non-nebulized free flowing fluid into an aerodigestive tract of a patient where at least a portion the free flowing fluid is in direct contact with tissue of the aerodigestive tract and where the free flowing fluid cools blood flowing between the aortic arch and the brain; a second catheter configured to remove the free flowing fluid from the aerodigestive tract of the patient; and a recirculation system configured to actively recirculate at least a portion of the free flowing fluid through a heat exchanger and the aerodigestive tract where the volume of free flowing fluid that is directed to the aerodigestive tract is substantially equal to the volume of free flowing fluid that is actively removed from the aerodigestive tract until reaching a brain to body core temperature gradient of at least 3°
C. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification