Diagnosing intestinal ischemia based on oxygen saturation measurements
First Claim
Patent Images
1. A system comprising:
- a catheter device comprising;
an outer sheath, anda sensor probe, disposed inside the outer sheath, comprising a first optical fiber and a second optical fiber wherein distal ends of the first and second optical fibers are coupled to a tip of the sensor probe, where an oximeter sensor is formed,the tip of the sensor probe comprises a planar surface in which a first source structure and first detector structure are planar with the planar surface, wherein the first source structure is coupled to a cross-sectional end of the first optical fiber and the first detector structure is coupled to a cross-sectional end of the second optical fiber,at the tip, the first source structure and first detector structure are arranged in a line and there is a fixed distance between the first source structure and the first detector structure,the sensor probe comprises a second source structure and a second detector structure, a first distance is between the first source structure and the first detector structure, a second distance is between the first source structure and the second detector structure, a third distance is between the second source structure and the first detector structure, a fourth distance is between the second source structure and the second detector structure,the first distance is not equal to the second, third, and fourth distances, the second distance is not equal to the third and fourth distances, and the third distance is not equal to the fourth distance,wherein a third optical fiber couples to the second source structure, and a fourth optical fiber couples to the second detector structure,the tip comprises only the first source structure, second source structure, first detector structure, and second detector structure, wherein there are no source or detector structures between the first source structure and the first detector structure, second source structure and the second detector structure, the first source structure and the second source structure, the first source structure and the second source structure, andthere are no source or detector structures between the outer sheath and the first source structure, the outer sheath and the second source structure, the outer sheath and the first detector structure, and the outer sheath and the second detector structure,at the tip, a filler material is between the first source structure and first detector structure, and between the first source structure and first detector structure and the sheath to hold the first and second two optical fibers at the fixed distance,the oximeter sensor is adapted to measure oxygen saturation of tissue having a thickness greater than 0, where the fixed distance between the first source structure and first detector structure is greater than 0, the second distance is greater than 0, the third distance is greater than 0, and the fourth distance is greater than 0, thereby allowing the oximeter sensor to measure oxygen saturation for the thickness of the tissue; and
a system unit comprising a display, processor, signal emitter circuit, signal detector circuit, and a receptacle, wherein the receptacle is coupled to proximal ends of the first and second optical fibers,wherein the signal emitter circuit is configured to send an emitted signal through the first optical fiber to the first source structure and the signal detector circuit is configured to receive a returned signal from the second optical fiber that is coupled to the first detector structure, andthe emitted signal is light having a wavelength between about 600 nanometers to about 900 nanometers.
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Abstract
Devices and systems have a sensor probe configured to measure tissue oxygen saturation in the intestine or mesentery. The devices and systems can determine the oxygenation state of the entire thickness of the intestine or mesentery. Thus, embodiments of the invention can be applied in diagnosing intestinal ischemia in a patient, as well as in monitoring tissue oxygen saturation of the intestine or mesentery during or after a surgical procedure.
55 Citations
26 Claims
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1. A system comprising:
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a catheter device comprising; an outer sheath, and a sensor probe, disposed inside the outer sheath, comprising a first optical fiber and a second optical fiber wherein distal ends of the first and second optical fibers are coupled to a tip of the sensor probe, where an oximeter sensor is formed, the tip of the sensor probe comprises a planar surface in which a first source structure and first detector structure are planar with the planar surface, wherein the first source structure is coupled to a cross-sectional end of the first optical fiber and the first detector structure is coupled to a cross-sectional end of the second optical fiber, at the tip, the first source structure and first detector structure are arranged in a line and there is a fixed distance between the first source structure and the first detector structure, the sensor probe comprises a second source structure and a second detector structure, a first distance is between the first source structure and the first detector structure, a second distance is between the first source structure and the second detector structure, a third distance is between the second source structure and the first detector structure, a fourth distance is between the second source structure and the second detector structure, the first distance is not equal to the second, third, and fourth distances, the second distance is not equal to the third and fourth distances, and the third distance is not equal to the fourth distance, wherein a third optical fiber couples to the second source structure, and a fourth optical fiber couples to the second detector structure, the tip comprises only the first source structure, second source structure, first detector structure, and second detector structure, wherein there are no source or detector structures between the first source structure and the first detector structure, second source structure and the second detector structure, the first source structure and the second source structure, the first source structure and the second source structure, and there are no source or detector structures between the outer sheath and the first source structure, the outer sheath and the second source structure, the outer sheath and the first detector structure, and the outer sheath and the second detector structure, at the tip, a filler material is between the first source structure and first detector structure, and between the first source structure and first detector structure and the sheath to hold the first and second two optical fibers at the fixed distance, the oximeter sensor is adapted to measure oxygen saturation of tissue having a thickness greater than 0, where the fixed distance between the first source structure and first detector structure is greater than 0, the second distance is greater than 0, the third distance is greater than 0, and the fourth distance is greater than 0, thereby allowing the oximeter sensor to measure oxygen saturation for the thickness of the tissue; and a system unit comprising a display, processor, signal emitter circuit, signal detector circuit, and a receptacle, wherein the receptacle is coupled to proximal ends of the first and second optical fibers, wherein the signal emitter circuit is configured to send an emitted signal through the first optical fiber to the first source structure and the signal detector circuit is configured to receive a returned signal from the second optical fiber that is coupled to the first detector structure, and the emitted signal is light having a wavelength between about 600 nanometers to about 900 nanometers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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9. A system comprising:
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a catheter device comprising; an outer sheath, and a sensor probe, disposed inside the outer sheath, comprising a first optical fiber and a second optical fiber wherein distal ends of the first and second optical fibers are coupled to a tip of the sensor probe, where an oximeter sensor is formed, the tip of the sensor probe comprises a planar surface in which a first source structure and first detector structure are planar with the planar surface, wherein the first source structure is coupled to a cross-sectional end of the first optical fiber and the first detector structure is coupled to a cross-sectional end of the second optical fiber, at the tip, the first source structure and first detector structure are arranged in a line and there is a fixed distance between the first source structure and the first detector structure, at the tip, a filler material is between the first source structure and first detector structure, and between the first source structure and first detector structure and the sheath to hold the first and second two optical fibers at the fixed distance, the oximeter sensor is adapted to measure oxygen saturation of tissue having a thickness greater than 0, where the fixed distance between the first source structure and first detector structure is greater than 0, thereby allowing the oximeter sensor to measure oxygen saturation for the thickness of the tissue; and a system unit comprising a display, processor, signal emitter circuit, signal detector circuit, and a receptacle, wherein the receptacle is coupled to proximal ends of the first and second optical fibers, wherein the signal emitter circuit is configured to send an emitted signal through the first optical fiber to the first source structure and the signal detector circuit is configured to receive a returned signal from the second optical fiber that is coupled to the first detector structure, the emitted signal is light having a wavelength between about 600 nanometers to about 900 nanometers, the sensor probe comprises a second source structure and a second detector structure, a first distance is between the first source structure and the first detector structure and is greater than 0, a second distance is between the first source structure and the second detector structure and is greater than 0, a third distance is between the second source structure and the first detector structure and is greater than 0, a fourth distance is between the second source structure and the second detector structure and is greater than 0, the first distance is equal to the third distance, and the second distance is equal to the fourth distance, a third optical fiber couples to the second source structure a fourth optical fiber couples to the second detector structure, there are no source or detector structures between the first source structure and the first detector structure, second source structure and the second detector structure, the first source structure and the second source structure, the first source structure and the second source structure.
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10. A system comprising:
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a catheter device comprising; an outer sheath, and a sensor probe, disposed inside the outer sheath, comprising a first optical fiber and a second optical fiber wherein distal ends of the first and second optical fibers are coupled to a tip of the sensor probe, where an oximeter sensor is formed, the tip of the sensor probe comprises a planar surface in which a first source structure and first detector structure are planar with the planar surface, wherein the first source structure is coupled to a cross-sectional end of the first optical fiber and the first detector structure is coupled to a cross-sectional end of the second optical fiber, at the tip, the first source structure and first detector structure are arranged in a line and there is a fixed distance between the first source structure and the first detector structure, at the tip, a filler material is between the first source structure and first detector structure, and between the first source structure and first detector structure and the sheath to hold the first and second two optical fibers at the fixed distance, the oximeter sensor is adapted to measure oxygen saturation of tissue having a thickness greater than 0, where the fixed distance between the first source structure and first detector structure is greater than 0, thereby allowing the oximeter sensor to measure oxygen saturation for the thickness of the tissue; and a system unit comprising a display, processor, signal emitter circuit, signal detector circuit, and a receptacle, wherein the receptacle is coupled to proximal ends of the first and second optical fibers, wherein the signal emitter circuit is configured to send an emitted signal through the first optical fiber to the first source structure and the signal detector circuit is configured to receive a returned signal from the second optical fiber that is coupled to the first detector structure, the emitted signal is light having a wavelength between about 600 nanometers to about 900 nanometers, the sensor probe comprises four sensor structures arranged in a line and there are fixed distances greater than 0 between each of the structures, and there are no intervening sensor structures between each of the four sensor structures.
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26. A system to measure oxygen saturation of an intestinal wall tissue comprising:
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a catheter device comprising a flexible shaft having a length sufficient to extend flexibly from an anus of a patient to at least a small intestine of the patient, the catheter device comprising; an outer sheath, and a sensor probe, disposed inside the outer sheath, comprising a first optical fiber and a second optical fiber wherein distal ends of the first and second optical fibers are coupled to a tip of the sensor probe where an oximeter sensor is formed, the tip of the sensor probe comprises a planar surface in which a first source structure and first detector structure are planar with the planar surface, wherein the first source structure is coupled to a cross-sectional end of the first optical fiber and the first detector structure is coupled to a cross-sectional end of the second optical fiber, at the tip, the first source structure and first detector structure are arranged in a line and there is a fixed distance between the first source structure and the first detector structure, the sensor probe comprises a second source structure and a second detector structure, a first distance is between the first source structure and the first detector structure, a second distance is between the first source structure and the second detector structure, a third distance is between the second source structure and the first detector structure, a fourth distance is between the second source structure and the second detector structure, the first distance is not equal to the second, third, and fourth distances, the second distance is not equal to the third and fourth distances, and the third distance is not equal to the fourth distance, wherein a third optical fiber couples the second source structure to a signal emitter circuit of the system unit, and a fourth optical fiber, coupling the second detector structure to a signal detector circuit of the system unit, the tip comprises only the first source structure, second source structure, first detector structure, and second detector structure, wherein there are no source or detector structures between the first source structure and the first detector structure, second source structure and the second detector structure, the first source structure and the second source structure, the first source structure and the second source structure, and there are no source or detector structures between the outer sheath and the first source structure, the outer sheath and the second source structure, the outer sheath and the first detector structure, and the outer sheath and the second detector structure, at the tip, a filler material is between the first source structure and first detector structure, and between the first source structure and first detector structure and the sheath to hold the first and second optical fibers at the fixed distance, the oximeter sensor is adapted to measure oxygen saturation of the intestinal wall tissue comprising a thickness of at least about 2 millimeters, where the fixed distance between the first source structure and first detector structure is from about 0.2 millimeters to about 3 millimeters, the second distance is greater than 0, the third distance is greater than 0, and the fourth distance is greater than 0, thereby allowing the oximeter sensor to measure oxygen saturation for the intestinal wall tissue; and a system unit comprising a display, processor, signal emitter circuit, signal detector circuit, and a receptacle, wherein the receptacle is coupled to proximal ends of the first and second optical fibers, wherein the signal emitter circuit is configured to send an emitted signal through the first optical fiber to the first source structure and the signal detector circuit is configured to receive a returned signal from the second optical fiber that is coupled to the first detector structure, and the emitted signal is light having a wavelength between about 600 nanometers to about 900 nanometers.
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Specification
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Current AssigneeViOptix, Inc.
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Original AssigneeViOptix, Inc.
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InventorsHeaton, Larry C. II, Lash, Robert E., Mao, Jimmy Jian-min
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Primary Examiner(s)Dougherty, Sean
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Assistant Examiner(s)CERIONI, DANIEL LEE
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Application NumberUS12/410,007Time in Patent Office2,611 DaysField of Search600/339US Class Current1/1CPC Class CodesA61B 1/00163 Optical arrangements A61B1/...A61B 1/018 for receiving instrumentsA61B 2090/3937 Visible markersA61B 5/14551 for measuring blood gasesA61B 5/14552 Details of sensors speciall...A61B 5/1459 invasive, e.g. introduced i...A61B 5/4255 Intestines, colon or appendixA61B 5/6852 CathetersA61B 5/742 using visual displays A61B5...A61B 90/39 Markers, e.g. radio-opaque ...
