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Device and method for determining analyte levels

  • US 9,339,223 B2
  • Filed: 12/30/2013
  • Issued: 05/17/2016
  • Est. Priority Date: 03/04/1997
  • Status: Expired due to Fees
First Claim
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1. A device for measuring a glucose concentration in a host, the device comprising:

  • an implantable sensor operably connected to an electronic circuit and configured to continuously measure a signal indicative of a glucose concentration in a host for a period of time; and

    a membrane located over at least a portion of the sensor, wherein the membrane is configured to control a flux of oxygen and glucose, wherein the membrane comprises a product of a reaction of a compound comprising an isocyanate group with a compound comprising a hydroxyl group and/or a compound comprising an amine group;

    wherein the device during in vitro testing is capable of exhibiting, at a glucose concentration of 400 mg/dL, no more than a 10% drop in sensor output in response to a change of dissolved oxygen concentration from a pO2 of 150 mm Hg to 30 mm Hg.

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