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Intradermal delivery of substances

  • US 9,339,613 B2
  • Filed: 03/13/2015
  • Issued: 05/17/2016
  • Est. Priority Date: 06/29/2000
  • Status: Expired due to Term
First Claim
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1. A method for administration of insulin to a human subject, comprising delivering the insulin through the lumen of a hollow needle into an intradermal compartment of the human subject'"'"'s skin, which method comprises:

  • (a) inserting the needle into the subject'"'"'s skin so that the needle penetrates the intradermal compartment, and the needle'"'"'s outlet depth and exposed height of the outlet are located within the intradermal compartment, wherein the outlet has an exposed height of about 0 to 1 mm; and

    (b) delivering the insulin through the lumen of the needle with the application of pressure in an amount effective to control the rate of delivery of the insulin,so that the insulin is delivered through the lumen of the needle into the intradermal compartment and the subject exhibits a decreased time to reach 50% of the maximum plasma concentration (T50) of insulin absorption as compared to subcutaneous delivery.

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