Timing control for paired plasticity

• US 9,345,886 B2
• Filed: 09/26/2014
• Issued: 05/24/2016
• Est. Priority Date: 07/02/2008
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: MicroTransponder Inc., Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Kilgard, Michael P., Cauller, Larry, Engineer, Navzer, McIntyre Rodriguez, Christa, Rosellini, Will
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): FAIRCHILD, MALLIKA DIPAYAN
• Application Number:
  US14/497,907
• Publication Number:
  US 20150012054A1
• Time in Patent Office: 606 Days
• Field of Search: 607 1- 3, 607/45
• US Class Current: 1/1
• CPC Class Codes: A61F 11/00 Methods or devices for treatment of the ears or hearing sense implantable prostheses that substitute or replace internal ear parts, e.g. ear-drums, A61F2/18; methods or devices to cause a change in the state of auditory consciousness A61M21/00; electrotherapy applying electrical stimulation of the auditory system, or circuits therefor A61N1/36; radiotherapy using optical stimulation of the auditory system A61N5/06; electro-acoustic hearing aids H04R25/00; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand headwear, e.g. caps or helmets, with means for protecting the ears A42B1/0188, A42B3/16
• CPC Class Codes: A61M 2021/0016 by the smell sense
• CPC Class Codes: A61M 2021/0022 by the tactile sense, e.g. vibrations
• CPC Class Codes: A61M 2021/0027 by the hearing sense
• CPC Class Codes: A61M 2021/0044 by the sight sense
• CPC Class Codes: A61M 2021/0072 with application of electrical currents
• CPC Class Codes: A61M 2021/0077 with application of chemical or pharmacological stimulus
• CPC Class Codes: A61M 21/00 Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
• CPC Class Codes: A61M 21/02 for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: A61M 2205/3515 using magnetic means
• CPC Class Codes: A61M 2230/06 Heartbeat rate only
• CPC Class Codes: A61M 2230/08 Other bio-electrical signals
• CPC Class Codes: A61M 2230/10 Electroencephalographic signals
• CPC Class Codes: A61M 2230/205 partial oxygen pressure (P-O2)
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 2230/432 partial CO2 pressure (P-CO2)
• CPC Class Codes: A61M 2230/50 Temperature
• CPC Class Codes: A61M 2230/60 Muscle strain, i.e. measured on the user
• CPC Class Codes: A61M 2230/65 Impedance, e.g. conductivity, capacity
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters
• CPC Class Codes: A61N 1/36053 : adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36067 : Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 : Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36092 : Mental training
• CPC Class Codes: A61N 1/361 : Phantom sensations, e.g. tinnitus
• CPC Class Codes: A61N 1/36103 : Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
• CPC Class Codes: A61N 1/36139 : with automatic adjustment
• CPC Class Codes: A61N 1/36167 : Timing, e.g. stimulation onset
• CPC Class Codes: A61N 5/0618 : Psychological treatment
• CPC Class Codes: A61N 5/0622 : Optical stimulation for exciting neural tissue
• CPC Class Codes: G09B 19/00 : Teaching not covered by other main groups of this subclass teaching or practice apparatus for gun-aiming or gun-laying F41G3/26
• CPC Class Codes: G09B 19/003 : Repetitive work cycles; Sequence of movements
• CPC Class Codes: G09B 23/28 : for medicine
• CPC Class Codes: H04R 25/75 : Electric tinnitus maskers providing an auditory perception

Abstract

Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.

Claims

1. A system comprising:

a therapeutic training interface configured to provide tone based therapy to a patient;

a vagus nerve interface configured to provide electrical stimulation to a vagus nerve of the patient, wherein

the system is configured to determine the beginning of the tone based therapy,

the system is configured to control stimulation to the vagus nerve and control the providing of the tone based therapy so that the stimulation to the vagus nerve and the providing of the tone based therapy is synchronized and the stimulation occurs after the beginning of the tone based therapy, and

the system is configured to control the therapeutic training interface and the vagus nerve interface so that at least one audible tone is provided to the patient followed by a waiting period followed the providing of at least one audible tone to the patient and wherein the respective at least one vagus nerve stimulations are paired with the at least one audible tones and so that at no audible tones and no vagus nerve stimulations are provided during the waiting period.

2. The system of claim 1, wherein:

the system is configured to control the therapeutic training interface to apply a series of audible tones to the patient in synchrony with the stimulation to the vagus nerve.

3. The system of claim 1, wherein:

the system is configured to control the therapeutic training interface and the vagus nerve interface such that at least one audible tone is provided to the patient followed by a waiting period followed the providing of at least one audible tone to the patient and so that respective at least one vagus nerve stimulations are paired with the at least one audible tones.

4. The system of claim 1, wherein:

the system is configured to control the therapeutic training interface and the vagus nerve interface such that at least one audible tone is provided to the patient followed by a waiting period followed the providing of at least one audible tone to the patient and so that respective at least one vagus nerve stimulations are paired with the at least one audible tones and such that at least one of no audible tones and no vagus nerve stumulations are provided during the waiting period.

5. The system of claim 1, wherein:

the system is configured to control the therapeutic training interface and the vagus nerve interface so that stimulation of the vagus nerve and providing of the audible tone temporally overlap.

6. The system of claim 1, wherein:

the system is configured to control the therapeutic training interface and the vagus nerve interface such that stimulation of the vagus nerve and providing of the audible tone are paired, and so that the temporal length of the stimulation of the vagus nerve is different than the temporal length of the providing of the audible tone to which the stimulation of the vagus nerve is paired.

7. The system of claim 1, wherein:

the system is configured so that stimulation of the vagus nerve by the vagus nerve interface is an exponential stimulation pulse.

8. The system of claim 1, wherein:

the system is configured so that stimulation of the vagus nerve by the vagus nerve interface is a train of discrete constant current stimulation pulses having a fixed duration and spaced at fixed intervals.

9. The system of claim 1, wherein the system is configured to control stimulation to the vagus nerve such that stimulation overlaps with the provided tone based therapy.

10. A system comprising:

a timing control system configured to treat tinnitus therapy comprising;

a sound generator configured to generate a plurality of sounds;

a vagus nerve stimulator configured to electrically stimulate a vagus nerve of a patient, wherein

the timing control system is configured to synchronize stimulation of the vagus nerve with the generation of the plurality of sounds,

the system is configured to identify the respective beginnings of the respective generated sounds,

wherein the system configured to provide electrical stimulation of the vagus nerve that respectively begins after the respective beginnings of the respective generated sounds, and wherein

the system is configured to synchronize the sounds with the vagus nerve stimulation so that at least one sound is provided to the patient followed by a waiting period followed by the providing of at least one sound to the patient and wherein respective at least one vagus nerve stimulations are paired with the at least one sound and wherein no sound is provided during the waiting period.

11. The system of claim 10, wherein:

the sound generator is configured to generate sounds, wherein each sound consists of only one frequency.

12. The system of claim 10, wherein:

the system is configured to control the sound generator to generate sound randomly.

13. The system of claim 10, wherein:

the system is configured to control an intensity of the sound generated by the sound generator.

14. The system of claim 10, wherein:

the system is configured to control a duty cycle of a pulse train of the vagus nerve stimulator so that the vagus nerve stimulation is followed by a period of non-stimulation at least as long as the length of time of the vagus nerve stimulation precedent the period of non-stimulation.

15. The system of claim 10, wherein:

the vagus nerve stimulator includes an electrode and a pulse generator connected to the electrode.

16. The system of claim 10, wherein the timing control system is configured to provide stimulation of the vagus nerve that overlaps with the generation of sound.

17. The system of claim 10, wherein the system is configured to send a series of stimulation trigger signals to the vagus nerve stimulator so that an electrical pulse train is provided so that the vagus nerve is stimulated with the electrical pulse train at the same time as the generation of the plurality of sounds.

18. The system of claim 10, wherein the system is configured to cause the sound generator to generate the plurality of sounds randomly.

19. A system, comprising:

a therapeutic training interface configured to provide sound to a patient;

a vagus nerve interface configured to provide electrical stimulation to a vagus nerve of the patient, wherein

the system is configured to control the electrical stimulation to the vagus nerve and control the providing of the sound so that the stimulation to the vagus nerve and the providing of the sound is synchronized,

the system is configured to identify the beginning of the providing of sound to the patient,

the system configured to provide stimulation of the vagus nerve that begins after the beginning of the provided sound, and

the system is configured to synchronize the sounds with the vagus nerve stimulation so that a plurality of respective sounds are provided to the patient, and wherein the system is configured to provide a waiting period between the respective provided sounds defined by a period where no sound is provided, and wherein respective at least one vagus nerve stimulations are paired with the respective sounds.