Wireless, implantable electro-encephalography system

• US 9,326,720 B2
• Filed: 02/09/2012
• Issued: 05/03/2016
• Est. Priority Date: 02/09/2011
• Status: Active Grant

• Current Assignee: Charles Stark Draper Laboratory Incorporated
• Original Assignee: Charles Stark Draper Laboratory Incorporated
• Inventors: McLaughlin, Bryan
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): WESTON, TIFFANY C
• Application Number:
  US13/369,724
• Publication Number:
  US 20120203079A1
• Time in Patent Office: 1,545 Days
• Field of Search: 600/378, 600/544, 600/545, 600/546
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

An electro-encephalography system includes an internal device for implantation below a scalp and above a skull of a patient, and an external device to be worn or carried outside the patient'"'"'s body. The internal device includes a first electrode for receiving neurological signals originating from the patient'"'"'s brain and a second electrode for receiving artifacts originating from sources other than the patient'"'"'s brain. The external device includes a processing unit for receiving data from the internal device, mitigating the effects of the artifacts, and determining a neurological state of the patient. A therapy device is included to provide a therapy to the patient based on the patient'"'"'s neurological state.

Claims

1. An electro-encephalography system, comprising:

(a) an internal device for implantation below a scalp and above a skull of a patient, the internal device comprising;

(i) a first electrode disposed on a first side of the internal device for receiving a first signal comprising neurological signals originating from the patient'"'"'s brain and artifacts originating from sources other than the patient'"'"'s brain, the first signal comprising a first ratio of the neurological signals to the artifacts;

(ii) a second electrode disposed on a second side of the internal device for receiving a second signal comprising the artifacts; and

(iii) a therapy device for providing therapy to the patient; and

(b) an external device in wireless communication with the internal device, the external device to be worn or carried outside the patient'"'"'s body, the external device comprising a processing unit for;

(i) providing power to the internal device;

(ii) receiving data from the first and second electrodes, the data comprising the first and second signals;

(iii) processing the received data by subtracting at least a portion of the second signal received from the second electrode disposed on the second side of the internal device from the first signal received from the first electrode disposed on the first side of the internal device;

(iv) determining a neurological state of the patient based on the processed signal; and

(v) transmitting instructions to the therapy device for providing therapy to the patient according to the neurological state.

2. The system of claim 1, wherein the processing unit records at least one of the processed signal or the data received from the first and second electrodes.

3. The system of claim 1, wherein the first side of the internal device is opposite the second side of the internal device.

4. The system of claim 1, wherein the therapy device comprises at least one of the first electrode or the second electrode.

5. The system of claim 1, wherein the therapy provided to the patient is selected from the group consisting of electrical stimulation, acoustic stimulation, RF stimulation, ultrasound stimulation, magnetic stimulation, electro-magnetic stimulation, photon stimulation, and a pharmaceutical compound.

6. The system of claim 1, wherein the second electrode is configured for implantation in a muscle artifact location.

7. The system of claim 1, wherein the processing unit determines the neurological state of the patient based on data received from the first and second electrodes in response to stimulation of the patient'"'"'s brain.

8. The system of claim 1, wherein the neurological state is indicative of a propensity for a seizure.

9. The system of claim 1, wherein the processing unit provides trans-cutaneous wireless power to the internal device.

10. The system of claim 1, wherein the artifacts originate from a source selected from the group consisting of the patient'"'"'s scalp, the patient'"'"'s eyes, electromyographic signals, and motion.

11. The system of claim 1, wherein the external device comprises an earpiece.

12. The system of claim 1, wherein the external device comprises at least one sensor for sensing at least one of the patient'"'"'s temperature, cardiac pulse-rate, or tissue oxygenation level.

13. The system of claim 1, wherein the external device comprises at least one inertial sensor for sensing at least one of a heading, a motion, or an orientation of the processing unit.

14. The system of claim 1, wherein the external device comprises a temperature sensor for measuring the patient'"'"'s temperature.

15. The system of claim 1, wherein the external device comprises an audible alarm for warning the patient of an onset of a seizure.

16. The system of claim 1, wherein the external device comprises at least one of a modem or a transceiver.