Sensation modifying topical composition foam
First Claim
1. A topical composition, comprising a foamable base composition and a hydrocarbon propellant,wherein the foamable base composition is an oil in water emulsion comprising:
- i. about 6% to about 22% by weight of the foamable base composition of a hydrophobic solvent comprising a non-volatile hydrophobic solvent selected from the group consisting of at least two of isopropyl myristate, a triglyceride and a silicone oil;
ii. about 0.5% to about 3% by weight of the foamable base composition of a sensation or sensation modifying agent;
iii. a coal tar;
iv. about 0.1% to about 5% by weight of the foamable base composition of a polymeric agent, wherein the polymeric agent is selected from the group consisting of a locust bean gum, sodium alginate, sodium caseinate, an egg albumin, a gelatin agar, a carrageenan gum, a xanthan gum, a tragacanth gum, a guar gum, a cationic guar, a hydroxypropyl guar gum, a starch, an amine-bearing polymer, a chitosan, an alginic acid, a hyaluronic acid, a chemically modified starch, a carboxyvinyl polymer, a polyvinylpyrrolidone, a polyvinyl alcohol, a polyacrylic acid polymer, a polymethacrylic acid polymer, a polyvinyl acetate, a polyvinyl chloride polymer, a polyvinylidene chloride polymer, a methylcellulose, a hydroxypropyl cellulose, a hydroxypropyl methylcellulose, a hydroxyethyl cellulose, methylhydroxyethylcellulose, a hydroxyethyl carboxymethylcellulose, a carboxymethyl cellulose, a cationic cellulose, PEG 1000, PEG 4000, PEG 6000, PEG 8000, a sodium carboxymethyl cellulose, a microcrystalline cellulose, a polyacrylate and mixtures of any two or more thereof; and
v. about 40% to about 90% by weight of the foamable base composition of water;
wherein the hydrocarbon propellant is selected from the group consisting of butane, propane, isobutane, isobutene and mixtures of any two or more thereof;
wherein the weight ratio of the foamable base composition to the hydrocarbon propellant ranges from about 100;
3 to about 100;
25;
wherein the topical composition is stored in a pressurized container and upon release expands to form a non-crackling short term stable foam that breaks under mechanical force;
wherein the foam produces at least one prolonged sensation at a delivery site upon dispensing from an aerosol container for a period of at least about 5 minutes; and
wherein the prolonged sensation is not primarily due to the propellant or an exothermic reaction.
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Accused Products
Abstract
This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to foamable pharmaceutical, therapeutic and cosmetic compositions, comprising an active agent, having a sensation or sensation modifying affect on a body surface, upon application. More particularly, the invention relates to foamable compositions comprising: (a) a foamable carrier; (b) at least one sensation or sensation modifying agent, selected from the group of a cooling agent; a warming agent; a relaxing or soothing agent; stimulating or refreshing agent; or mixtures thereof and (c) a propellant at a concentration of about 3% to about 45% by weight of the total composition. The foamable carrier can be an emollient emulsion foamable vehicle, a foamable gel vehicle and can also be a substantially non aqueous foamable vehicle.
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Citations
44 Claims
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1. A topical composition, comprising a foamable base composition and a hydrocarbon propellant,
wherein the foamable base composition is an oil in water emulsion comprising: -
i. about 6% to about 22% by weight of the foamable base composition of a hydrophobic solvent comprising a non-volatile hydrophobic solvent selected from the group consisting of at least two of isopropyl myristate, a triglyceride and a silicone oil; ii. about 0.5% to about 3% by weight of the foamable base composition of a sensation or sensation modifying agent; iii. a coal tar; iv. about 0.1% to about 5% by weight of the foamable base composition of a polymeric agent, wherein the polymeric agent is selected from the group consisting of a locust bean gum, sodium alginate, sodium caseinate, an egg albumin, a gelatin agar, a carrageenan gum, a xanthan gum, a tragacanth gum, a guar gum, a cationic guar, a hydroxypropyl guar gum, a starch, an amine-bearing polymer, a chitosan, an alginic acid, a hyaluronic acid, a chemically modified starch, a carboxyvinyl polymer, a polyvinylpyrrolidone, a polyvinyl alcohol, a polyacrylic acid polymer, a polymethacrylic acid polymer, a polyvinyl acetate, a polyvinyl chloride polymer, a polyvinylidene chloride polymer, a methylcellulose, a hydroxypropyl cellulose, a hydroxypropyl methylcellulose, a hydroxyethyl cellulose, methylhydroxyethylcellulose, a hydroxyethyl carboxymethylcellulose, a carboxymethyl cellulose, a cationic cellulose, PEG 1000, PEG 4000, PEG 6000, PEG 8000, a sodium carboxymethyl cellulose, a microcrystalline cellulose, a polyacrylate and mixtures of any two or more thereof; and v. about 40% to about 90% by weight of the foamable base composition of water; wherein the hydrocarbon propellant is selected from the group consisting of butane, propane, isobutane, isobutene and mixtures of any two or more thereof; wherein the weight ratio of the foamable base composition to the hydrocarbon propellant ranges from about 100;
3 to about 100;
25;wherein the topical composition is stored in a pressurized container and upon release expands to form a non-crackling short term stable foam that breaks under mechanical force; wherein the foam produces at least one prolonged sensation at a delivery site upon dispensing from an aerosol container for a period of at least about 5 minutes; and wherein the prolonged sensation is not primarily due to the propellant or an exothermic reaction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 40, 42, 43)
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21. A method of treating or alleviating a disorder selected from the group consisting of hyperkeratinization, eczema, dandruff, seborrheic dermatitis, psoriasis, atopic dermatitis, and dermatitis, comprising administering topically to a delivery site having the disorder, a foam produced from a composition comprising a foamable base composition and a hydrocarbon propellant,
i. about 6% to about 22% by weight of the foamable base composition of a hydrophobic solvent comprising a non-volatile hydrophobic solvent selected from the group consisting of at least two of isopropyl myristate, a triglyceride and a silicone oil; -
ii. about 0.5% to about 3% by weight of the foamable base composition of a sensation or sensation modifying agent; iii. a coal tar; iv. about 0.1% to about 5% by weight of the foamable base composition of a polymeric agent, wherein the polymeric agent is selected from the group consisting of a locust bean gum, sodium alginate, sodium caseinate, an egg albumin, a gelatin agar, a carrageenan gum, a xanthan gum, a tragacanth gum, a guar gum, a cationic guar, a hydroxypropyl guar gum, a starch, an amine-bearing polymer, a chitosan, an alginic acid, a hyaluronic acid, a chemically modified starch, a carboxyvinyl polymer, a polyvinylpyrrolidone, a polyvinyl alcohol, a polyacrylic acid polymer, a polymethacrylic acid polymer, a polyvinyl acetate, a polyvinyl chloride polymer, a polyvinylidene chloride polymer, a methylcellulose, a hydroxypropyl cellulose, a hydroxypropyl methylcellulose, a hydroxyethyl cellulose, methylhydroxyethylcellulose, a hydroxyethyl carboxymethylcellulose, a carboxymethyl cellulose, a cationic cellulose, PEG 1000, PEG 4000, PEG 6000, PEG 8000, a sodium carboxymethyl cellulose, a microcrystalline cellulose, a polyacrylate and mixtures of any two or more thereof; and v. about 40% to about 90% by weight of the foamable base composition of water; wherein the hydrocarbon propellant is selected from the group consisting of butane, propane, isobutane, isobutene and mixtures of any two or more thereof; wherein the weight ratio of the foamable base composition to the hydrocarbon propellant ranges from about 100;
3 to about 100;
25;wherein the topical composition is stored in a pressurized container and upon release expands to form a non-crackling short term stable foam that breaks under mechanical force; wherein the foam produces at least one prolonged sensation at a delivery site upon dispensing from an aerosol container for a period of at least about 5 minutes; and wherein the prolonged sensation is not primarily due to the propellant or an exothermic reaction. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 41, 44)
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Specification