Sensor head for use with implantable devices
First Claim
1. An implantable continuous glucose sensor system configured for implantation in a host, the system comprising:
- an electrode comprising an electroactive surface, wherein the electrode is configured for implantation and is configured to generate in vivo a signal indicative of glucose concentration in a host;
a membrane comprising;
a first domain configured to reduce a flux of glucose therethrough;
a second domain comprising an enzyme configured to react with glucose to produce a measured species, wherein the second domain is located less distant to the electroactive surface than the first domain; and
a third domain comprising an architecture that permits access to the electroactive surface only for species that have a molecular weight less than or about equal to a molecular weight of the measured species, wherein the third domain is located less distant to the electroactive surface than the second domain; and
sensor electronics operably connected to the electrode and configured to measure the signal from the electrode.
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Abstract
The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.
1011 Citations
7 Claims
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1. An implantable continuous glucose sensor system configured for implantation in a host, the system comprising:
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an electrode comprising an electroactive surface, wherein the electrode is configured for implantation and is configured to generate in vivo a signal indicative of glucose concentration in a host; a membrane comprising; a first domain configured to reduce a flux of glucose therethrough; a second domain comprising an enzyme configured to react with glucose to produce a measured species, wherein the second domain is located less distant to the electroactive surface than the first domain; and a third domain comprising an architecture that permits access to the electroactive surface only for species that have a molecular weight less than or about equal to a molecular weight of the measured species, wherein the third domain is located less distant to the electroactive surface than the second domain; and sensor electronics operably connected to the electrode and configured to measure the signal from the electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification