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Systems and methods for particle focusing in microchannels

  • US 9,347,595 B2
  • Filed: 07/21/2014
  • Issued: 05/24/2016
  • Est. Priority Date: 04/16/2007
  • Status: Active Grant
First Claim
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1. A system for focusing particles having a diameter (a) suspended within a moving fluid having a kinematic viscosity (v) into one or more localized stream lines, the system comprising:

  • a substrate;

    at least one focusing channel provided on the substrate, wherein the at least one focusing channel comprises an inlet and an outlet and has a hydraulic diameter (Dh) configured such that a ratio of the particle diameter a to the hydraulic diameter Dh is greater than or equal to about 0.07 and less than or equal to about 0.5;

    anda pumping element controlled to flow the moving fluid through the at least one focusing channel in a laminar flow at a maximum channel velocity (Um) sufficient to maintain a channel Reynolds number (Rc) of the fluid flow greater than or equal to about 1 and less than or equal to about 250, wherein

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