Systems and methods for particle focusing in microchannels
First Claim
1. A system for focusing particles having a diameter (a) suspended within a moving fluid having a kinematic viscosity (v) into one or more localized stream lines, the system comprising:
- a substrate;
at least one focusing channel provided on the substrate, wherein the at least one focusing channel comprises an inlet and an outlet and has a hydraulic diameter (Dh) configured such that a ratio of the particle diameter a to the hydraulic diameter Dh is greater than or equal to about 0.07 and less than or equal to about 0.5;
anda pumping element controlled to flow the moving fluid through the at least one focusing channel in a laminar flow at a maximum channel velocity (Um) sufficient to maintain a channel Reynolds number (Rc) of the fluid flow greater than or equal to about 1 and less than or equal to about 250, wherein
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Abstract
Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.
85 Citations
21 Claims
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1. A system for focusing particles having a diameter (a) suspended within a moving fluid having a kinematic viscosity (v) into one or more localized stream lines, the system comprising:
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a substrate; at least one focusing channel provided on the substrate, wherein the at least one focusing channel comprises an inlet and an outlet and has a hydraulic diameter (Dh) configured such that a ratio of the particle diameter a to the hydraulic diameter Dh is greater than or equal to about 0.07 and less than or equal to about 0.5; and a pumping element controlled to flow the moving fluid through the at least one focusing channel in a laminar flow at a maximum channel velocity (Um) sufficient to maintain a channel Reynolds number (Rc) of the fluid flow greater than or equal to about 1 and less than or equal to about 250, wherein - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification