Process and device for delivery of fluid by chemical reaction

• US 9,321,581 B2
• Filed: 10/15/2013
• Issued: 04/26/2016
• Est. Priority Date: 10/12/2012
• Status: Active Grant

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Bennison, Corrie, Muenzer, Chris, Blum, Tim, McKenzie, Chris, Madland, Steve, Ellis, Jeff, Heintz, Amy, Kaseman, Brian
• Primary Examiner(s): Nicolas, Frederick C
• Assistant Examiner(s): Zadeh, Bob
• Application Number:
  US14/054,567
• Publication Number:
  US 20140103075A1
• Time in Patent Office: 924 Days
• Field of Search: 222/113, 222/131, 222/146.2, 222/389
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2005/2026 Semi-automatic, e.g. user activated piston is assisted by additional source of energy
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/155 pressurised by gas introduced into the reservoir
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: B65D 83/14 for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
• CPC Class Codes: B65D 83/60 Contents and propellant separated
• CPC Class Codes: B65D 83/64 by piston
• CPC Class Codes: B65D 83/643 the propellant being generated by a chemical or electrochemical reaction for pressure gas in portable fire extinguishers A62C13/02

Abstract

Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. Preferred devices typically include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a barrier between the upper chamber and the lower chamber. When the barrier is broken, reagents in the upper chamber and the lower chamber are mixed together to generate the gas.

Claims

1. A process for delivering a high-viscosity fluid by chemical reaction, comprising:

actuating a plunger positioned in a barrel of a device, the plunger separating a reagent chamber containing a first reagent from a reaction chamber containing a second reagent; and

mixing the first reagent and the second reagent in response to the actuating to initiate a chemical reaction in the reaction chamber of the device, the reaction chamber including a piston;

wherein the plunger moves away from the piston in response to the actuating;

wherein gas generated by the chemical reaction moves the piston into a fluid chamber containing the high-viscosity fluid to deliver the high-viscosity fluid.

2. The process of claim 1, wherein the actuating causes rotational movement of the plunger.

3. The process of claim 1, wherein the plunger and a push button of the device form at least a portion of the reagent chamber, the plunger is actuated in response to a movement of the push button, and the actuating causes axial and rotational movement of the plunger.

4. The process of claim 3, wherein a direction of the axial movement of the plunger is opposite a direction of the movement of the push button.

5. The process of claim 3, wherein the plunger comprises a central body having a plurality of radially extending lugs, the push button includes channels for receiving the lugs of the plunger, and the process further includes pushing, with a spring, the lugs of the plunger into the channels of the push button in response to the movement of the push button.

6. The process of claim 1, further including biasing, with a spring, the plunger away from the piston.

7. The process of claim 1, wherein the first reagent is a liquid reagent and the second reagent is a dry reagent.

8. A device for delivering a fluid by chemical reaction, comprising:

a barrel containing a reagent chamber, a reaction chamber, and a fluid chamber;

wherein the reagent chamber is located within a push button member at a top end of the barrel;

a plunger separating the reagent chamber from the reaction chamber;

a spring biased to push the plunger into the reagent chamber when the push button member is depressed; and

a piston separating the reaction chamber from the fluid chamber, wherein the piston moves in response to pressure generated in the reaction chamber.

9. The device of claim 8, wherein the push button member comprises a sidewall closed at an outer end by a contact surface, a lip extending outwards from an inner end of the sidewall, and a sealing member proximate a central portion on an exterior surface of the sidewall.

10. The device of claim 8, wherein the plunger comprises a central body having lugs extending radially therefrom, and a sealing member on an inner end which engages a sidewall of the reaction chamber.

11. The device of claim 10, wherein an interior surface of the push button member includes channels for the lugs.

12. The device of claim 8, wherein the reaction chamber is divided into a mixing chamber and an arm by an interior radial surface, the interior radial surface having an orifice, and the piston being located at the end of the arm.

13. The device of claim 12, wherein the mixing chamber includes a gas permeable filter covering the orifice.

14. A device for delivering a fluid by chemical reaction, the device comprising:

a first chamber containing a first reagent;

a second chamber containing a second reagent;

a push button forming at least a portion of the first chamber;

a plunger positioned between the first chamber and the second chamber;

a piston positioned in the second chamber; and

a biasing member positioned in the second chamber between the piston and the plunger,

the device having a first state and a second state, wherein in the first state the plunger blocks mixing of the first reagent and the second reagent, and in the second state the biasing member biases the plunger into the first chamber in response to a depression of the push button to allow mixing of the first reagent and the second reagent to initiate a gas-generating chemical reaction in the second chamber of the device operative to move the piston, wherein the movement of the piston forces the fluid to exit the device.

15. The device of claim 14, wherein in the first state the plunger forms a sealing surface between the first chamber and the second chamber to separate the first reagent from the second reagent.

16. The device of claim 14, further including a sidewall forming an interior space and including an interior stop surface, the push button being positioned in the interior space formed by the sidewall and being configured to move axially relative to the sidewall to transition the device from the first state to the second state, the push button including a lip configured to engage the interior stop surface of the sidewall.

17. The device of claim 14, wherein the plunger comprises a central body having a plurality of radially extending lugs, the plunger comprises a sealing member positioned on an outer surface of the central body, and in the first state of the device the sealing member engages a sidewall of the second chamber.

18. The device of claim 17, wherein an interior surface of the push button includes channels for receiving the radially extending lugs in the second state of the device.

19. The device of claim 14, further including an interior radial surface dividing the second chamber into a mixing chamber and an arm, the piston being positioned in the arm, and the spring being seated on the interior radial surface.