Integration of user inputs and correction of deformation vector field in deformable image registration workflow

• US 9,336,591 B2
• Filed: 08/16/2012
• Issued: 05/10/2016
• Est. Priority Date: 08/30/2011
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Mallya, Yogisha, Bzdusek, Karl Antonin
• Primary Examiner(s): Azarian, Seyed
• Application Number:
  US14/237,910
• Publication Number:
  US 20140201670A1
• Time in Patent Office: 1,363 Days
• Field of Search: 382/100, 382/103, 382106-107, 382128-134, 382/154, 382/162, 382/168, 382/173, 382/181, 382/199, 382/232, 382254-255, 382/274, 382/276, 382285-291, 382/305, 382/312, 382/256, 375/7.084, 378/4, 378/21, 378/16, 345/424
• US Class Current: 1/1
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: G06F 3/0481 based on specific properties of the displayed interaction object or a metaphor-based environment, e.g. interaction with desktop elements like windows or icons, or assisted by a cursor's changing behaviour or appearance
• CPC Class Codes: G06F 3/04845 for image manipulation, e.g. dragging, rotation, expansion or change of colour
• CPC Class Codes: G06T 2200/24 involving graphical user interfaces [GUIs]
• CPC Class Codes: G06T 2207/10081 Computed x-ray tomography [CT]
• CPC Class Codes: G06T 2207/10088 Magnetic resonance imaging [MRI]
• CPC Class Codes: G06T 2207/10104 Positron emission tomography [PET]
• CPC Class Codes: G06T 2207/10108 Single photon emission computed tomography [SPECT]
• CPC Class Codes: G06T 2207/20012 Locally adaptive
• CPC Class Codes: G06T 2207/20104 Interactive definition of region of interest [ROI]
• CPC Class Codes: G06T 2207/30096 Tumor; Lesion
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G06T 7/30 Determination of transform parameters for the alignment of images, i.e. image registration

Abstract

Adeformation vector field (DVF) (22)is computed that relatively spatially registers a first image (16)and a second image (14). A contour (26)delineating a structure in the first image is adapted using the DVF to generate an initial contour (52)for the structure in the second image. A final contour (56)is received for the structure in the second image. The DVF is corrected based on the initial and final contours for the structure in the second image to generate a corrected DVF (32). The correction may comprise computing an adjustment DVF (62)relating the initial and final contours and combining the DVF and the adjustment DVF to generate the corrected DVF. The final contour may be received by displaying the second image overlaid with the initial contour, and receiving user adjustments of the overlaid contour with the overlaid contour updated for each received user adjustment.

Claims

1. A method comprising:

computing a deformation vector field (DVF) relatively spatially registering first and second images;

adapting a contour delineating a structure in the first image using the DVF to generate an initial contour for the structure in the second image;

receiving a final contour for the structure in the second image; and

correcting the DVF based on the initial and final contours for the structure in the second image to generate a corrected DVF;

wherein the computing, adapting, and correcting are performed by an electronic processing device; and

wherein the correcting comprises;

computing an adjustment deformation vector field (adjustment DVF) relating the initial and final contours for the structure in the second image;

and combining the DVF and the adjustment DVF to generate the corrected DVF.

2. The method of claim 1, wherein the combining comprises one of:

adding the adjustment DVF to the DVF to generate the corrected DVF, and

subtracting the adjustment DVF from the DVF to generate the corrected DVF.

3. The method of claim 1, wherein the receiving comprises:

displaying the second image and an overlaid contour comprising the initial contour for the structure in the second image; and

receiving one or more user adjustments of the overlaid contour, the displaying of the overlaid contour being updated responsive to each received user adjustment;

wherein the final contour for the structure in the second image comprises the initial contour including the received one or more user adjustments.

4. The method of claim 1, wherein the first image is a planning image for generating a radiation therapy plan and the second image is a treatment image for updating the radiation therapy plan, and the method further comprises:

updating one or more parameters of the radiation therapy plan to account for change occurring between acquisition of the planning image and acquisition of the treatment image, the updating being based at least on the corrected DVF.

5. The method of claim 4, wherein the updating of one or more parameters of the radiation therapy plan includes updating at least one of:

(1) an attenuation map, (2) a dose warping, and (3) a dose accumulation.

6. The method of claim 4, further comprising:

performing a radiation therapy session using the one or more updated parameters.

7. A non-transitory storage medium storing instructions executable by an electronic processing device to perform a method as set forth in claim 1.

8. An electronic processing device configured to perform a method as set forth in claim 1.

9. A non-transitory storage medium storing instructions executable by an electronic processing device to perform a method comprising:

adjusting a contour of a second image;

updating a deformation vector field (DVF) mapping between the second image and a first image based on the adjustment of the contour to generate an updated DVF mapping between the second image and the first image; and

wherein the updating comprises;

computing an adjustment DVF representing the adjustment of the contour;

and

combining the DVF and the adjustment DVF to generate the updated DVF.

10. The non-transitory storage medium as set forth in claim 9, wherein the method further comprises:

prior to the adjusting, generating the contour of the second image by applying the DVF to a contour of the first image.

11. The non-transitory storage medium as set forth in claim 9, wherein the adjusting comprises:

displaying the second image and the contour of the second image overlaid on the displayed second image; and

receiving and displaying user adjustments of the displayed overlaid contour.

12. The non-transitory storage medium as set forth in claim 9, further comprising:

generating the deformation vector field (DVF) by relatively spatially registering the first and second images.

13. The non-transitory storage medium as set forth in claim 9, wherein the first image is a planning image for generating a radiation therapy plan and the second image is a treatment image for updating the radiation therapy plan, and the method further comprises:

updating one or more parameters of the radiation therapy plan to account for change occurring between acquisition of the planning image and acquisition of the treatment image, the updating being based at least on the adjusted DVF.

14. An apparatus comprising:

an electronic processing device configured to compute a deformation vector field (DVF) spatially mapping a first image and a second image; and

a user interface configured to display the second image and an overlaid contour comprising an initial contour generated by mapping a contour of the first image to the second image using the DVF, the user interface further configured to receive and display user adjustments of the overlaid contour wherein the overlaid contour adjusted by said user adjustments defines a final contour;

the electronic processing device further configured to correct the DVF based on the initial contour and the final contour to generate a corrected DVF;

wherein the electronic processing device is configured to correct the DVF by;

computing an adjustment DVF spatially mapping the initial contour and the final contour; and

combining the DVF and the adjustment DVF to generate the corrected DVF.

15. The apparatus of claim 14, wherein the first image is a planning image for generating a radiation therapy plan and the second image is a treatment image for updating the radiation therapy plan, and the electronic processing device is further configured to update one or more parameters of the radiation therapy plan based at least on the corrected DVF.

16. The apparatus of claim 15, wherein the updating of one or more parameters of the radiation therapy plan is further based on the treatment image.

17. The apparatus of claim 15, further comprising:

a radiation therapy delivery system configured to perform a radiation therapy session using the one or more updated parameters.