Methods and systems for determining subject-specific parameters for a neuromodulation therapy
First Claim
1. A method of monitoring a subject, the method comprising:
- monitoring high frequency head vibration, muscle vibration, or speech production using an acoustic sensor mounted in the subject'"'"'s head and coupled to a stimulating and recording circuit contained in an enclosure implanted in the subject;
monitoring head movement and position with respect to gravity using an accelerometer mounted in the patient'"'"'s head and coupled to the stimulating and recording circuit;
delivering a first neuromodulation therapy with the stimulating and recording circuit to manage a neurological symptom of the subject, wherein the first neuromodulation therapy is specified by a first set of parameters derived at least in part from a comparison of a disease state estimate and a reference input corresponding to a target disease state, wherein the disease state estimate is based at least in part on a patient motion signal of the accelerometer and an acoustic signal of the acoustic sensor;
recording the subject'"'"'s response to the first neuromodulation therapy with the stimulating and recording circuit, the subject'"'"'s response to the first neuromodulation therapy being calculated from a first set of data received from the accelerometer communicating with the subject and the acoustic sensor;
wirelessly transmitting the subject'"'"'s response to the first neuromodulation therapy from the stimulating and recording circuit to an external device that is external to the subject'"'"'s body;
delivering a second neuromodulation therapy with the stimulating and recording circuit, the second neuromodulation therapy specified by a second set of parameters, wherein the second set of parameters is defined by at least one parameter of the first set of parameters being automatically changed to a different value to provide the second set of parameters;
recording the subject'"'"'s response to the second neuromodulation therapy with the stimulating and recording circuit, the subject'"'"'s response to the second neuromodulation therapy being calculated from a second set of data received from the accelerometer and the acoustic sensor;
wirelessly transmitting the subject'"'"'s response to the second neuromodulation therapy from the stimulating and recording circuit to the external device; and
monitoring the responses to the first neuromodulation therapy and the second neuromodulation therapy from the external device.
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Abstract
A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
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Citations
13 Claims
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1. A method of monitoring a subject, the method comprising:
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monitoring high frequency head vibration, muscle vibration, or speech production using an acoustic sensor mounted in the subject'"'"'s head and coupled to a stimulating and recording circuit contained in an enclosure implanted in the subject; monitoring head movement and position with respect to gravity using an accelerometer mounted in the patient'"'"'s head and coupled to the stimulating and recording circuit; delivering a first neuromodulation therapy with the stimulating and recording circuit to manage a neurological symptom of the subject, wherein the first neuromodulation therapy is specified by a first set of parameters derived at least in part from a comparison of a disease state estimate and a reference input corresponding to a target disease state, wherein the disease state estimate is based at least in part on a patient motion signal of the accelerometer and an acoustic signal of the acoustic sensor; recording the subject'"'"'s response to the first neuromodulation therapy with the stimulating and recording circuit, the subject'"'"'s response to the first neuromodulation therapy being calculated from a first set of data received from the accelerometer communicating with the subject and the acoustic sensor; wirelessly transmitting the subject'"'"'s response to the first neuromodulation therapy from the stimulating and recording circuit to an external device that is external to the subject'"'"'s body; delivering a second neuromodulation therapy with the stimulating and recording circuit, the second neuromodulation therapy specified by a second set of parameters, wherein the second set of parameters is defined by at least one parameter of the first set of parameters being automatically changed to a different value to provide the second set of parameters; recording the subject'"'"'s response to the second neuromodulation therapy with the stimulating and recording circuit, the subject'"'"'s response to the second neuromodulation therapy being calculated from a second set of data received from the accelerometer and the acoustic sensor; wirelessly transmitting the subject'"'"'s response to the second neuromodulation therapy from the stimulating and recording circuit to the external device; and monitoring the responses to the first neuromodulation therapy and the second neuromodulation therapy from the external device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification