Device and method for determining analyte levels
First Claim
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1. A device for measuring a glucose concentration in a host, the device comprising:
- an implantable sensor operably connected to an electronic circuit and configured to continuously measure a signal indicative of a glucose concentration in a host for a period of time; and
a membrane located over at least a portion of the sensor, wherein the membrane is configured to control a flux of oxygen and glucose, wherein the membrane comprises a product of a reaction of a compound comprising an isocyanate group with a compound comprising a hydroxyl group and/or a compound comprising an amine group;
wherein the device during in vitro testing is capable of exhibiting, at a glucose concentration of 400 mg/dL, no more than a 10% drop in sensor output in response to a change of dissolved oxygen concentration from a pO2 of 150 mm Hg to 30 mm Hg.
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Abstract
Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
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Citations
5 Claims
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1. A device for measuring a glucose concentration in a host, the device comprising:
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an implantable sensor operably connected to an electronic circuit and configured to continuously measure a signal indicative of a glucose concentration in a host for a period of time; and a membrane located over at least a portion of the sensor, wherein the membrane is configured to control a flux of oxygen and glucose, wherein the membrane comprises a product of a reaction of a compound comprising an isocyanate group with a compound comprising a hydroxyl group and/or a compound comprising an amine group; wherein the device during in vitro testing is capable of exhibiting, at a glucose concentration of 400 mg/dL, no more than a 10% drop in sensor output in response to a change of dissolved oxygen concentration from a pO2 of 150 mm Hg to 30 mm Hg. - View Dependent Claims (2, 3, 4, 5)
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Specification