Reduction of flake-like aggregation in nanoparticulate active agent compositions
First Claim
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1. A method of reducing flake-like aggregates in an injectable nanoparticulate active agent composition, comprising:
- (a) preparing a dispersion of a nanoparticulate active agent and at least one surface stabilizer, wherein the dispersion comprises a nanoparticulate active agent having an effective average particle size of less than about 2000 nm, at least one surface stabilizer, and a liquid in which the active agent is poorly soluble; and
(b) adding a flake-like aggregation reducing agent to the dispersion of step (a), wherein the flake-like aggregation reducing agent is a buffer or a sugar, and wherein addition of a buffer results in a composition having a pH above about 7.0.
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Abstract
This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.
188 Citations
14 Claims
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1. A method of reducing flake-like aggregates in an injectable nanoparticulate active agent composition, comprising:
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(a) preparing a dispersion of a nanoparticulate active agent and at least one surface stabilizer, wherein the dispersion comprises a nanoparticulate active agent having an effective average particle size of less than about 2000 nm, at least one surface stabilizer, and a liquid in which the active agent is poorly soluble; and (b) adding a flake-like aggregation reducing agent to the dispersion of step (a), wherein the flake-like aggregation reducing agent is a buffer or a sugar, and wherein addition of a buffer results in a composition having a pH above about 7.0. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification