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Sensation modifying topical composition foam

  • US 9,320,705 B2
  • Filed: 01/08/2009
  • Issued: 04/26/2016
  • Est. Priority Date: 10/25/2002
  • Status: Active Grant
First Claim
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1. A topical composition, comprising a foamable base composition and a hydrocarbon propellant,wherein the foamable base composition is an oil in water emulsion comprising:

  • i. about 6% to about 22% by weight of the foamable base composition of a hydrophobic solvent comprising a non-volatile hydrophobic solvent selected from the group consisting of at least two of isopropyl myristate, a triglyceride and a silicone oil;

    ii. about 0.5% to about 3% by weight of the foamable base composition of a sensation or sensation modifying agent;

    iii. a coal tar;

    iv. about 0.1% to about 5% by weight of the foamable base composition of a polymeric agent, wherein the polymeric agent is selected from the group consisting of a locust bean gum, sodium alginate, sodium caseinate, an egg albumin, a gelatin agar, a carrageenan gum, a xanthan gum, a tragacanth gum, a guar gum, a cationic guar, a hydroxypropyl guar gum, a starch, an amine-bearing polymer, a chitosan, an alginic acid, a hyaluronic acid, a chemically modified starch, a carboxyvinyl polymer, a polyvinylpyrrolidone, a polyvinyl alcohol, a polyacrylic acid polymer, a polymethacrylic acid polymer, a polyvinyl acetate, a polyvinyl chloride polymer, a polyvinylidene chloride polymer, a methylcellulose, a hydroxypropyl cellulose, a hydroxypropyl methylcellulose, a hydroxyethyl cellulose, methylhydroxyethylcellulose, a hydroxyethyl carboxymethylcellulose, a carboxymethyl cellulose, a cationic cellulose, PEG 1000, PEG 4000, PEG 6000, PEG 8000, a sodium carboxymethyl cellulose, a microcrystalline cellulose, a polyacrylate and mixtures of any two or more thereof; and

    v. about 40% to about 90% by weight of the foamable base composition of water;

    wherein the hydrocarbon propellant is selected from the group consisting of butane, propane, isobutane, isobutene and mixtures of any two or more thereof;

    wherein the weight ratio of the foamable base composition to the hydrocarbon propellant ranges from about 100;

    3 to about 100;

    25;

    wherein the topical composition is stored in a pressurized container and upon release expands to form a non-crackling short term stable foam that breaks under mechanical force;

    wherein the foam produces at least one prolonged sensation at a delivery site upon dispensing from an aerosol container for a period of at least about 5 minutes; and

    wherein the prolonged sensation is not primarily due to the propellant or an exothermic reaction.

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