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Engineered polypeptide agents for targeted broad spectrum influenza neutralization

  • US 9,334,309 B2
  • Filed: 01/24/2014
  • Issued: 05/10/2016
  • Est. Priority Date: 01/27/2010
  • Status: Active Grant
First Claim
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1. A method comprising steps of:

  • providing a sample from a patient suspected of suffering from an influenza infection;

    contacting the sample with an infold agent that binds a hemagglutinin (HA) polypeptide, wherein the infold agent comprises an infold selected from the group consisting of Infold-1, Infold-2, Infold-3, Infold-4, Infold-5, Infold-6, Infold-7, Infold-8, Infold-9, Infold-10, Infold-11, Infold-12, Infold-13, Infold-14, Infold-15, Infold-16, Infold-17, Infold-18, Infold-19, Infold-20, Infold-21, Infold-22, Infold-23, Infold-24, Infold-25, Infold-26, Infold-27, Infold-28, Infold-29, Infold-30, Infold-31, Infold-32, Infold-33, Infold-34, Infold-35, Infold-36, Infold-37, Infold-38, Infold-39, and Infold-40; and

    detecting binding of the infold agent to components in the sample; and

    based on the detected binding, diagnosing the patient as suffering from an influenza infection.

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