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Mucus penetrating gene carriers

  • US 9,327,037 B2
  • Filed: 02/08/2012
  • Issued: 05/03/2016
  • Est. Priority Date: 02/08/2011
  • Status: Active Grant
First Claim
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1. A composition for delivery of nucleic acid comprising nanoparticles having an average diameter of between 5 and 500 nm, comprisinga) a complex formed by the ionic association of one or more nucleic acids and one or more polycationic polymers, andb) one or more mucus-resistant/diffusive graft co-polymers non-covalently associated to the complex,wherein the one or more mucus-resistant/diffusive graft co-polymers comprise a polycationic polymer backbone having multiple mucus-resistant/diffusive polymer side chains covalently attached thereto,wherein the ratio of mucus-resistant/diffusive polymer side chains to the polycationic backbone is between 15:

  • 1 and 60;

    1, or wherein the one or more polycationic polymers and one or more mucus-resistant/diffusive graft co-polymers are present in a molar ratio of between 1;

    5 and 5;

    1, andwherein the nanoparticles have a near neutral surface charge between about −

    10 mV and about +10 mV.

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