Electronically and remotely controlled pill and system for delivering at least one medicament

• US 9,327,076 B2
• Filed: 08/26/2013
• Issued: 05/03/2016
• Est. Priority Date: 08/27/2004
• Status: Active Grant

• Current Assignee: Progenity, Inc. (Athyrium Capital Management LP)
• Original Assignee: Medimetrics Personalized Drug Delivery B.V.
• Inventors: Trovato, Karen I, Spekowius, Gerhard
• Primary Examiner(s): Berdichevsky, Aarti B
• Application Number:
  US14/010,090
• Publication Number:
  US 20130345505A1
• Time in Patent Office: 981 Days
• Field of Search: 604/67, 604/151, 604/48, 604/500, 604/103.01
• US Class Current: 1/1
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

An electronically and remotely controlled pill (500) or medicament delivery system is provided. The pill (500) includes a housing (102); a medicament reservoir (104) for storing a medicament; an electronically controlled release valve or hatch (106) for dispensing one or more medicaments stored in the medicament reservoir (104) while traversing the gastrointestinal tract; control and timing circuitry (108) for opening and closing the valve (106); and a battery (109). The control and timing circuitry (108) opens an closes the valve (106) throughout a dispensing time period in accordance with a preset dispensing timing pattern which is programmed within the control and timing circuitry (108). RF communication circuitry receives control signals for remotely overriding the preset dispensing timing pattern, reprogramming the control and timing circuitry (108) or terminating the dispensing of the medicament within the body. The pill (500) includes an RFID tag (508) for tracking, identification, inventory and other purposes.

Claims

1. A medicament delivery system for dispensing a medicament to a gastrointestinal tract of a body, said system comprising:

a housing;

an opening in the housing;

a reservoir for storing said medicament within said housing, the reservoir being in fluid communication with the opening;

a pressure mechanism disposed in the housing for applying pressure to the reservoir to direct the medicament toward the opening;

control and timing circuitry programmed with a dispensing timing pattern and comprising a clock, wherein the timing circuitry is adapted to transmit a release signal according to the timing pattern and the clock independent of a sensed physiological parameter of the gastrointestinal tract and independent of a contemporaneous signal from outside the body; and

a release controller for receiving the release signal and controlling a release of the medicament from the reservoir.

2. The system according to claim 1, further comprising at least one antenna and RF communication circuitry for receiving RF control signals to perform an action selected from the group consisting of reprogramming the control and timing circuitry with another dispensing timing pattern, terminating the dispensing of said medicament, dispensing another medicament, changing the dispensing timing pattern, and dispensing said medicament according to a person'"'"'s vitals.

3. The system according to claim 2, further comprising a soluble membrane encapsulating said at least one antenna.

4. The system according to claim 1, further comprising a piezo-electric element capable of being vibrated at at least one predetermined frequency.

5. The system according to claim 4, further comprising a data structure for correlating said at least one predetermined frequency with an action, and wherein said action is selected from the group consisting of reprogramming the control and timing circuitry with another dispensing timing pattern, terminating the dispensing of said medicament, dispensing another medicament, changing the dispensing timing pattern, and dispensing said medicament according to a person'"'"'s vitals.

6. The system according to claim 1, further comprising a transmitter.

7. The system according to claim 1, further comprising an RFID tag.

8. The system according to claim 1, wherein said control and timing circuitry comprises a start timer mechanism wherein said start timer mechanism transmits a signal to said timing circuitry for clocking a dispensing time period, and wherein said timing circuitry transmits a signal to said release controller for dispensing said medicament substantially according to said dispensing timing pattern during said dispensing time period.

9. The system according to claim 1, wherein said dispensing timing pattern correlates an approximate quantity of said medicament to be dispensed during each moment of time during a dispensing time period.

10. The system according to claim 1, further comprising another reservoir for storing another medicament.

11. The system according to claim 1, further comprising a dosage management system for relaying commands to said control and timing circuitry for controlling the dispensing of said medicament in accordance with pre-obtained information selected from the group consisting of weather information, barometric reading, pollen count information and patient-related information.

12. The system according to claim 1, further comprising communication means for communicating with an imaging system, wherein said medicament is dispensed in synchronization with said imaging system.

13. The system of claim 1, further comprising a check valve disposed in the opening.

14. The system of claim 1, wherein the pressure mechanism is a spring.

15. The system of claim 1, wherein the reservoir comprises a micro-syringe comprising a plunger and the pressure mechanism applies a pressure to the plunger.

16. A medicament treatment kit comprising:

a container enclosing a plurality of medicament delivery systems for delivering a medicament to a body, while traversing a gastrointestinal tract of the body, wherein each system comprises;

a housing having an opening disposed therein;

a reservoir for storing said medicament within said housing and in fluid communication with the opening;

a pressure mechanism disposed in the housing for applying pressure to the reservoir to direct the medicament toward the opening;

control and timing circuitry programmed with a dispensing timing pattern and comprising a clock, wherein the timing circuitry is adapted to transmit a release signal according to the timing pattern and the clock independent of a sensed physiological parameter of the gastrointestinal tract and independent of a contemporaneous signal from outside the body;

a release controller for receiving the release signal and controlling a release of the medicament from the reservoir; and

a schedule indicating when each of the medicament delivery systems is to be taken.

17. The kit according to claim 16, further comprising at least one antenna and RF communication circuitry for receiving RF control signals instructing said system to perform an action, and wherein said action is selected from the group consisting of reprogramming the control and timing circuitry with another dispensing timing pattern, terminating the dispensing of said medicament, dispensing another medicament, changing the dispensing timing pattern, and dispensing said medicament according to a person'"'"'s vitals.

18. The kit according to claim 17, further comprising a soluble membrane encapsulating said at least one antenna.

19. The kit according to claim 16, further comprising a piezo-electric element capable of being vibrated at at least one predetermined frequency.

20. The kit according to claim 19, further comprising a data structure for correlating said at least one predetermined frequency with an action, and wherein said action is selected from the group consisting of reprogramming the control and timing circuitry with another dispensing timing pattern, terminating the dispensing of said medicament, dispensing another medicament, changing the dispensing timing pattern, and dispensing said medicament according to a person'"'"'s vitals.

21. The kit according to claim 16, wherein each system further comprises an RFID tag.

22. The kit according to claim 16, wherein said control and timing circuitry comprises a start timer mechanism, wherein said start timer mechanism transmits a signal to said timing circuitry for clocking a dispensing time period, and wherein said timing circuitry transmits a signal to said release controller for dispensing said medicament substantially according to said dispensing timing pattern during said dispensing time period.

23. The kit according to claim 16, wherein said dispensing timing pattern correlates an approximate quantity of said medicament to be dispensed during each moment of time during a dispensing time period.

24. The kit according to claim 16, further comprising another reservoir for storing another medicament.

25. The kit of claim 16, further comprising a check valve disposed in the opening.

26. The kit of claim 16, wherein the pressure mechanism is a spring.

27. The kit of claim 16, wherein the reservoir comprises a micro-syringe comprising a plunger and the pressure mechanism applies a pressure to the plunger.