Soluble implantable device comprising polyelectrolyte with hydrophobic counterions
First Claim
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1. An implantable device comprising a biosoluble body structure and optionally comprising a coating deposited on the body structure of the implantable device, the biosoluble body structure comprising:
- a complex comprising a polyelectrolyte and a counterion, the polyelectrolyte being poly(2-acrylamido-2-methyl-1-propane sulfonic acid) (PAMPS), sulfonated poly(ether ether ketone) (SPEEK), poly(acryloxyethyltrimethyl ammonium chloride), poly(methacryloxy(2-hydroxy)propyltrimethyl ammonium chloride), or a combination thereof;
wherein the implantable device is selected from the group consisting of stents, stent-grafts, catheters, grafts, pacemakers, defibrillators, leads for pacemakers, leads for defibrillators, electrodes for pacemakers, electrodes for defibrillators, artificial heart valves, anastomotic clips, arterial closure devices, patent foramen ovale closure devices, and cerebrospinal fluid shunts.
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Abstract
The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.
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Citations
20 Claims
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1. An implantable device comprising a biosoluble body structure and optionally comprising a coating deposited on the body structure of the implantable device, the biosoluble body structure comprising:
a complex comprising a polyelectrolyte and a counterion, the polyelectrolyte being poly(2-acrylamido-2-methyl-1-propane sulfonic acid) (PAMPS), sulfonated poly(ether ether ketone) (SPEEK), poly(acryloxyethyltrimethyl ammonium chloride), poly(methacryloxy(2-hydroxy)propyltrimethyl ammonium chloride), or a combination thereof;
wherein the implantable device is selected from the group consisting of stents, stent-grafts, catheters, grafts, pacemakers, defibrillators, leads for pacemakers, leads for defibrillators, electrodes for pacemakers, electrodes for defibrillators, artificial heart valves, anastomotic clips, arterial closure devices, patent foramen ovale closure devices, and cerebrospinal fluid shunts.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of fabricating an implantable device, comprising
forming a biosoluble body structure comprising: a complex comprising a polyelectrolyte and a counterion, the polyelectrolyte being poly(2-acrylamido-2-methyl-1-propane sulfonic acid) (PAMPS), sulfonated poly(ether ether ketone) (SPEEK), poly(acryloxyethyltrimethyl ammonium chloride), poly(methacryloxy(2-hydroxy)propyltrimethyl ammonium chloride, or a combination thereof;
wherein the implantable device is selected from the group consisting of stents, stent-grafts, catheters, grafts, pacemakers, defibrillators, leads for pacemakers, leads for defibrillators, electrodes for pacemakers, electrodes for defibrillators, artificial heart valves, anastomotic clips, arterial closure devices, patent foramen ovale closure devices, and cerebrospinal fluid shunts.- View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
Specification