Glass compositions with improved chemical and mechanical durability

• US 9,340,447 B2
• Filed: 04/30/2015
• Issued: 05/17/2016
• Est. Priority Date: 10/25/2011
• Status: Active Grant

• Current Assignee: Corning Incorporated
• Original Assignee: Corning Incorporated
• Inventors: Danielson, Paul Stephen, DeMartino, Steven Edward, Drake, Melinda Ann, Morena, Robert Michael, Pal, Santona, Schaut, Robert Anthony
• Primary Examiner(s): Green, Anthony J
• Assistant Examiner(s): Bolden, Elizabeth A.
• Application Number:
  US14/701,185
• Publication Number:
  US 20150232374A1
• Time in Patent Office: 383 Days
• US Class Current: 1/1
• CPC Class Codes: A61J 1/00 Containers specially adapted for medical or pharmaceutical purposes capsules or the like for oral use A61J3/07; specially adapted for surgical or diagnostic appliances or instruments A61B50/30; containers for radioactive substances G21F5/00
• CPC Class Codes: C03C 21/002 to perform ion-exchange between alkali ions C03C21/005 takes precedence
• CPC Class Codes: C03C 2204/00 Glasses, glazes or enamels with special properties
• CPC Class Codes: C03C 3/087 containing calcium oxide, e.g. common sheet or container glass
• CPC Class Codes: C03C 3/091 containing aluminium
• CPC Class Codes: C03C 4/18 for ion-sensitive glass
• CPC Class Codes: C03C 4/20 for chemical resistant glass
• CPC Class Codes: Y10T 428/131 Glass, ceramic, or sintered, fused, fired, or calcined metal oxide or metal carbide containing [e.g., porcelain, brick, cement, etc.]
• CPC Class Codes: Y10T 428/1317 Multilayer [continuous layer]
• CPC Class Codes: Y10T 428/26 Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension
• CPC Class Codes: Y10T 428/315 Surface modified glass [e.g., tempered, strengthened, etc.]

Abstract

The embodiments described herein relate to chemically and mechanically durable glass compositions and pharmaceutical packaging formed from the same. According to one embodiment, a glass for pharmaceutical packaging includes from about 70 mol. % to about 80 mol. % SiO₂; from about 4 mol. % to about 8 mol. % alkaline earth oxide, the alkaline earth oxide comprising MgO and CaO; X mol. % Al₂O₃, wherein X is from about 4 to about 8; and Y mol. % alkali oxide comprising non-zero amounts of Na₂O and K₂O, wherein Y is about 9-15 mol. % and a ratio of Y:X is greater than 1.

Claims

1. A glass for pharmaceutical packaging having a glass composition comprising:

from about 70 mol. % to about 80 mol. % SiO₂;

from about 4 mol. % to about 8 mol. % alkaline earth oxide, the alkaline earth oxide comprising MgO and CaO;

X mol. % Al₂O₃, wherein X is from 4 to about 8; and

Y mol. % alkali oxide comprising non-zero amounts of Na₂O and K₂O, wherein a concentration of K₂O is from 0.01 to less than 2, Y is about 9-15 mol. % and a ratio of Y;

X is greater than 1.

2. The glass for pharmaceutical packaging of claim 1, wherein the SiO₂ is present in an amount from about 74 mol. % to about 78 mol. %.

3. The glass for pharmaceutical packaging of claim 1, wherein the alkaline earth oxide comprises a ratio (CaO (mol. %)/(CaO (mol. %)+MgO (mol. %))) is less than or equal to 0.5.

4. The glass for pharmaceutical packaging of claim 1, wherein the alkaline earth oxide comprises from about 0.1 mol. % to about 1.0 mol. % CaO.

5. The glass for pharmaceutical packaging of claim 1, wherein a ratio of Y:

X is less than or equal to 2.

6. The glass for pharmaceutical packaging of claim 5, wherein the alkali oxide comprises Na₂O in an amount greater than 8 mol. %.

7. The glass for pharmaceutical packaging of claim 1, wherein the glass composition is free of boron and compounds of boron.

8. The glass for pharmaceutical packaging of claim 1, wherein the glass has a type HGB1 hydrolytic resistance according to ISO 719.

9. The glass for pharmaceutical packaging of claim 1, wherein the glass has at least a class S3 acid resistance according to DIN 12116.

10. The glass for pharmaceutical packaging of claim 1, wherein the glass has at least a class A2 base resistance according to ISO 695.

11. The glass of claim 1, wherein a coefficient of thermal expansion of the glass is less than 70×

10<sup>−

7</sup>K<sup>−

1</sup>.

12. The glass for pharmaceutical packaging of claim 1, wherein the glass is ion exchange strengthened and has a compressive stress layer with a depth of layer greater than or equal to 10 μ

m and a surface compressive stress greater than or equal to 250 MPa.

13. The glass for pharmaceutical packaging of claim 12, wherein the glass has a type HGA1 hydrolytic resistance according to ISO 720 before and after ion exchange strengthening.

14. A glass for pharmaceutical packaging having a glass composition comprising:

from about 74 mol. % to about 80 mol. % SiO₂;

alkaline earth oxide comprising MgO and CaO and a ratio (CaO (mol. %)/(CaO (mol. %)+MgO (mol. %))) is greater than 0 and less than or equal to 0.5 and the CaO is from 0.1 to about 1.0 mol. %;

X mol. % Al₂O₃, wherein X is from about 4 to about 8; and

Y mol. % alkali oxide comprising non-zero amounts of Na₂O and K₂O, wherein Y is greater than about 8 mol. %, a ratio of Y;

X is greater than or equal to 1, and a ratio of a concentration of B₂O₃ (mol. %) to (Y mol. %-X mol. %) is less than or equal to 0.3.

15. The glass for pharmaceutical packaging of claim 14, wherein the alkaline earth oxide comprises from about 3 mol. % to about 7 mol. % MgO.

16. The glass for pharmaceutical packaging of claim 14, wherein a ratio of Y:

X is less than or equal to 2.

17. The glass for pharmaceutical packaging of claim 14, wherein the alkali oxide comprises Na₂O in an amount greater than 8 mol. %.

18. The glass for pharmaceutical packaging of claim 14, wherein the glass composition is free of boron and compounds of boron.

19. The glass for pharmaceutical packaging of claim 14, wherein the glass is ion exchange strengthened and has a compressive stress layer with a depth of layer greater than or equal to 10 μ

m and a surface compressive stress greater than or equal to 250 MPa.

20. The glass for pharmaceutical packaging of claim 14, wherein the glass has a type HGB1 hydrolytic resistance according to ISO 719.

21. The glass of claim 14, wherein a coefficient of thermal expansion of the glass is less than 70×

10<sup>−

7</sup>K<sup>−

1</sup>.

22. A glass for pharmaceutical packaging having a glass composition comprising:

from about 70 mol. % to about 80 mol. % SiO₂;

from about 4 mol. % to about 8 mol. % alkaline earth oxide comprising MgO and CaO and a ratio (CaO (mol. %)/(CaO (mol. %)+MgO (mol. %))) is greater than 0 and less than or equal to 0.5,

X mol. % Al₂O₃; and

Y mol. % alkali oxide comprising non-zero amounts of Na₂O and K₂O, wherein Y is about 9-14 mol. %, a ratio of Y;

X is greater than or equal to 1 and less than or equal to 2, and a ratio of a concentration of B₂O₃ (mol. %) to (Y mol. %-X mol. %) is less than or equal to 0.3.

23. The glass for pharmaceutical packaging of claim 22, wherein the alkaline earth oxide comprises from about 3 mol. % to about 7 mol. % MgO and from about 0.1 mol. % to about 1.0 mol. % CaO.

24. The glass for pharmaceutical packaging of claim 22, wherein the alkali oxide comprises Na₂O in an amount greater than 8 mol. %.

25. The glass of claim 22, wherein a coefficient of thermal expansion of the glass is less than 70×

10<sup>−

7</sup> K<sup>−

1</sup>.

26. A glass for pharmaceutical packaging having a glass composition comprising:

from about 70 mol. % to about 80 mol. % SiO₂;

alkaline earth oxide comprising MgO and CaO and a ratio (CaO (mol. %)/(CaO (mol. %)+MgO (mol. %))) is greater than 0 and less than or equal to 0.5;

X mol. % Al₂O₃, wherein X is from about 6 to about 8; and

Y mol. % alkali oxide comprising non-zero amounts of Na₂O and K₂O, wherein Y is from about 9 mol. % to about 15 mol. %.

27. The glass for pharmaceutical packaging of claim 26, wherein the alkali oxide comprises Na₂O in an amount greater than 8 mol. %.

28. The glass of claim 26, wherein a coefficient of thermal expansion of the glass is less than 70×

10<sup>−

7</sup>K<sup>−

1</sup>.