System and method for prediction and detection of circulatory shock

• US 9,332,911 B2
• Filed: 08/13/2012
• Issued: 05/10/2016
• Est. Priority Date: 05/16/2007
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Parlikar, Tushar A., Heldt, Thomas, Verghese, George C., Mark, Roger Greenwood
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): TRAN, THO Q
• Application Number:
  US13/572,949
• Publication Number:
  US 20120306884A1
• Time in Patent Office: 1,366 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/33 specially adapted for cooperation with other devices
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

Systems and methods for prediction and detection of circulatory shock using estimates or measurements of arterial blood pressure, heart rate, stroke volume, cardiac output, total peripheral resistance, cardiac ejection fraction, cardiac contractility and ventricular end-diastolic volume are provided. These estimates and measurements are used to determine a type of circulatory shock. In some embodiments, the type of circulatory shock is determined to be one of septic shock, hypovolemic shock, anaphylactic shock, hemorrhagic shock, and cardiogenic shock.

Claims

1. A system for displaying information about circulatory shock, comprising:

a display;

a processor; and

a memory storing computer-executable instructions which, when executed by the processor, cause the processor to;

receive arterial blood pressure information from a blood pressure measuring device,

compute a time series of estimates, based on the received arterial blood pressure information, of each of total peripheral resistance, ejection fraction, and ventricular end-diastolic volume,

select a type of circulatory shock, from a plurality of types of circulatory shock, based on the computed time series of estimates,

cause the display of at least one of the time series of estimates, and

cause the display of the selected type of circulatory shock.

2. The system of claim 1, wherein the at least one of the time series of estimates and the selected type of circulatory shock are displayed simultaneously.

3. The system of claim 1, wherein the time series of estimates are updated as additional arterial blood pressure information is received.

4. The system of claim 3, wherein the time series of estimates are updated upon an onset time of a cardiac beat.

5. The system of claim 1, further comprising a user interface, and wherein the memory stores computer-executable instructions which, when executed by the processor, cause the processor to:

receive, from the user interface, a user selection of at least one of the time series of estimates, and

wherein causing the display of the at least one of the time series of estimates comprises causing the display of the selected at least one of the time series of estimates.

6. The system of claim 1, further comprising a user interface, and wherein the memory stores computer-executable instructions which, when executed by the processor, cause the processor to:

receive, from the user interface, a user selection of a scale of a display axis, and

wherein causing the display of the at least one of the time series of estimates comprises causing the display of the at least one of the time series of estimates according to the selected scale.

7. The system of claim 6, wherein the scale is a temporal scale.

8. The system of claim 1, wherein the memory stores computer-executable instructions which, when executed by the processor, cause the processor to:

compute an additional time series of estimates, based on the received arterial blood pressure information, of at least one of cardiac output and cardiac contractility, and

cause the display of the additional time series.

9. The system of claim 1, wherein the memory stores computer-executable instructions which, when executed by the processor, cause the processor to:

cause the display of one or more time series of drug infusion information.

10. The system of claim 9, wherein the one or more time series of drug infusion information and the at least one of the time series of estimates are displayed simultaneously.

11. A computer-implemented method for displaying information about circulatory shock, comprising:

receiving, with at least one processor in communication with a display, arterial blood pressure information from a blood pressure measuring device;

computing a time series of estimates, based on the received arterial blood pressure information, of each of total peripheral resistance, ejection fraction, and ventricular end-diastolic volume;

selecting, with the at least one processor, a type of circulatory shock, from a plurality of types of circulatory shock, based on the computed time series of estimates;

causing the display of at least one of the time series of estimates; and

causing the display of the selected type of circulatory shock.

12. The computer-implemented method of claim 11, wherein the at least one of the time series of estimates and the selected type of circulatory shock are displayed simultaneously.

13. The computer-implemented method of claim 11, wherein the time series of estimates are updated as additional arterial blood pressure information is received.

14. The computer-implemented method of claim 13, wherein the time series of estimates are updated upon an onset time of a cardiac beat.

15. The computer-implemented method of claim 11, further comprising:

receiving, from a user interface, a user selection of at least one of the time series of estimates; and

wherein causing the display of the at least one of the time series of estimates comprises causing the display of the selected at least one of the time series of estimates.

16. The computer-implemented method of claim 11, further comprising:

receiving, from a user interface, a user selection of a scale of a display axis; and

wherein causing the display of the at least one of the time series of estimates comprises causing the display of the at least one of the time series of estimates according to the selected scale.

17. The computer-implemented method of claim 16, wherein the scale is a temporal scale.

18. The computer-implemented method of claim 11, further comprising:

computing an additional time series of estimates, based on the received arterial blood pressure information, of at least one of cardiac output and cardiac contractility; and

causing the display of the additional time series.

19. The computer-implemented method of claim 11, further comprising:

causing the display of one or more time series of drug infusion information.

20. The computer-implemented method of claim 19, wherein the one or more time series of drug infusion information and the at least one of the time series of estimates are displayed simultaneously.