Method and optical system for evaluating concentrations of components in tissue
First Claim
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1. A method for evaluating concentrations of components in a tissue, comprising the following steps:
- (A) providing an optical system for evaluating concentrations of components in a tissue, comprising;
a multi-wavelength light source;
a detecting probe comprising at least one optical fiber set and a diffuser, wherein each optical fiber set respectively comprises at least two source optical fibers and at least one detector optical fiber, and source-to-detector distances in each optical fiber set are different, the source optical fibers connect with the multi-wavelength light source, the source optical fibers deliver light from the multi-wavelength light source onto a tested tissue via the diffuser, and the detector optical fiber penetrates the diffuser to receive the diffused light from the source optical fibers as reflected by the tested tissue;
an aligner disposed on the detecting probe for positioning a light emitting from the multi-wavelength light source on the tested tissue;
a detecting device coupled to the detector optical fiber to receive reflected light from the tested tissue to obtain diffuse reflectance spectra; and
an output device connected to the detecting device;
(B) illuminating a tested tissue with light from the multi-wavelength light source, in which the light passes into the tested tissue;
(C) detecting reflected light from the tested tissue with the detecting device coupled to the detector optical fiber to receive reflected light from the tested tissue to obtain diffuse reflectance spectra;
(D) converting the diffuse reflectance spectra into absorption spectra;
(E) fitting the absorption spectra with known chromophore absorption spectra to derive concentrations of components in the tested tissue by an equation (I) represented as follows;
μ
a(λ
)=CHbO2μ
aHbO2(λ
)+CHbμ
aHb(λ
)+CMelaninμ
aMelanin(λ
)+CWaterμ
aWater(λ
) +CFatμ
aFat(λ
)+CCollagenμ
aCollagen(λ
)
(I)wherein μ
a(λ
) is a total absorption coefficient, μ
aHbO2(λ
) is an absorption coefficient of oxygenated hemoglobin, μ
aHb(λ
) is an absorption coefficient of deoxygenated hemoglobin, μ
aMelanin(λ
)is a absorption coefficient of melanin, μ
aWater(λ
)is an absorption coefficient of water, μ
aFat(λ
) is an absorption coefficient of lipid, μ
aCollagen(λ
) is an absorption coefficient of collagen, CHbO2 is a concentration of oxygenated hemoglobin, CHb is a concentration of deoxygenated hemoglobin, CMelanin is a concentration of melanin, CWater is a concentration of water, CFat is a concentration of lipid, and Ccollagen is a concentration of collagen;
(F) obtaining a ratio of the concentration of one of the components measured at a first direction to that measured at a second direction by an equation (II) represented as follows;
R =(Cv/Cp)−
1
(II)wherein R is the ratio of the concentration of the component measured at the first direction to that measured at the second direction, Cv is the concentration of the component measured at the first direction, Cp is the concentration of the component measured at the second direction, and both Cv and Cp are one of CHbO2, CHb, CMelanin, CWater, CFat, and CCollagen; and
(G) outputting the ratio of the concentration of the component using the output device,wherein the ratio of the concentration for scar or keloid is higher than the ratio of the concentration for normal skin.
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Abstract
A method and an optical system for evaluating the spatial distribution of the concentrations of components in tissue are disclosed. The novel detecting probe included in the optical system comprises plural optical fiber sets, each optical fiber set respectively comprises at least one source optical fiber and at least one detector optical fiber, the source optical fiber connects with the multi-wavelength light source, the source optical fiber delivers light from the multi-wavelength light source onto a tested tissue; and the angle between one optical fiber set and another optical fiber set is greater than 0° and less than and not equal to 180°. Through the optical system of the present invention, the spatial distribution of the concentrations of components such as water, hemoglobin, melanin, lipid, and collagen in the tested tissue can be derived by an equation (I) defined in the present specification.
13 Citations
18 Claims
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1. A method for evaluating concentrations of components in a tissue, comprising the following steps:
-
(A) providing an optical system for evaluating concentrations of components in a tissue, comprising; a multi-wavelength light source; a detecting probe comprising at least one optical fiber set and a diffuser, wherein each optical fiber set respectively comprises at least two source optical fibers and at least one detector optical fiber, and source-to-detector distances in each optical fiber set are different, the source optical fibers connect with the multi-wavelength light source, the source optical fibers deliver light from the multi-wavelength light source onto a tested tissue via the diffuser, and the detector optical fiber penetrates the diffuser to receive the diffused light from the source optical fibers as reflected by the tested tissue; an aligner disposed on the detecting probe for positioning a light emitting from the multi-wavelength light source on the tested tissue; a detecting device coupled to the detector optical fiber to receive reflected light from the tested tissue to obtain diffuse reflectance spectra; and an output device connected to the detecting device; (B) illuminating a tested tissue with light from the multi-wavelength light source, in which the light passes into the tested tissue; (C) detecting reflected light from the tested tissue with the detecting device coupled to the detector optical fiber to receive reflected light from the tested tissue to obtain diffuse reflectance spectra; (D) converting the diffuse reflectance spectra into absorption spectra; (E) fitting the absorption spectra with known chromophore absorption spectra to derive concentrations of components in the tested tissue by an equation (I) represented as follows;
μ
a(λ
)=CHbO2μ
aHbO2(λ
)+CHbμ
aHb(λ
)+CMelaninμ
aMelanin(λ
)+CWaterμ
aWater(λ
) +CFatμ
aFat(λ
)+CCollagenμ
aCollagen(λ
)
(I)wherein μ
a(λ
) is a total absorption coefficient, μ
aHbO2(λ
) is an absorption coefficient of oxygenated hemoglobin, μ
aHb(λ
) is an absorption coefficient of deoxygenated hemoglobin, μ
aMelanin(λ
)is a absorption coefficient of melanin, μ
aWater(λ
)is an absorption coefficient of water, μ
aFat(λ
) is an absorption coefficient of lipid, μ
aCollagen(λ
) is an absorption coefficient of collagen, CHbO2 is a concentration of oxygenated hemoglobin, CHb is a concentration of deoxygenated hemoglobin, CMelanin is a concentration of melanin, CWater is a concentration of water, CFat is a concentration of lipid, and Ccollagen is a concentration of collagen;(F) obtaining a ratio of the concentration of one of the components measured at a first direction to that measured at a second direction by an equation (II) represented as follows;
R =(Cv/Cp)−
1
(II)wherein R is the ratio of the concentration of the component measured at the first direction to that measured at the second direction, Cv is the concentration of the component measured at the first direction, Cp is the concentration of the component measured at the second direction, and both Cv and Cp are one of CHbO2, CHb, CMelanin, CWater, CFat, and CCollagen; and (G) outputting the ratio of the concentration of the component using the output device, wherein the ratio of the concentration for scar or keloid is higher than the ratio of the concentration for normal skin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An optical system for evaluating concentrations of components in a tissue, comprising:
-
a multi-wavelength light source; a detecting probe comprising at least one optical fiber set and a diffuser, wherein each optical fiber set respectively comprises at least two source optical fibers and at least one detector optical fiber, source-to-detector distances in each optical fiber set are different, the source optical fibers connect with the multi-wavelength light source, the source optical fibers deliver light from the multi-wavelength light source onto a tested tissue via the diffuser, and the detector optical fiber penetrates the diffuser to receive the diffused light from the source optical fibers as reflected by the tested tissue; an aligner disposed on the detecting probe for positioning a light emitting from the multi-wavelength light source on the tested tissue; and a detecting device coupled to the detector optical fiber to receive reflected light from the tested tissue to obtain diffuse reflectance spectra. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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Specification
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Current AssigneeNational Cheng KUNG University (Government of The Republic of China)
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Original AssigneeNational Cheng KUNG University (Government of The Republic of China)
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InventorsTseng, Sheng-Hao, Hsu, Chao-Kai, Tzeng, Shih-Yu, Cheng, Nan-Yu
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Primary Examiner(s)Luong, Peter
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Application NumberUS13/944,697Publication NumberTime in Patent Office1,042 DaysField of Search600/407, 600473-476US Class Current1/1CPC Class CodesA61B 5/1455 using optical sensors, e.g....A61B 5/443 Evaluating skin constituent...
