Methods and systems for treating a medical condition by promoting neural remodeling within the brain

• US 9,327,069 B2
• Filed: 03/29/2006
• Issued: 05/03/2016
• Est. Priority Date: 12/21/2004
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Foster, Allison M., Carbunaru, Rafael, Jaax, Kristen N., Whitehurst, Todd K.
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): D ABREU, MICHAEL JOSEPH
• Application Number:
  US11/393,565
• Publication Number:
  US 20060178709A1
• Time in Patent Office: 3,688 Days
• Field of Search: 607/45, 607/46, 607/116
• US Class Current: 1/1
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula

Abstract

Methods of treating a medical condition include applying at least one stimulus to a stimulation site within the brain of a patient with an implanted stimulator in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient. Systems for treating a medical condition include an implantable stimulator configured to apply at least one stimulus to a stimulation site within the brain of a patient in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient.

Claims

1. A method of treating a medical condition of a patient, said method comprising:

generating an electrical stimulus in accordance with one or more stimulation parameters and

applying said electrical stimulus to a stimulation site of a brain of said patient to decrease the relative excitement between neurons that are the source of said medical condition and neural tissue surrounding said neurons, thereby inducing said neurons to break synaptic contacts and revert to a juvenile phenotype.

2. The method of claim 1, further comprising sensing at least one indicator related to said medical condition and using said at least one sensed indicator to adjust said one or more stimulation parameters.

3. The method of claim 2, wherein said at least one indicator comprises at least one or more of an electrical activity of said brain, a chemical level of said brain, a neurotransmitter level, a hormone level, and a medication level.

4. The method of claim 1, wherein said stimulation site comprises at least one or more of a temporal lobe, cerebral ventricle, structure within a limbic system, pituitary gland, brainstem, and cerebral cortex.

5. The method of claim 1, wherein said medical condition comprises at least one or more of autism, a psychological disorder, a neurodegenerative disease, a chromosomal abnormality, a bad habit, and an injury to said brain.

6. The method of claim 1, further comprising:

adjusting said one or more stimulation parameters;

generating another electrical stimulus in accordance with said adjusted one or more stimulation parameters;

applying said other electrical stimulus to said one or more neurons to facilitate redifferentiation of said one or more neurons.

7. The method of claim 1, wherein said one or more stimulation parameters comprises a frequency greater than 100 Hz.

8. The method of claim 1, wherein said stimulation site includes said neurons, wherein excitement of the neurons is decreased by the application of said electrical stimulus.

9. The method of claim 1, wherein said stimulation site includes said surrounding neural tissue, wherein the strength of the connection of neurons within said neural tissue is strengthened.