Computer-assisted karyotyping
First Claim
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1. A method for computer-assisted karyotyping, comprising:
- inputting a digitized image of metaphase chromosomes into a processor comprising an image processing module and a classifier module, wherein the image processing module comprises;
a segmenting function adapted for segmenting the digitized image for extracting individual chromosome images, wherein the segmenting function comprises measuring a contour of a chromosome border to detect extremes corresponding to telomeres and centromeres;
a bend correcting function adapted to straighten images of chromosomes that are bent or curved, wherein the bend correction function comprises an algorithm adapted to conformally map an ideal chromosome to the individual chromosome image;
a feature selection function adapted for distinguishing between chromosome bands;
wherein the classifier module generates a classification of the image as normal or abnormal and generates an output therefrom.
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Abstract
A system and method for computer-assisted karyotyping includes a processor which receives a digitized image of metaphase chromosomes for processing in an image processing module and a classifier module. The image processing module may include a segmenting function for extracting individual chromosome images, a bend correcting function for straightening images of chromosomes that are bent or curved and a feature selection function for distinguishing between chromosome bands. The classifier module, which may be one or more trained kernel-based learning machines, receives the processed image and generates a classification of the image as normal or abnormal.
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Citations
25 Claims
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1. A method for computer-assisted karyotyping, comprising:
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inputting a digitized image of metaphase chromosomes into a processor comprising an image processing module and a classifier module, wherein the image processing module comprises; a segmenting function adapted for segmenting the digitized image for extracting individual chromosome images, wherein the segmenting function comprises measuring a contour of a chromosome border to detect extremes corresponding to telomeres and centromeres; a bend correcting function adapted to straighten images of chromosomes that are bent or curved, wherein the bend correction function comprises an algorithm adapted to conformally map an ideal chromosome to the individual chromosome image; a feature selection function adapted for distinguishing between chromosome bands; wherein the classifier module generates a classification of the image as normal or abnormal and generates an output therefrom. - View Dependent Claims (2, 3, 4, 5, 6, 7, 23)
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8. A system for computer-assisted karyotyping, comprising:
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a data storage device for receiving and storing digitized images of metaphase chromosomes; a processor in communication with the data storage device comprising an image processing module and a classifier module, wherein the image processing module comprises; a segmenting function adapted for segmenting the digitized image for extracting individual chromosome images, wherein the segmenting function comprises measuring a contour of a chromosome border to detect extremes corresponding to telomeres and centromeres; a bend correcting function adapted to straighten images of chromosomes that are bent or curved, wherein the bend correction function comprises an algorithm adapted to conformally map an ideal chromosome to the individual chromosome image; a feature selection function adapted for distinguishing between chromosome bands; an output device in communication with the processor for displaying an output comprising a classification of the image as normal or abnormal. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 19, 24)
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16. A non-transitory machine-readable medium comprising a plurality of instructions that, in response to being executed, result in a computing system executing an automated karyotyping process, comprising:
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receiving a digitized image of metaphase chromosomes into a processor comprising an image processing module and a classifier module, wherein the image processing module comprises; a segmenting function adapted for segmenting the digitized image for extracting individual chromosome images, wherein the segmenting function comprises measuring a contour of a chromosome border to detect extremes corresponding to telomeres and centromeres; a bend correcting function adapted to straighten images of chromosomes that are bent or curved, wherein the bend correction function comprises an algorithm adapted to conformally map an ideal chromosome to the individual chromosome image; a feature selection function adapted for distinguishing between chromosome bands; classifying the processed image from the image processing module to separate normal and abnormal; and outputting a report to a display device, the report comprising a classification of the image as normal or abnormal. - View Dependent Claims (17, 18, 20, 21, 22, 25)
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Specification