Topical compositions comprising fermented extracts of traditional methods of making and using same

• US 9,333,231 B2
• Filed: 10/01/2013
• Issued: 05/10/2016
• Est. Priority Date: 03/11/2009
• Status: Active Grant

• Current Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Original Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Inventors: Lu, Ming, Cheng, Jing, Chen, Chia-wen, Schnittger, Steven Francis
• Primary Examiner(s): CLARK, AMY LYNN
• Application Number:
  US14/043,035
• Publication Number:
  US 20150093461A1
• Time in Patent Office: 952 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/85 Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
• CPC Class Codes: A61K 36/06 Fungi, e.g. yeasts
• CPC Class Codes: A61K 36/068 Cordyceps
• CPC Class Codes: A61K 36/074 Ganoderma
• CPC Class Codes: A61K 36/076 Poria
• CPC Class Codes: A61K 36/10 Bryophyta
• CPC Class Codes: A61K 36/16 Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/23 Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
• CPC Class Codes: A61K 36/235 Foeniculum (fennel)
• CPC Class Codes: A61K 36/236 Ligusticum (licorice-root)
• CPC Class Codes: A61K 36/258 Panax (ginseng)
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/41 Crassulaceae (Stonecrop family)
• CPC Class Codes: A61K 36/535 Perilla (beefsteak plant)
• CPC Class Codes: A61K 36/539 Scutellaria (skullcap)
• CPC Class Codes: A61K 36/65 Paeoniaceae (Peony family), e.g. Chinese peony
• CPC Class Codes: A61K 36/69 Polygalaceae (Milkwort family)
• CPC Class Codes: A61K 36/704 Polygonum, e.g. knotweed
• CPC Class Codes: A61K 36/725 Ziziphus, e.g. jujube
• CPC Class Codes: A61K 36/752 : Citrus, e.g. lime, orange or lemon
• CPC Class Codes: A61K 36/756 : Phellodendron, e.g. corktree
• CPC Class Codes: A61K 36/804 : Rehmannia
• CPC Class Codes: A61K 36/8998 : Hordeum (barley)
• CPC Class Codes: A61K 8/9728 : Fungi, e.g. yeasts
• CPC Class Codes: A61K 8/9789 : Magnoliopsida [dicotyledons]
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61P 17/10 : Anti-acne agents
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin

Abstract

The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts are characterized by reduced odor and/or color in comparison with unfermented TCM extracts and are therefore more suitable for use in cosmetic products.

Claims

1. A topical composition for treating periorbital skin of a subject in need thereof, said composition comprising an effective amount of a blend of fermented extracts of an effective amount of Ligusticum chuanxiong root, Paeonia lactiflora root, Rehmannia glutinosa root, and Zizyphus jujube fruit, wherein said blend of fermented extracts is obtained by:

(i) blending Ligusticum chuanxiong root, Paeonia lactiflora root, Rehmannia glutinosa root, and Zizyphus jujube fruit to provide a blend of plant parts;

(ii) fermenting the blend of plant parts with a microorganism, wherein the microorganism is yeast cells, and culturing nutrients;

or

(iii) fermenting the blend of plant parts with microorganisms, wherein said microorganisms are yeast cells, in an aqueous environment in substantial absence of additional nutrients in a low nutrient media to catabolically process the blend of plant parts;

(iv) monitoring the fermentation of (ii) or (iii) for signs of plateauing biological activity;

(v) briefly raising the temperature to rupture the yeast cells to release yeast cell contents, or disrupting the yeast cells by sonication; and

(vi) filtering to remove yeast cell debris and to recover the blend of fermented extracts, wherein the blend of fermented extracts has reduced odor and/or color, wherein the blend of fermented extracts is in the form of a fine powder, and wherein the topical composition further comprises a cosmetically or pharmaceutically acceptable carrier.