Closed-loop feedback-driven sympathetic neuromodulation for affect control
DCFirst Claim
1. A system for modulation of the sympathetic nervous system in the treatment of disease, comprising:
- A. a sensing-module, configured to sense an input related to affect;
B. a signal processor in communication with sensing module and which calculates a neural state;
C. a control module-in communication with signal processor and which is configured to generate-a signal which modulates the sympathetic nervous system;
D. an output module in communication with said control module; and
E. a modulator configured to interface with a portion of the sympathetic nervous system.
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Accused Products
Abstract
A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators, comprising intracranial (IC) and peripheral stimulating electrodes and other actuators, in accordance with treatment parameters. The neurological control system may directly or indirectly control a portion of the autonomic nervous system, including the sympathetic and parasympathetic nervous system. Such treatment parameters may be derived from a neural or physiological response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
44 Citations
66 Claims
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1. A system for modulation of the sympathetic nervous system in the treatment of disease, comprising:
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A. a sensing-module, configured to sense an input related to affect; B. a signal processor in communication with sensing module and which calculates a neural state; C. a control module-in communication with signal processor and which is configured to generate-a signal which modulates the sympathetic nervous system; D. an output module in communication with said control module; and E. a modulator configured to interface with a portion of the sympathetic nervous system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A system for direct or indirect neural modulation of components of the sympathetic nervous system in the treatment of depression, comprising:
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A. a signal processor in communication with at least one of a sensor, said signal processor configured to calculate at least one state related to at least one sign or symptom of depression; B. a control circuit in communication with said signal processor and which is configured to generate a signal which modulates affect; C. an output stage circuit in communication with said control circuit; and D. a neuromodulator array in communication with said output stage circuit and configured to be interfaced with a portion of the sympathetic nervous system. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34)
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35. A method for the treatment of depression comprising:
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A. Selecting a patient with an affective disorder for treatment; B. Sensing a signal representative of affect in said patient with an affective disorder; C. Processing said signal to form a processed signal; D. Determining therapy magnitude as a function of said processed signal; and E. Delivering said therapy, whereby a neural structure comprising a component of the sympathetic nervous system is modulated to treat said affective disorder. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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56. A system for neural modulation of the sympathetic nervous system, comprising:
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A. a sensor array, configured to sense activity of a component of the sympathetic nervous system; B. a signal conditioning circuit, in electronic communication with said sensor array; C. a signal processor in electronic communication with said signal conditioning circuit, whereby said signal processor performs disease state estimation and generates a neural state representative of affect; D. a control circuit in electronic communication with said signal processor and which is configured to generate a signal which modulates affect; E. an output stage circuit in electronic communication with said control circuit; and F. a stimulating electrode array, in electronic communication with said output stage circuit.
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57. A system for neural modulation of the sympathetic nervous system, comprising:
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A. a sensor array; B. a signal conditioning circuit, in electronic communication with said sensor array; C. a signal processor in electronic communication with said signal conditioning circuit, whereby said signal processor performs disease state estimation; D. a control circuit in electronic communication with said signal processor and which generates a signal which is a function of affective disease state and which modulates affect; E. an output stage circuit in electronic communication with said control circuit; and F. a stimulating electrode array, configured to interface with a component of the sympathetic nervous system, in electronic communication with said output stage circuit.
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58. A system for neural modulation of the sympathetic nervous system, comprising:
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A. a sensor array, configured to interface with a component of the sympathetic nervous system; B. a signal conditioning circuit, in electronic communication with said sensor array; C. a signal processor, configured to estimate the neural state of a component of the sympathetic nervous system, in electronic communication with said signal conditioning circuit; D. a control circuit in electronic communication with said signal processor and configured to generate a signal to modulate affect; E. an output stage circuit in electronic communication with said control circuit; and F. a stimulating electrode array, in electronic communication with said output stage circuit.
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59. A system for neural modulation of the sympathetic nervous system, comprising:
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A. a sensor array; B. a signal conditioning circuit, in electronic communication with said sensor array; C. a signal processor, configured to estimate the neural state of a component of the sympathetic nervous system, said neural state is representative of affect, in electronic communication with said signal conditioning circuit; D. a control circuit in electronic communication with said signal processor and configured to generate a signal to modulate affect; E. an output stage circuit in electronic communication with said control circuit; and F. a stimulating electrode array, configured to interface with a component of the sympathetic nervous system, in electronic communication with said output stage circuit.
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60. A method for neural modulation of the sympathetic nervous system, comprising:
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A. placing a sensor array in communication with a user with an affective disorder; B. sensing a signal from said sensor array and representative of activity of a portion of the sympathetic nervous system; C. Processing said signal to form a processed signal, said signal is representative of neural state; D. Determining therapy magnitude for treatment of affective disorder; and E. Delivering said therapy to said user with an affective disorder. - View Dependent Claims (61, 62)
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63. A method for neural modulation of the sympathetic nervous system, comprising:
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A. sensing a signal representative of affect from a user with an affective disorder; B. Processing said signal to form a processed signal, which is calculated as a function of the difference between desired affect and present affect; C. Determining therapy magnitude as a function of said processed signal and which modulates a component of the sympathetic nervous system; and D. Delivering said therapy to the user to treat the affective disorder. - View Dependent Claims (64)
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65. A method for neural modulation of the sympathetic nervous system, comprising:
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A. selecting a user who has been diagnosed with an affective disorder; B. sensing a signal representative of affect from said user; C. Processing said signal to form a processed signal; D. Determining therapy magnitude as a function of said processed signal to treat said affective disorder; and E. Delivering said therapy to a component of the sympathetic nervous system. - View Dependent Claims (66)
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Specification