Sample distribution system and process

• US 9,321,048 B2
• Filed: 08/15/2013
• Issued: 04/26/2016
• Est. Priority Date: 08/15/2012
• Status: Active Grant

• Current Assignee: Integra Biosciences AG
• Original Assignee: Integra Biosciences AG
• Inventors: Mettier, Ivo, Keene, Richard Larry
• Primary Examiner(s): Macchiarolo, Peter
• Assistant Examiner(s): Keramet-Amircolai, Mohammed E
• Application Number:
  US13/967,481
• Publication Number:
  US 20140047931A1
• Time in Patent Office: 985 Days
• Field of Search: 738/630.1
• US Class Current: 1/1
• CPC Class Codes: B01L 2200/028 Modular arrangements
• CPC Class Codes: B01L 2300/023 Sending and receiving of information, e.g. using bluetooth
• CPC Class Codes: B01L 3/021 Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
• CPC Class Codes: B01L 3/0237 Details of electronic control, e.g. relating to user interface
• CPC Class Codes: B01L 9/54 Supports specially adapted for pipettes and burettes automated pipetting stations G01N35/10
• CPC Class Codes: G01N 35/00871 Communications between instruments or with remote terminals
• CPC Class Codes: G01N 35/1011 Control of the position or alignment of the transfer device
• CPC Class Codes: G01N 35/1065 Multiple transfer devices

Abstract

On the one hand the invention relates to a distribution apparatus 41 for hand held distribution of fluid samples with a data carrier and a first communication interface. On the other hand it concerns a positioning device 21 comprising a first holder 23 adapted for holding the distribution apparatus 41, a second holder 25 adapted for holding a target container 63, an actuator for effecting a relative movement of the first and the second holder 23, 25, and a second communication interface. These two components are part of a sample distribution system 11 which is also subject matter of the invention, including its use in a process for sample distribution. A relevant aspect of the invention is that the data carrier of the distribution apparatus contains information determining the operation of the actuator. The first and the second communication interfaces are configured for the transmission of said information from the distribution apparatus 41 to the positioning device 21, and the positioning device 21 is configured for effecting operation of the actuator as determined by the information.

Claims

1. A sample distribution system comprising

a hand-held, programmable, electronic pipettor for hand held distribution of fluid samples, comprising a user interface, a data carrier and a first electronic data communication interface, and

a positioning device comprising a first holder adapted to removably hold the hand-held, electronic pipettor, a second holder adapted to removably hold a target container, at least two electronically controlled motors for effecting a relative movement of the first and the second holders, and a second electronic data communication interface,

wherein the data carrier on the hand-held, electronic pipettor contains information determining some or all of the operation of the electronically controlled motors on the positioning device and the user interface is configured for manual entry, alteration, or selection of the information, part thereof, or a precursor thereof,

the first and the second electronic data communication interfaces are configured for transmission of said information from the hand-held, electronic pipettor to the positioning device, and

the positioning device is configured to receive the information from the electronic pipettor and to control operation of the motors as determined by information received from the electronic pipettor.

4. A sample distribution system according to claim 1, wherein

the first holder and the second holder are movable relative to each other in a first and a second direction to allow samples to be transferred from the pipettor to the target container (63),

the movements in the first and the second direction are linear movements,

the first direction is perpendicular to the second direction.

5. A sample distribution system according to claim 1, wherein

the positioning device comprises a third holder for holding a source container,

the first holder and the second holder and/or the first holder and the third holder are moveable relative to each other in a first and a second direction to allow samples to be transferred from the source container to the target container,

the movement in the first and the second direction are linear movements, and

the first direction is perpendicular to the second direction.

6. A sample distribution system according to claim 4 wherein the first holder and the second holder are movable linearly relative to each other in a third direction which is perpendicular to the first and the second direction.

7. A sample distribution system according to claim 1 wherein the first electronic data communication interface and second electronic data communication interface communicate wirelessly.

8. A sample distribution system according to claim 1 wherein the hand-held, electronic pipettor is a multi-channel pipettor.

9. A sample distribution system according to claim 1 wherein the hand-held, electronic pipettor contains a master microcontroller and the positioning device includes a slave microcontroller.

10. A sample distribution system according to claim 1 wherein said electronically controlled motor is a stepper motor.

11. A sample distribution system according to claim 1 wherein the target container is moveable over the source container.

14. A hand-held electronic pipettor comprising a data carrier containing information determining the operation of a positioning device according claim 5 and an electronic data communication interface configured for transmitting the information to the positioning device.

15. A hand-held, electronic pipettor according to claim 14, comprising a user interface configured for manual entry, alteration, or selection of the information, part thereof, or a precursor thereof.

2. A positioning device comprising

a first holder adapted to removeably hold a hand-held electronic pipettor for hand held distribution of fluid samples,

a second holder adapted to removeably hold a target container,

an electronic data communication interface,

at least two electronically controlled motors for effecting a relative movement of the first holder and the second holder, and

a slave microcontroller;

wherein the positioning device is configured for receiving via the electronic data communication interface information from the hand-held electronic pipettor, said information being used by the slave microcontroller to control operation of the motors and to move and position the first holder relative to the second holder.

12. A positioning device according to claim 2, wherein

the first holder and the second holder are movable relative to each other in a first direction and in a second direction to allow samples to be transferred from the electronic pipettor to the target container,

wherein the movement in the first direction and the movement in the second direction are linear movements, and

the first direction is perpendicular to the second direction.

13. A positioning device according to claim 2, comprising a third holder for holding a source container, wherein

the first holder and the second holder and/or the first holder and the third holder are moveable relative to each other in a first and a second direction to allow samples to be transferred from the source container to the target container,

the movement in the first and the second direction are linear movements, and

the first direction is perpendicular to the second direction.

16. A positioning device according to claim 12 wherein the first holder and the second holder are movable linearly relative to each other in a third direction which is perpendicular to the first and the second direction.

17. A positioning device according to claim 13 wherein the target container is moveable over the source container.

3. A sample distribution process comprising the steps of:

providing a hand-held, programmable electronic pipettor comprising a data carrier,

providing a positioning device comprising a first holder for holding the electronic pipettor, a second holder for holding a target container, and at least two electronically controlled motors for effecting a relative movement of the first and the second holder,

storing information on a data carrier of a hand-held programmable electronic pipettor, said information coordinating the relative movement of the first and second holders on the positioning device and the pipetting action of the electronic pipettor,

placing the hand-held programmable electronic pipettor in a first holder on a positioning device;

transmitting the information electronically from the hand-held, programmable electronic pipettor to the positioning device,

using the transmitted information to control the operation of at least two motors, thereby effecting the relative movement of the first holder holding the electronic pipettor and the second holder holding the target container and

using the information on the data carrier to control operation of the electronic pipettor and transfer fluid samples from the electronic pipettor to the target container.

18. A sample distribution process according to claim 3, wherein

the hand-held programmable electronic pipettor comprises a user interface, and

the information, part thereof, or a precursor thereof is entered, altered, or selected manually via the user interface.

19. A sample distribution process according to claim 3, wherein the step of using the transmitted information to control the operation of the one or more motors, thereby effecting the relative movement of the first holder holding the electronic pipettor and the second holder holding the target container comprises:

moving the first holder and the second holder relative to each other in a first direction and in a second direction,

the movement in the first and the second direction are linear movements, and

the first direction is perpendicular to the second direction.

20. A sample distribution process according to claim 3, wherein

the positioning device comprises a third holder holding a source container,

the first holder and the second holder and/or the first holder and the third holder are moved relative to each other in a first direction and in a second direction, liquid samples being transferred in the process from the source container to the target container,

the movement in the first direction and in the second direction are linear movements, and

the first direction is perpendicular to the second direction.

21. A sample distribution process according to claim 3,

wherein storing, altering and/or selecting the information on the data carrier is done before the distribution apparatus is removably mounted in the first holder.