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Method for enhancing red blood cell quality and survival during storage

  • US 9,339,025 B2
  • Filed: 08/25/2011
  • Issued: 05/17/2016
  • Est. Priority Date: 08/25/2010
  • Status: Active Grant
First Claim
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1. A method for enhancing red blood cell quality and survival during storage comprising(a) depleting a red blood cell sample of leukocytes;

  • (b) depleting said leukocyte depleted red blood sample of platelets;

    (c) adding an additive solution having a pH ranging from 5.5 to 7.0;

    (d) depleting said leukoreduced and platelet reduced red blood cell sample of both oxygen and carbon dioxide prior to storage, wherein carbon dioxide is depleted to a level of 5 mmHg at 21-25°

    C.; and

    (e) transferring the leukocyte, platelet and oxygen- and carbon dioxide-depleted red blood cell sample to an oxygen- and carbon dioxide-impermeable environment for storage, wherein said red blood cell sample has an acidic pH,thereby enhancing red blood cell quality and survival during storage.

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