Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods

• US 9,327,121 B2
• Filed: 09/07/2012
• Issued: 05/03/2016
• Est. Priority Date: 09/08/2011
• Status: Active Grant

• Current Assignee: Nevro Corporation
• Original Assignee: Nevro Corporation
• Inventors: Thacker, James R., Alataris, Konstantinos, Gliner, Bradford Evan
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US13/607,617
• Publication Number:
  US 20130066411A1
• Time in Patent Office: 1,334 Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/06 for high-frequency therapy
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36075 Headache or migraine
• CPC Class Codes: A61N 1/36157 Current A61N1/3616 takes precedence
• CPC Class Codes: A61N 1/3616 Voltage density or current density
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration

Abstract

Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 100 KHz may be applied to the patient'"'"'s spinal cord region from an epidural location to address phantom limb pain without creating paresthesia in the patient.

Claims

1. A method for treating phantom limb pain in a patient, exclusive of phantom limb pain associated with total body pain, comprising:

configuring a signal generator to generate and deliver a phantom limb pain therapy signal to a target location of the patient'"'"'s spinal cord from an epidural location via at least one implantable signal delivery device coupled to the signal generator,

wherein at least a portion of the therapy signal has a frequency in a frequency range of from 1.5 kHz to 100 kHz, includes pulses with a pulse width in a pulse width range of 10 microseconds to 333 microseconds, and has an amplitude in an amplitude range of 0.1 mA to 20 mA, which at least partially alleviates the phantom limb pain, exclusive of phantom limb pain associated with total body pain, without generating paresthesia in the patient.

2. The method of claim 1 wherein the therapy signal has a frequency of from about 5 kHz to about 15 kHz.

3. The method of claim 1 wherein the therapy signal has a frequency of from about 3 kHz to about 15 kHz.

4. The method of claim 1 wherein the therapy signal has a frequency of from about 3 kHz to about 20 kHz.

5. The method of claim 1 wherein the therapy signal has a frequency of from about 3 kHz to about 10 kHz.

6. The method of claim 1 wherein the therapy signal has a frequency of about 10 kHz.

7. The method of claim 1 wherein the target location is at a vertebral level of from about C2 to about C4 to treat phantom upper limb pain.

8. The method of claim 1 wherein the target location is at a vertebral level of from about T7 to about T10 to treat phantom lower limb pain.

9. The method of claim 1 wherein the target location is

(a) at a vertebral level of from about C2 to about C4 to treat phantom upper limb pain;

or

(b) at a vertebral level of from about T7 to about T10 to treat phantom lower limb pain, or;

(c) both (a) and (b).

10. The method of claim 1, wherein the at least one signal delivery device includes a percutaneous lead having one or more electrodes disposed toward a distal end of the percutaneous lead.

11. The method of claim 1, wherein configuring the signal generator includes programming the signal generator.

12. The system of claim 1, wherein the pulse width range is between 25 microseconds and 166 microseconds.

13. The method of claim 1 wherein the portion of the electrical therapy signal is biphasic.

14. The method of claim 1 wherein the pulse width range is 30 microseconds to 35 microseconds.

15. The method of claim 1 wherein the frequency range is 5 kHz to 15 kHz, the pulse width range is 30 microseconds to 35 microseconds, and the amplitude range is 0.5 mA to 10 mA.