Gradually self-expanding stent

• US 9,345,600 B2
• Filed: 06/12/2014
• Issued: 05/24/2016
• Est. Priority Date: 12/23/2008
• Status: Active Grant

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Inventors: Jantzen, Alexandra E., Irwin, Nathaniel A., Melsheimer, Jeffry S.
• Primary Examiner(s): Woznicki, Jacqueline
• Application Number:
  US14/302,872
• Publication Number:
  US 20140296956A1
• Time in Patent Office: 712 Days
• Field of Search: 623/1.38, 623/1.3, 623/1.31
• US Class Current: 1/1
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/823 Stents, different from stent-grafts, adapted to cover an aneurysm
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

A gradually self-expanding stent is provided with a first region of stent cells. A restraining material is attached to the first region and restrains the first region from expanding to the expanded configuration. Over time the restraining material releases the first region to allow the first region to expand to the expanded diameter. The first region is located longitudinally between two second regions. The second regions expand at a faster rate than the first region.

Claims

1. A self-expanding stent, comprising:

a stent structure comprising a plurality of stent cells having a compressed configuration and an expanded configuration, said stent structure being self-expanding from said compressed configuration to said expanded configuration;

a first region and two second regions of said stent structure, said first region being disposed longitudinally between said second regions, said first region comprising a first plurality of said stent cells and a second plurality of said stent cells dispersed circumferentially amongst said first plurality of said stent cells, each of said first plurality of said stent cell comprising at least a pair of circumferentially adjacent structural members connected to each other through a first bend;

a first restraining material attached to said first region of said stent structure and extending across an entirety of a first material area defined by the pair of circumferentially adjacent structural members and the first bend, said second plurality of said stent cells being unrestrained by the first restraining material, said first restraining material initially restraining said first region from expanding to said expanded configuration, and said first restraining material releasing said first region over time to allow said first region to expand to said expanded configuration; and

wherein said second regions of said stent structure expand at a faster rate than said first region.

2. The self-expanding stent according to claim 1, wherein said second regions are open and unrestrained by any restraining material, said second regions thereby being free to immediately expand to said expanded configuration.

3. The self-expanding stent according to claim 1, wherein said second regions are disposed at a most proximal end and a most distal end of said stent structure.

4. The self-expanding stent according to claim 1, further comprising two third regions, said first region and said second regions being disposed longitudinally between said third regions, and a second restraining material attached to said second regions of said stent structure, said second restraining material initially restraining said second regions from expanding to said expanded configuration, and said second restraining material releasing said second regions over time to allow said second regions to expand to said expanded configuration, wherein said second restraining material releases said second regions at a faster rate than said first restraining material releases said first region.

5. The self-expanding stent according to claim 4, wherein said third regions are open and unrestrained by any restraining material, said third regions thereby being free to immediately expand to said expanded configuration.

6. The self-expanding stent according to claim 5, wherein said third regions are disposed at a most proximal end and a most distal end of said stent structure.

7. The self-expanding stent according to claim 1, wherein each of said first plurality of said stent cells in said first region comprising a second bend in addition to the first bend, said respective first and second bends facing each other and being longitudinally spaced apart, a plurality of structural members including the pair of circumferentially adjacent structural members and connecting said first and second bends, wherein each structural member has a length, each of said first plurality of said stent cells being defined by said first and second bends and said lengths of said plurality of structural members, and said first restraining material is attached to said first plurality of said stent cells along the entire length of said structural members, said first restraining material extending across an entirety of a second material area defined by said first and second bends and said plurality of structural members of each of said stent cells in said first plurality of said stent cells, said first restraining material thereby extending longitudinally across each of said second material areas between said first and second bends and circumferentially across each of said second material areas between said plurality of structural members disposed adjacent each other.

8. The self-expanding stent according to claim 7, wherein the second plurality of said stent cells is dispersed amongst said first plurality of said stent cells in a circumferentially uniform manner, said second plurality of said stent cells being open and unrestrained by any restraining material, said second plurality of said stent cells thereby being free to immediately expand.

9. The self-expanding stent according to claim 8, wherein a proportion of said first plurality of said stent cells to said second plurality of said stent cells is substantially equal.

10. The self-expanding stent according to claim 1, wherein said first region is disposed at a longitudinally central portion of said stent structure.

11. The self-expanding stent according to claim 10, wherein said first region is between 40% to 80% of a total length of said stent structure.

12. The self-expanding stent according to claim 1, wherein said first restraining material is biodegradable.

13. The self-expanding stent according to claim 1, wherein said first region is disposed at a longitudinally central portion of said stent structure, said first restraining material is biodegradable, said second regions are open and unrestrained by any restraining material, said second regions thereby being free to immediately expand to said expanded configuration, and said second regions are disposed at a most proximal end and a most distal end of said stent structure.

14. The self-expanding stent according to claim 13, wherein each of said first plurality of said stent cells in said first region comprising a second bend in addition to the first bend, said respective first and second bends facing each other and being longitudinally spaced apart, a plurality of structural members including the pair of circumferentially adjacent structural members and interconnecting said first and second bends, wherein each structural member has a length, each of said first plurality of said stent cells being defined by said first and second bends and said lengths of said plurality of structural members, and said first restraining material is attached to said first plurality of said stent cells along the entire length of said structural members, said first restraining material extending across an entirety of a second material area defined by said first and second bends and said plurality of structural members of each of said stent cells in said first plurality of said stent cells, said first restraining material thereby extending longitudinally across each of said second material areas between said first and second bends and circumferentially across each of said second material areas between said plurality of structural members disposed adjacent each other.

15. The self-expanding stent according to claim 14, wherein said second plurality of said stent cells is dispersed amongst said first plurality of said stent cells in a circumferentially uniform manner, said second plurality of said stent cells being open and unrestrained by any restraining material, said second plurality of said stent cells thereby being free to immediately expand.

16. The self-expanding stent according to claim 15, wherein said first region is between 40% to 80% of a total length of said stent structure.

17. The self-expanding stent according to claim 1, further comprising two third regions, said first region and said second regions being disposed longitudinally between said third regions, and a second restraining material attached to said second regions of said stent structure, said second restraining material initially restraining said second regions from expanding to said expanded configuration, and said second restraining material releasing said second regions over time to allow said second regions to expand to said expanded configuration, wherein said second restraining material releases said second regions at a faster rate than said first restraining material releases said first region, said first restraining material is biodegradable, said first region is disposed at a longitudinally central portion of said stent structure, and said third regions are disposed at a most proximal end and a most distal end of said stent structure.

18. The self-expanding stent according to claim 17, wherein said third regions are open and unrestrained by any restraining material, said third regions thereby being free to immediately expand to said expanded configuration.

19. The self-expanding stent according to claim 18, wherein each of said first plurality of said stent cells in said first region comprising a second bend in addition to the first bend, said respective first and second bends facing each other and being longitudinally spaced apart, a plurality of structural members including the pair of circumferentially adjacent structural members and interconnecting said first and second bends, wherein each structural member has a length, each of said first plurality of said stent cells being defined by said first and second bends and said lengths of said plurality of structural members, and said first restraining material is attached to said first plurality of said stent cells along the entire length of said structural members, said first restraining material extending across an entirety of a second material area defined by said first and second bends and said plurality of structural members of each of said stent cells in said first plurality of said stent cells, said first restraining material thereby extending longitudinally across each of said second material areas between said first and second bends and circumferentially across each of said second material areas between said plurality of structural members disposed adjacent each other, said second plurality of said stent cells dispersed amongst said first plurality of said stent cells in a circumferentially uniform manner, said second plurality of said stent cells being open and unrestrained by any restraining material, said second plurality of said stent cells thereby being free to immediately expand, and said second regions of said stent structure comprises a third plurality of said stent cells, each of said third plurality of said stent cells in said second regions comprising a third bend and a fourth bends, said respective third and fourth bends facing each other and being longitudinally spaced apart, said plurality of structural members interconnecting said third and fourth bends, each of said third plurality of said stent cells being defined by said third and fourth bends and said lengths of said plurality of structural members, and said second restraining material is attached to said third plurality of said stent cells along the entire length of said structural members, said second restraining material extending across an entirety of a third material area defined by said third and fourth bends and said plurality of structural members of each of said stent cells in said third plurality of said stent cells, said second restraining material thereby extending longitudinally across each of said third material areas between said third and fourth bends and circumferentially across each of said third material areas between said plurality of structural members disposed adjacent each other, and said second regions of said stent structure further comprises a fourth plurality of said stent cells dispersed amongst said third plurality of said stent cells in a circumferentially uniform manner, said fourth plurality of said stent cells being open and unrestrained by any restraining material, said fourth plurality of said stent cells thereby being free to immediately expand.

20. The self-expanding stent according to claim 19, wherein a proportion of said first plurality of said stent cells to said second plurality of said stent cells is substantially equal, a proportion of said third plurality of said stent cells to said fourth plurality of said stent cells is substantially equal, and said first region is between 40% to 80% of a total length of said stent structure.

21. A self-expanding stent, comprising:

a stent structure having a circumference and comprising a plurality of stent cells having a compressed configuration and an expanded configuration, said stent structure being self-expanding from said compressed configuration to said expanded configuration;

a first region and two second regions of said stent structure, said first region being disposed longitudinally between said second regions;

a first restraining material attached to said first region of said stent structure and forming regions about the circumference, said regions being circumferentially discontinuous, said first restraining material initially restraining said first region from expanding to said expanded configuration, and said first restraining material releasing said first region over time to allow said first region to expand to said expanded configuration; and

wherein said second regions of said stent structure expand at a faster rate than said first region.