Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging

• US 9,332,942 B2
• Filed: 01/28/2008
• Issued: 05/10/2016
• Est. Priority Date: 01/28/2008
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Jaffer, Farouc A., Ntziachristos, Vasilis
• Primary Examiner(s): TURCHEN, ROCHELLE DEANNA
• Application Number:
  US12/020,765
• Publication Number:
  US 20090192358A1
• Time in Patent Office: 3,025 Days
• Field of Search: 600/407, 600/410, 600473-476, 600/478
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/6456 Spatial resolved fluorescence measurements; Imaging

Abstract

Apparatus and method can be provided for obtaining information regarding at least one portion of a biological structure. For example, using a first arrangement, it is possible to generate a first electro-magnetic radiation to be forwarded to the portion and receive, from the portion, a second fluorescent radiation associated with the first electro-magnetic radiation Further, using a second arrangement, it is possible to obtain information associated with the second fluorescent radiation, and generate at least one image of the portion as a function of the second fluorescent radiation. According to an exemplary embodiment of the present invention, the first arrangement can be inserted into at least one lumen, and the image of the portion may be associated with the at least one lumen.

Claims

1. An apparatus for obtaining information regarding at least one portion of a chosen biological target, comprising:

a catheter having proximal and distal ends and an axis and including a first channel and a second channel,

wherein the first and second channels together are configured to transmit at least first, second, and third radiations,

wherein said first channel includes a first optical waveguide and is configured to transmit through the distal ends towards the proximal end, the first radiation that includes one of a mechanical radiation and an optical radiation including fluorescent radiation, the first radiation generated within said biological target in response to absorption by said target of third radiation transmitted through catheter from the proximal end;

wherein said second channel includes a second optical waveguide and is configured to transmit, from said biological target through the distal end towards the proximal end, the second radiation representing anatomical characteristics of said target and containing optical-computed-tomography (OCT) information;

wherein each of the first and second channels is structured to deflect a radiation transmitted through such channel to cause said radiation to traverse a first portion of such channel along the axis and a second portion of such channel along a line that is transverse to the axis;

wherein said first optical waveguide dimensioned to channel only the first radiation and the second optical waveguide is dimensioned to channel only the second radiation;

wherein the catheter is configured to outcouple said first and second radiations from the first and second optical waveguides at respectively corresponding first and second locations,

wherein the first location is defined at an outer surface of the first optical waveguide away from an output facet of the first optical waveguide at a proximal end thereof, the second location defined at an output facet of the second optical waveguide at a proximal end thereof,

and

a detector operably connected with the proximal end to acquire radiation energy and to produce output data representing said target, said output data including a first data portion representing the first radiation and a second data portion representing the second radiation.

2. The apparatus according to claim 1,

wherein the first and second optical waveguides extend beyond a sheath of the catheter,

wherein the first optical waveguide is configured to emit said first radiation from an output surface of the first optical waveguide at a location prior to a proximal end of the first optical waveguide.

3. The apparatus according to claim 1, further comprising a programmable processor operably connected with said detector,

wherein said first radiation includes incoherent radiation, said second radiation includes coherent radiation,

wherein said processor is enabled by program code stored on a tangible non-transitory computer-readable medium to extract, from said output data, data components representing portions of said first radiation at different wavelengths, which portions are received from different depths of said target,

wherein the processor is further configured to

generate first images of said target based on a) said data components and b) optical maps, which optical maps establish correspondence between the different depths of the target and wavelengths, and

generate second images of said target based on the portion of the output data representing said second radiation,

wherein said first and second images are spatially co-registered.

4. The apparatus according to claim 1, wherein said first radiation includes ultrasound.

5. The apparatus according to claim 1, wherein, in operation, both the first and second radiations are caused by the third radiation transmitted to the target through the catheter.

6. The apparatus according to claim 1, wherein the catheter is dimensioned to be inserted into a lumen of the chosen biological structure.

7. The apparatus according to claim 1, wherein the second radiation is produced by said biological target in response to a fourth radiation transmitted through a channel of the first and second channels from the proximal end, the fourth radiation being different from the third radiation,

each of the first, second, third and fourth radiations traversing a first portion of one of the first and second channels along the axis and a second portion of the one of the first and second channels along a line that is transverse to the axis.

8. The apparatus according to claim 1, wherein said first optical waveguide is coaxial and concentric with respect to said second optical waveguide.

9. The apparatus according to claim 1, further comprising

a programmable processor operably connected to the detector and programmed to generate

at least one first image based on i) the first data portion and ii) the second data portion used as image prior for the first portion and

at least one second image based on the second data portion.

10. The apparatus according to claim 9, wherein said processor is programmed

to convert the second data portion to an optical map that represents a distribution of an attenuation parameter as a function of depth in said target,

from said distribution, to generate a function that represents a correction to the first data portion, said correction defining contribution of second radiation acquired by the detector from a first depth in said target on second radiation acquired by the detector from a second depth in said target;

to form a corrected first data portion by weighing said first data portion with the function.