Oral care composition

• US 9,320,699 B2
• Filed: 03/31/2010
• Issued: 04/26/2016
• Est. Priority Date: 03/31/2010
• Status: Active Grant

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Porter, Venda, Morgan, Andre, Prencipe, Michael, Mello, Sarita
• Primary Examiner(s): Duffy, Patricia A
• Assistant Examiner(s): Gotfredson, Garen
• Application Number:
  US13/636,290
• Publication Number:
  US 20130017238A1
• Time in Patent Office: 2,218 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 2800/624 by macromolecular compounds
• CPC Class Codes: A61K 2800/651 The particulate/core comprising inorganic material
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/21 Fluorides; Derivatives thereof
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Disclosed are oral care compositions, for example dentifrice compositions, comprising an orally acceptable vehicle, metal oxide particles having an average particle size of no greater than a dentin tubule and a polymeric adherent material for adhering the metal oxide particles in the dentin tubule. The metal oxide particles have a median particle size of 5 microns or less, and may comprise zinc oxide.

Claims

1. An oral care composition comprising:

an orally acceptable vehicle; and

metal oxide particles comprising zinc oxide;

wherein the metal oxide particles are encapsulated in a mixture of two hydroxyalkyl cellulose polymers having different molecular weight selected from the group consisting of hydroxypropylmethyl cellulose (HPMC), hydroxyethylpropyl cellulose (HEPC) and hydroxybutylmethyl cellulose (HBMC) and;

wherein the metal oxide particles have an average particle size of from 1 to 7 microns.

2. The oral care composition according to claim 1 wherein the metal oxide is zinc oxide.

3. The oral care composition according to claim 1 wherein the metal oxide particles are present in an amount of up to 5% by weight, based on the total weight of the oral care composition.

4. The oral care composition according to claim 3 wherein the metal oxide particles are present in an amount of from 0.5 to 2% by weight, being based on the total weight of the oral care composition.

5. The oral care composition according to claim 1 wherein the mixture of two hydroxyalkyl cellulose polymers comprise at least one polymer selected from poly (ethylene oxide) polymers, linear polyvinylpyrrolidone (PVP) and cross-linked polyvinylpyrrolidone (PVP), polyethylene glycol (PEG)/polypropylene glycol (PPG) copolymer, ethylene oxide (EO)-propylene oxide (PO) block copolymers, ester gum, shellac, pressure sensitive silicone adhesives, methacrylates, or mixtures thereof.

6. The oral care composition according to claim 1 further comprising silica particles which have an average particle size of no greater than a dentin tubule.

7. The oral care composition according to claim 6 wherein the silica particles are present in an amount of up to 10% by weight, based on the total weight of the oral care composition.

8. The oral care composition according to claim 7 wherein the silica particles are present in an amount of from 3 to 6% by weight, based on the total weight of the oral care composition.

9. The oral care composition according to claim 1 which is a dentifrice composition.

10. The oral care composition according to claim 9, which is a toothpaste or a gel.

11. The oral care composition according to claim 1, wherein the composition is formulated into a form selected from a mouth rinse, a gum, a dissolvable lozenge, and a dissolvable film.

12. A method of reducing dental sensitivity comprising applying to the surface of a mammalian tooth an oral care composition of claim 1.

13. A method of protecting dental surfaces from acid-mediated degradation, comprising applying to the surface of a mammalian tooth an oral care composition of claim 1.

14. A method of maintaining or increasing the systemic health of a mammal comprising applying a composition to an oral surface of a mammal at least once a day for a duration of time, wherein the composition comprises:

a. an oral care composition of claim 1, and

b. an agent selected from triclosan;

triclosan monophosphate;

chlorhexidine;

alexidine;

hexetidine;

sanguinarine;

benzalkonium chloride;

salicylanilide;

domiphen bromide;

cetylpyridinium chloride (CPC);

tetradecylpyridinium chloride (TPC);

N-tetradecyl-4-ethylpyridinium chloride (TDEPC);

octenidine;

delmopinol;

octapinol;

nisin;

zinc ion agent;

copper ion agent;

essential oils;

furanones;

bacteriocins, ethyllauroyl arginate, extracts of magnolia, a metal ion source, fluoride, stannous ions, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, extract of sea buckthorn, a peroxide, an enzyme, a Camellia extract, a flavonoid, a flavan, halogenated diphenyl ether, creative, and propolis.

15. A method of occluding a dentin tubule within the surface of a mammalian tooth comprising applying to the tooth surface a composition according to claim 1.

16. The oral care composition according to claim 1, wherein the metal oxide particles further comprises a member of the group consisting of stannous oxide, calcium oxide, copper oxide, iron oxide and mixtures thereof.

17. The oral care composition according to claim 1, wherein the metal oxide particles have a particle size distribution of 3 to 4 microns, a particle size distribution of 5 to 7 microns, a particle size distribution of 3 to 5 microns, a particle size distribution of 2 to 5 microns, or a particle size distribution of 2 to 4 microns.